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Proteintech
APC1 Polyclonal Antibody
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Product Details
21748-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
APC1 Fusion Protein Ag13399 (1596-1944 aa encoded by BC104902)
Conjugate
Form
Liquid
Concentration
0.39 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: STDNRYHLQ ALRHLYVLAA EPRLLVPVDV DTNTPCYALL EVTYKGTQWY EQTKEELMAP TLLPELHLLK QIKVKGPRYW ELLIDLSKGT QHLKSILSKD GVLYVKLRAG QLSYKEDPMG WQSLLAQTVA NRNSEARAFK PETISAFTSD PALLSFAEYF CKPTVNMGQK QEILDLFSSV LYECVTQETP EMLPAYIAMD QAIRRLGRRE MSETSELWQI KLVLEFFSSR SHQERLQNHP KRGLFMNSEF LPVVKCTIDN TLDQWLQVGG DMCVHAYLSG QPLEESQLSM LACFLVYHSV PAPQHLPPIG LEGSTSFAEL LFKFKQLKMP VRALLRLAPL LLGNPQPMVM (1596-1944 aa encoded by BC104902)
Target Information
Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC1, also known as mitotic checkpoint regulator (MCPR), is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: anaphase-promoting complex 1 (meiotic checkpoint regulator); Anaphase-promoting complex subunit 1; APC1; Cyclosome subunit 1; meiotic check point regulator; Mitotic checkpoint regulator; Testis-specific gene 24 protein
Gene Aliases: 2610021O03Rik; AI047775; AI853536; ANAPC1; APC1; AW547281; MCPR; TSG24
UniProt ID: (Human) Q9H1A4, (Mouse) P53995
Entrez Gene ID: (Human) 64682, (Rat) 311412, (Mouse) 17222
protein K11-linked ubiquitination
cell cycle
mitotic nuclear division
cell division
anaphase-promoting complex-dependent catabolic process
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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