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Proteintech
APH1A Polyclonal Antibody
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Product Details
11643-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
APH1A Fusion Protein Ag2238 (1-265 aa encoded by BC015568)
Conjugate
Form
Liquid
Concentration
0.3 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MGAAVFFGC TFVAFGPAFA LFLITVAGDP LRVIILVAGA FFWLVSLLLA SVVWFILVHV TDRSDARLQY GLLIFGAAVS VLLQEVFRFA YYKLLKKADE GLASLSEDGR SPISIRQMAY VSGLSFGIIS GVFSVINILA DALGPGVVGI HGDSPYYFLT SAFLTAAIIL LHTFWGVVFF DACERRRYWA LGLVVGSHLL TSGLTFLNPW YEASLLPIYA VTVSMGLWAF ITAGGSLRSI QRSLLCRRQE DSRVMVYSAL RIPPED (1-265 aa encoded by B C015568)
Target Information
APH1 is an essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). The gamma-secretase complex is minimally composed of a presenilin homodimer (PSEN1 or PSEN2), nicastrin (NCSTN), APH1 (APH1A or APH1B) and PEN2, although other components may exist. APH1 probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: anterior pharynx defective 1 homolog A; anterior pharynx defective 1a homolog; aph-1 homolog A, gamma secretase subunit; APH-1a; Aph-1alpha; APH1A gamma secretase subunit; Gamma-secretase subunit APH-1A; Presenilin-stabilization factor; RP4-790G17.3
Gene Aliases: 6530402N02Rik; APH-1; APH-1A; APH1A; CGI-78; PSF; RGD1311546; UNQ579/PRO1141
UniProt ID: (Human) Q96BI3, (Mouse) Q8BVF7
Entrez Gene ID: (Human) 51107, (Mouse) 226548, (Rat) 365872
metanephros development
proteolysis
membrane protein ectodomain proteolysis
Notch signaling pathway
Notch receptor processing
protein processing
membrane protein intracellular domain proteolysis
amyloid precursor protein catabolic process
positive regulation of catalytic activity
positive regulation of apoptotic process
ephrin receptor signaling pathway
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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