Proteintech

APLP1 Polyclonal Antibody

APLP1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

FIGURE: 1 / 4

APLP1 Antibody (12305-2-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human brain tissue slide using 12305-2-AP ( APLP1 Antibody) at dilution of 1:50 (under 40x lens).

APLP1 Antibody in Immunoprecipitation (IP)

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Product Details

12305-2-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

APLP1 Fusion Protein Ag2951 (55-341 aa encoded by BC012889)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: QVAGLCGRL TLHRDLRTGR WEPDPQRSRR CLRDPQRVLE YCRQMYPELQ IARVEQATQA IPMERWCGGS RSGSCAHPHH QVVPFRCLPG EFVSEALLVP EGCRFLHQER MDQCESSTRR HQEAQEACSS QGLILHGSGM LLPCGSDRFR GVEYVCCPPP GTPDPSGTAV GDPSTRSWPP GSRVEGAEDE EEEESFPQPV DDYFVEPPQA EEEEETVPPP SSHTLAVVGK VTPTPRPTDG VDIYFGMPGE ISEHEGFLRA KMDLEERRMR QINEVMREWA MADNQSKN (55-341 aa encoded by BC012889 )

Target Information

This gene encodes a member of the highly conserved amyloid precursor protein gene family. The encoded protein is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. This cleavage liberates an intracellular cytoplasmic fragment that may act as a transcriptional activator. The encoded protein may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Tau and other proteins found in Alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans.

Science translational medicine

Simoes S,Neufeld JL,Triana-Baltzer G,Moughadam S,Chen EI,Kothiya M,Qureshi YH,Patel V,Honig LS,Kolb H,Small SA

Wed Nov 25 00:00:00 UTC 2020

Label-Free LC-MS/MS Proteomic Analysis of Cerebrospinal Fluid Identifies Protein/Pathway Alterations and Candidate Biomarkers for Amyotrophic Lateral Sclerosis.

Journal of proteome research

Collins MA,An J,Hood BL,Conrads TP,Bowser RP

Fri Nov 06 00:00:00 UTC 2015

Label-Free LC-MS/MS Proteomic Analysis of Cerebrospinal Fluid Identifies Protein/Pathway Alterations and Candidate Biomarkers for Amyotrophic Lateral Sclerosis.

Journal of proteome research

Collins MA,An J,Hood BL,Conrads TP,Bowser RP

Fri Nov 06 00:00:00 UTC 2015

Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo.

Molecular & cellular proteomics : MCP

Dislich B,Wohlrab F,Bachhuber T,Müller SA,Kuhn PH,Hogl S,Meyer-Luehmann M,Lichtenthaler SF

Thu Oct 01 00:00:00 UTC 2015

Label-free Quantitative Proteomics of Mouse Cerebrospinal Fluid Detects β-Site APP Cleaving Enzyme (BACE1) Protease Substrates In Vivo.

Molecular & cellular proteomics : MCP

Dislich B,Wohlrab F,Bachhuber T,Müller SA,Kuhn PH,Hogl S,Meyer-Luehmann M,Lichtenthaler SF

Thu Oct 01 00:00:00 UTC 2015

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.

The EMBO journal

Kuhn PH,Koroniak K,Hogl S,Colombo A,Zeitschel U,Willem M,Volbracht C,Schepers U,Imhof A,Hoffmeister A,Haass C,Roßner S,Bräse S,Lichtenthaler SF

Fri Jun 22 00:00:00 UTC 2012

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons.

The EMBO journal

Kuhn PH,Koroniak K,Hogl S,Colombo A,Zeitschel U,Willem M,Volbracht C,Schepers U,Imhof A,Hoffmeister A,Haass C,Roßner S,Bräse S,Lichtenthaler SF

Fri Jun 22 00:00:00 UTC 2012

Bioinformatics

Protein Aliases: Amyloid beta (A4) precursor-like protein 1; Amyloid beta precursor like protein 1; amyloid precursor-like protein 1; Amyloid-like protein 1; APLP; APLP 1; APLP-1; APLPAPLP-1

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Gene Aliases: APLP; APLP1

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UniProt ID: (Human) P51693, (Mouse) Q03157

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Entrez Gene ID: (Human) 333, (Mouse) 11803

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Function(s)

protein binding heparin binding alpha-2A adrenergic receptor binding alpha-2B adrenergic receptor binding alpha-2C adrenergic receptor binding identical protein binding transition metal ion binding metal ion binding

Process(es)

endocytosis apoptotic process cell adhesion adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway nervous system development organ morphogenesis negative regulation of cAMP biosynthetic process cellular response to norepinephrine stimulus mRNA polyadenylation regulation of translation extracellular matrix organization forebrain development

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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APLP1 Polyclonal Antibody

APLP1 Antibody (12305-2-AP) in IHC (P)

Product Details

12305-2-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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