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Proteintech
APC4 Polyclonal Antibody
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Product Details
14129-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
APC4 Fusion Protein Ag5225 (1-343 aa encoded by BC059383)
Conjugate
Form
Liquid
Concentration
0.15 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MLRFPTCFP SFRVVGEKQL PQEIIFLVWS PKRDLIALAN TAGEVLLHRL ASFHRVWSFP PNENTGKEVT CLAWRPDGKL LAFALADTKK IVLCDVEKPE SLHSFSVEAP VSCMHWMEVT VESSVLTSFY NAEDESNLLL PKLPTLPKNY SNTSKIFSEE NSDEIIKLLG DVRLNILVLG GSSGFIELYA YGMFKIARVT GIAGTCLALC LSSDLKSLSV VTEVSTNGAS EVSYFQLETN LLYSFLPEVT RMARKFTHIS ALLQYINLSL TCMCEAWEEI LMQMDSRLTK FVQEKNTTTS VQDEFMHLLL WGKASAELQT LLMNQLTVKG LKKLGQSIES SYSS (1-343 aa encoded by BC059383)
Target Information
A large protein complex, termed the anaphase-promoting complex (APC), or the cyclosome, promotes metaphase-anaphase transition by ubiquitinating its specific substrates such as mitotic cyclins and anaphase inhibitor, which are subsequently degraded by the 26S proteasome. Biochemical studies have shown that the vertebrate APC contains eight subunits. The composition of the APC is highly conserved in organisms from yeast to humans. The exact function of this gene product is not known. Two transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Anaphase-promoting complex subunit 4; APC4; Cyclosome subunit 4
Gene Aliases: 2610306D21Rik; ANAPC4; APC4; D5Ertd249e
UniProt ID: (Human) Q9UJX5, (Mouse) Q91W96
Entrez Gene ID: (Human) 29945, (Rat) 305420, (Mouse) 52206
regulation of mitotic metaphase/anaphase transition
anaphase-promoting complex-dependent catabolic process
protein K11-linked ubiquitination
mitotic nuclear division
protein ubiquitination involved in ubiquitin-dependent protein catabolic process
proteasome-mediated ubiquitin-dependent protein catabolic process
cell division
negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
positive regulation of ubiquitin-protein ligase activity involved in regulation of mitotic cell cycle transition
regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
cell cycle
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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