Proteintech

AP3B1 Polyclonal Antibody

FIGURE: 1 / 4

AP3B1 Antibody (13384-1-AP) in WB

Various lysates were subjected to SDS PAGE followed by western blot with (Product # 13384-1-AP) AP3B1 antibody at dilution of 1:800 incubated at room temperature for 1.5 hours.

AP3B1 Antibody in Immunoprecipitation (IP)

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Product Details

13384-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 13 publications 13 publications

Immunocytochemistry (ICC/IF)

Assay-dependent

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

AP3B1 Fusion Protein Ag4225 (763-1094 aa encoded by BC038444)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.3 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: KTSDSSNDE SSSIEDSSSD SESESEPESE SESRRVTKEK EKKTKQDRTP LTKDVSLLDL DDFNPVSTPV ALPTPALSPS LMADLEGLHL STSSSVISVS TPAFVPTKTH VLLHRMSGKG LAAHYFFPRQ PCIFGDKMVS IQITLNNTTD RKIENIHIGE KKLPIGMKMH VFNPIDSLEP EGSITVSMGI DFCDSTQTAS FQLCTKDDCF NVNIQPPVGE LLLPVAMSEK DFKKEQGVLT GMNETSAVII AAPQNFTPSV IFQKVVNVAN VGAVPSGQDN IHRFAAKTVH SGSLMLVTVE LKEGSTAQLI INTEKTVIGS VLLRELKPVL SQG (763-1094 aa encoded by B C038444)

Target Information

AP3B1 is a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. Structurally, AP3B1 is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in AP3B1 are associated with Hermansky-Pudlak syndrome type 2.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Milk-derived small extracellular vesicles: nanomaterials to promote bone formation.

Journal of nanobiotechnology

Dong M,Shi C,Yu X,Yang Q,Wu S,Liu R,Liu T,Wang L,Niu W

Thu Aug 11 00:00:00 UTC 2022

BioID reveals an ATG9A interaction with ATG13-ATG101 in the degradation of p62/SQSTM1-ubiquitin clusters.

EMBO reports

Kannangara AR,Poole DM,McEwan CM,Youngs JC,Weerasekara VK,Thornock AM,Lazaro MT,Balasooriya ER,Oh LM,Soderblom EJ,Lee JJ,Simmons DL,Andersen JL

Tue Oct 05 00:00:00 UTC 2021

Defective AP-3-dependent VAMP8 trafficking impairs Weibel-Palade body exocytosis in Hermansky-Pudlak Syndrome type 2 blood outgrowth endothelial cells.

Haematologica

Karampini E,Schillemans M,Hofman M,van Alphen F,de Boer M,Kuijpers TW,van den Biggelaar M,Voorberg J,Bierings R

Tue Oct 01 00:00:00 UTC 2019

Modeling of Fibrotic Lung Disease Using 3D Organoids Derived from Human Pluripotent Stem Cells.

Cell reports

Strikoudis A,Cieślak A,Loffredo L,Chen YW,Patel N,Saqi A,Lederer DJ,Snoeck HW

Tue Jun 18 00:00:00 UTC 2019

In Vitro Disease Modeling of Hermansky-Pudlak Syndrome Type 2 Using Human Induced Pluripotent Stem Cell-Derived Alveolar Organoids.

Stem cell reports

Korogi Y,Gotoh S,Ikeo S,Yamamoto Y,Sone N,Tamai K,Konishi S,Nagasaki T,Matsumoto H,Ito I,Chen-Yoshikawa TF,Date H,Hagiwara M,Asaka I,Hotta A,Mishima M,Hirai T

Tue Mar 05 00:00:00 UTC 2019

Adaptor protein-3 complex is required for Vangl2 trafficking and planar cell polarity of the inner ear.

Molecular biology of the cell

Tower-Gilchrist C,Zlatic SA,Yu D,Chang Q,Wu H,Lin X,Faundez V,Chen P

Thu Aug 15 00:00:00 UTC 2019

Cellular and molecular defects in a patient with Hermansky-Pudlak syndrome type 5.

PloS one

Stephen J,Yokoyama T,Tolman NJ,O'Brien KJ,Nicoli ER,Brooks BP,Huryn L,Titus SA,Adams DR,Chen D,Gahl WA,Gochuico BR,Malicdan MC

Thu Sep 07 00:00:00 UTC 2017

Cellular and molecular defects in a patient with Hermansky-Pudlak syndrome type 5.

PloS one

Stephen J,Yokoyama T,Tolman NJ,O'Brien KJ,Nicoli ER,Brooks BP,Huryn L,Titus SA,Adams DR,Chen D,Gahl WA,Gochuico BR,Malicdan MC

Thu Sep 07 00:00:00 UTC 2017

Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model.

Nature communications

Bagh MB,Peng S,Chandra G,Zhang Z,Singh SP,Pattabiraman N,Liu A,Mukherjee AB

Tue Mar 07 00:00:00 UTC 2017

Misrouting of v-ATPase subunit V0a1 dysregulates lysosomal acidification in a neurodegenerative lysosomal storage disease model.

Nature communications

Bagh MB,Peng S,Chandra G,Zhang Z,Singh SP,Pattabiraman N,Liu A,Mukherjee AB

Tue Mar 07 00:00:00 UTC 2017

Matrix proteins of Nipah and Hendra viruses interact with beta subunits of AP-3 complexes.

Journal of virology

Sun W,McCrory TS,Khaw WY,Petzing S,Myers T,Schmitt AP

Sat Nov 01 00:00:00 UTC 2014

Matrix proteins of Nipah and Hendra viruses interact with beta subunits of AP-3 complexes.

