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Invitrogen
APLNRA Polyclonal Antibody
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APLNRA Antibody (PA5-72239) in WB
Western blot analysis of APLNRA in various lysates. Samples were incubated with APLNRA polyclonal antibody (Product # PA5-72239) using a dilution of 1:2,000 followed by Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at a dilution of 1:10,000. Lysates/proteins: 20 µg per lane. Lane 1: Zebrafish lysates; Lane 2: Zebrafish muscle lysates. Predicted band size: 41 kDa. Blocking/Dilution buffer: 5% NFDM/TBST.
Product Details
PA5-72239
Product Specifications
Species Reactivity
Zebrafish
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide between 343-377 amino acids from the human region of DANRE aplnra
Conjugate
Form
Liquid
Concentration
0.4 mg/mL
Purification
Protein A, Antigen affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2718093
Target Information
Receptor for apelin coupled to G proteins that inhibit adenylate cyclase activity and plays a role in various processes in adults such as regulation of blood pressure, heart contractility, and heart failure. Also plays a key role in early development such as gastrulation and heart morphogenesis by acting as a receptor for apela hormone, promoting endoderm and mesendoderm cell migration and regulating the migration of cells fated to become myocardial progenitors, respectively (PubMed:24316148, PubMed:24407481). Acts redundantly with agtrl1b in heart development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Angiotensin II receptor-like 1a; angiotensin receptor-like 1; Angiotensin receptor-like 1a; Apelin receptor A; G-protein coupled receptor APJ A
Gene Aliases: Agtr1; agtrl1; agtrl1a; aplnra; msr; zgc:152843
UniProt ID: (Zebrafish) Q7SZP9
Entrez Gene ID: (Zebrafish) 561935
angiogenesis
blood vessel development
vasculogenesis
gastrulation with mouth forming second
lymph vessel development
signal transduction
G-protein coupled receptor signaling pathway
multicellular organism development
gastrulation
heart development
cell migration
angioblast cell migration from lateral mesoderm to midline
endodermal cell differentiation
cell migration involved in gastrulation
negative regulation of cAMP-mediated signaling
positive regulation of angiogenesis
cardiac muscle tissue development
positive regulation of release of sequestered calcium ion into cytosol
epiboly involved in gastrulation with mouth forming second
coronary vasculature development
regulation of nodal signaling pathway
positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis
positive regulation of inhibitory G-protein coupled receptor phosphorylation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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