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Bioss
AQP2 Polyclonal Antibody
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Product Details
BS-0261R
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
KLH conjugated synthetic peptide derived from human AQP2, amino acids 101-200.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
0.01M TBS, pH 7.4, with 50% glycerol, 1% BSA
Contains
0.02% ProClin 300
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Aquaporin 2 (AQP2) is a hormonally regulated water channel located in the renal collecting duct. Mutations in the AQP2 gene cause hereditary nephrogenic diabetes insipidus in humans. A vasopressin induced cAMP increase results in the phosphorylation of AQP2 at serine-256 and its translocation from the intracellular vesicles to the apical membrane of principal cells. Recently, serine-261 has been identified as a novel phosphorylation site on AQP2 and levels of phosphorylated S261 have been shown to decrease with vasopressin treatment suggesting its involvement in vasopressin-dependent AQP2 trafficking.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADH water channel; AQP 2; AQP CD; AQP-2; AQP-CD; AQPCD; aquaporin 2 (collecting duct); Aquaporin CD; Aquaporin-2; Aquaporin-CD; Aquaporin2; Aquaporine 2; Collecting duct water channel protein; MGC34501; Water channel protein for renal collecting duct; water-channel aquaporin 2; WCH CD; WCH-CD; WCHCD
Gene Aliases: AQP-2; AQP-CD; AQP2; aquaporin-2; cph; jpk; WCH-CD
UniProt ID: (Human) P41181, (Mouse) P56402, (Rat) P34080
Entrez Gene ID: (Human) 359, (Mouse) 11827, (Rat) 25386
renal water homeostasis
renal water transport
water transport
excretion
cellular water homeostasis
glycerol transport
ion transmembrane transport
cellular response to water deprivation
cellular response to copper ion
cellular response to mercury ion
metanephric collecting duct development
transport
cell volume homeostasis
apoptotic process
actin filament depolymerization
carbohydrate transmembrane transport
positive regulation of calcium ion transport
transmembrane transport
hyperosmotic response
female pregnancy
aging
response to water deprivation
response to salt stress
response to hormone
response to lithium ion
water homeostasis
response to lipopolysaccharide
response to glucagon
response to starvation
response to calcium ion
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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