Journal of virology

Sun W,McCrory TS,Khaw WY,Petzing S,Myers T,Schmitt AP

Sat Nov 01 00:00:00 UTC 2014

Matrix proteins of Nipah and Hendra viruses interact with beta subunits of AP-3 complexes.

Journal of virology

Sun W,McCrory TS,Khaw WY,Petzing S,Myers T,Schmitt AP

Sat Nov 01 00:00:00 UTC 2014

Matrix proteins of Nipah and Hendra viruses interact with beta subunits of AP-3 complexes.

Journal of virology

Sun W,McCrory TS,Khaw WY,Petzing S,Myers T,Schmitt AP

Sat Nov 01 00:00:00 UTC 2014

Chemical-genetic disruption of clathrin function spares adaptor complex 3-dependent endosome vesicle biogenesis.

Molecular biology of the cell

Zlatic SA,Grossniklaus EJ,Ryder PV,Salazar G,Mattheyses AL,Peden AA,Faundez V

Thu Aug 01 00:00:00 UTC 2013

Chemical-genetic disruption of clathrin function spares adaptor complex 3-dependent endosome vesicle biogenesis.

Molecular biology of the cell

Zlatic SA,Grossniklaus EJ,Ryder PV,Salazar G,Mattheyses AL,Peden AA,Faundez V

Thu Aug 01 00:00:00 UTC 2013

The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIα.

Molecular biology of the cell

Ryder PV,Vistein R,Gokhale A,Seaman MN,Puthenveedu MA,Faundez V

Mon Jul 01 00:00:00 UTC 2013

The WASH complex, an endosomal Arp2/3 activator, interacts with the Hermansky-Pudlak syndrome complex BLOC-1 and its cargo phosphatidylinositol-4-kinase type IIα.

Molecular biology of the cell

Ryder PV,Vistein R,Gokhale A,Seaman MN,Puthenveedu MA,Faundez V

Mon Jul 01 00:00:00 UTC 2013

Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Gokhale A,Larimore J,Werner E,So L,Moreno-De-Luca A,Lese-Martin C,Lupashin VV,Smith Y,Faundez V

Wed Mar 14 00:00:00 UTC 2012

Quantitative proteomic and genetic analyses of the schizophrenia susceptibility factor dysbindin identify novel roles of the biogenesis of lysosome-related organelles complex 1.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Gokhale A,Larimore J,Werner E,So L,Moreno-De-Luca A,Lese-Martin C,Lupashin VV,Smith Y,Faundez V

Wed Mar 14 00:00:00 UTC 2012

BLOC-2, AP-3, and AP-1 proteins function in concert with Rab38 and Rab32 proteins to mediate protein trafficking to lysosome-related organelles.

The Journal of biological chemistry

Bultema JJ,Ambrosio AL,Burek CL,Di Pietro SM

Fri Jun 01 00:00:00 UTC 2012

BLOC-2, AP-3, and AP-1 proteins function in concert with Rab38 and Rab32 proteins to mediate protein trafficking to lysosome-related organelles.

The Journal of biological chemistry

Bultema JJ,Ambrosio AL,Burek CL,Di Pietro SM

Fri Jun 01 00:00:00 UTC 2012

BLOC-2, AP-3, and AP-1 proteins function in concert with Rab38 and Rab32 proteins to mediate protein trafficking to lysosome-related organelles.

The Journal of biological chemistry

Bultema JJ,Ambrosio AL,Burek CL,Di Pietro SM

Fri Jun 01 00:00:00 UTC 2012

BLOC-2, AP-3, and AP-1 proteins function in concert with Rab38 and Rab32 proteins to mediate protein trafficking to lysosome-related organelles.

The Journal of biological chemistry

Bultema JJ,Ambrosio AL,Burek CL,Di Pietro SM

Fri Jun 01 00:00:00 UTC 2012

Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells.

Molecular biology of the cell

Zlatic SA,Tornieri K,L'Hernault SW,Faundez V

Sun May 15 00:00:00 UTC 2011

Clathrin-dependent mechanisms modulate the subcellular distribution of class C Vps/HOPS tether subunits in polarized and nonpolarized cells.

Molecular biology of the cell

Zlatic SA,Tornieri K,L'Hernault SW,Faundez V

Sun May 15 00:00:00 UTC 2011

Bioinformatics

Protein Aliases: adapter-related protein complex 3 subunit beta-1; adaptor protein complex AP-3 beta-1 subunit; Adaptor protein complex AP-3 subunit beta-1; adaptor related protein complex 3, beta 1 subunit; Adaptor-related protein complex 3 subunit beta-1; adaptor-related protein complex 3, beta 1 subunit; adaptor-related protein complex AP-3, beta 1 subunit; AP-3 complex beta-3A subunit; AP-3 complex subunit beta-1; ap3; Beta-3A-adaptin; beta3A-adaptin; Clathrin assembly protein complex 3 beta-1 large chain; recombination induced mutation 2

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Gene Aliases: ADTB3; ADTB3A; AP-3; AP3B1; AU015684; beta3A; C78395; HPS; HPS2; PE; pearl; rim2

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UniProt ID: (Human) O00203, (Mouse) Q9Z1T1

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Entrez Gene ID: (Human) 8546, (Mouse) 11774, (Rat) 309969

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Function(s)

protein phosphatase binding GTP-dependent protein binding molecular_function

Process(es)

protein targeting to lysosome transport zinc II ion transport intracellular protein transport blood coagulation anterograde axonal transport protein transport vesicle-mediated transport antigen processing and presentation melanosome organization antigen processing and presentation, exogenous lipid antigen via MHC class Ib anterograde synaptic vesicle transport positive regulation of NK T cell differentiation biological_process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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AP3B1 Polyclonal Antibody

AP3B1 Antibody (13384-1-AP) in WB

Product Details

13384-1-AP

Western Blot (WB)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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