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APOBEC3C Polyclonal Antibody

APOBEC3C Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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APOBEC3C Antibody (10591-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human ovary tumor tissue slide using 10591-1-AP ( APOBEC3C Antibody) at dilution of 1:200 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

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Product Details

10591-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:100-1:400

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

APOBEC3C Fusion Protein Ag0886 (1-190 aa encoded by BC011739)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.17 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MNPQIRNPM KAMYPGTFYF QFKNLWEAND RDETWLCFTV EGIKRRSVVS WKTGVFRNQV DSETHCHAER CFLSWFCDDI LSPNTKYQVT WYTSWSPCPD CAGEVAEFLA RHSNVNLTIF TARLYYFQYP CYQEGLRSLS QEGVAVEIMD YEDFKYCWEN FVYNDNEPFK PWKGLKTNFR LLKRRLRESL Q (1-190 aa encoded by BC011739)

Target Information

APOBEC (apolipoprotein B mRNA editing enzyme, catalytic) proteins inhibit retroviruses by deaminating cytosine residues of viral RNA and DNA. The seven APOBEC3 genes or pseudogenes are found in a cluster thought to result from gene duplication on chromosome 22. Like APOBEC3G, APOBEC3F deaminates deoxycytosine to deoxyuracil in the minus strand of HIV-1 DNA, resulting in G to A hypermutation in the plus strand of DNA. Thus, APOBEC3G and APOBEC3F provide a mechanism for innate immunity to retroviruses, and are also likely contribute to sequence variation observed in many viruses. Viral infectivity factor (Vif) imparts APOBEC3G and APOBEC3F resistance to HIV through impaired translation of their mRNA and accelerated posttranslational degradation of the APOBEC3 proteins by the 26S proteasome. Interestingly, HIV-1 Vif cannot form a complex with APOBEC3G or APOBEC3F of mouse origin as it does with the human protein, and thus mouse APOBEC3G and APOBEC3F function as a potent inhibitors of wildtype HIV-1 replication, where human APOBEC3G and APOBEC3F are only able to inhibit Vif-deficient HIV-1 replication. This implies that induction of APOBEC3G and APOBEC3F activity or a method of blocking their interaction with Vif may provide a method for therapeutic intervention.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

FEBS open bio

Morita T,Hayashi K

Wed Feb 01 00:00:00 UTC 2023

Aberrant APOBEC3C expression induces characteristic genomic instability in pancreatic ductal adenocarcinoma.

Oncogenesis

Qian Y,Gong Y,Zou X,Liu Y,Chen Y,Wang R,Dai Z,Tasiheng Y,Lin X,Wang X,Luo G,Yu X,Cheng H,Liu C

Fri Jun 24 00:00:00 UTC 2022

Infection of Bronchial Epithelial Cells by the Human Adenoviruses A12, B3, and C2 Differently Regulates the Innate Antiviral Effector APOBEC3B.

Journal of virology

Lejeune N,Poulain F,Willemart K,Blockx Z,Mathieu S,Gillet NA

Thu Jun 10 00:00:00 UTC 2021

APOBEC3A catalyzes mutation and drives carcinogenesis in vivo.

The Journal of experimental medicine

Law EK,Levin-Klein R,Jarvis MC,Kim H,Argyris PP,Carpenter MA,Starrett GJ,Temiz NA,Larson LK,Durfee C,Burns MB,Vogel RI,Stavrou S,Aguilera AN,Wagner S,Largaespada DA,Starr TK,Ross SR,Harris RS

Mon Dec 07 00:00:00 UTC 2020

Enterovirus 71 antagonizes the inhibition of the host intrinsic antiviral factor A3G.

Nucleic acids research

Li Z,Ning S,Su X,Liu X,Wang H,Liu Y,Zheng W,Zheng B,Yu XF,Zhang W

Fri Nov 30 00:00:00 UTC 2018

Enterovirus 71 antagonizes the inhibition of the host intrinsic antiviral factor A3G.

Nucleic acids research

Li Z,Ning S,Su X,Liu X,Wang H,Liu Y,Zheng W,Zheng B,Yu XF,Zhang W

Fri Nov 30 00:00:00 UTC 2018

Natural APOBEC3C variants can elicit differential HIV-1 restriction activity.

Retrovirology

Anderson BD,Ikeda T,Moghadasi SA,Martin AS,Brown WL,Harris RS

Mon Dec 17 00:00:00 UTC 2018

Natural APOBEC3C variants can elicit differential HIV-1 restriction activity.

Retrovirology

Anderson BD,Ikeda T,Moghadasi SA,Martin AS,Brown WL,Harris RS

Mon Dec 17 00:00:00 UTC 2018

Expression and subcellular localisation of AID and APOBEC3 in adenoid and palatine tonsils.

Scientific reports

Seishima N,Kondo S,Wakae K,Wakisaka N,Kobayashi E,Kano M,Moriyama-Kita M,Nakanishi Y,Endo K,Imoto T,Ishikawa K,Sugimoto H,Hatano M,Ueno T,Koura M,Kitamura K,Muramatsu M,Yoshizaki T

Wed Jan 17 00:00:00 UTC 2018

Expression and subcellular localisation of AID and APOBEC3 in adenoid and palatine tonsils.

Scientific reports

Seishima N,Kondo S,Wakae K,Wakisaka N,Kobayashi E,Kano M,Moriyama-Kita M,Nakanishi Y,Endo K,Imoto T,Ishikawa K,Sugimoto H,Hatano M,Ueno T,Koura M,Kitamura K,Muramatsu M,Yoshizaki T

Wed Jan 17 00:00:00 UTC 2018

Bioinformatics

Protein Aliases: A3C; APOBEC1-like; apolipoprotein B editing enzyme catalytic polypeptide-like 3C; apolipoprotein B mRNA editing enzyme catalytic polypeptide like 3C; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C; DNA dC->dU-editing enzyme APOBEC-3C; MGC19485; Phorbolin I; probable DNA dC->dU-editing enzyme APOBEC-3C

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Gene Aliases: A3C; APOBEC1L; APOBEC3C; ARDC2; ARDC4; ARP5; bK150C2.3; PBI

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UniProt ID: (Human) Q9NRW3

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Entrez Gene ID: (Human) 27350

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Function(s)

protein binding zinc ion binding hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines poly(A) RNA binding

Process(es)

cytidine deamination negative regulation of transposition negative regulation of viral genome replication innate immune response defense response to virus DNA demethylation

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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APOBEC3C Polyclonal Antibody

APOBEC3C Antibody (10591-1-AP) in IHC (P)

Product Details

10591-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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