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Osenses
AQP4 Polyclonal Antibody
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AQP4 Antibody (OSA00155W-100UL) in IHC (P)
IHC-P on paraffin sections of mouse epididymis. The animal was perfused using Autoperfuser at a pressure of 130 mmHg with 300 mL 4% FA being processed for paraffin embedding. HIER: Tris-EDTA, pH 9 for 20 min using Thermo PT Module. Blocking: 0.2% LFDM in TBST filtered thru 0.2 µm. Detection was done using Novolink HRP polymer from Leica following manufacturers instructions; DAB chromogen: Candela DAB chromo... View More
Product Details
OSA00155W-100UL
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ Ig
Class
Polyclonal
Type
Antibody
Immunogen
A synthetic peptide from mouse AQP4 conjugated to blue carrier protein was used as the antigen
Conjugate
Form
Lyophilized
Concentration
Conc. Not Determined
Storage buffer
whole serum
Contains
no preservative
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.
The peptide is homologous in rat.
Specificity of this antibody: AQP4.
Target Information
In skeletal muscle, AQP4 (aquaporin 4 also known as mercurial insensitive water channel), localizes to the sarcolemma of fast-twitch muscle fibers. Aquaporins (AQPs) are a large family of integral membrane water transport channel proteins that facilitate the transport of water through the cell membrane. This function is conserved in animals, plants and bacteria. Many isoforms of aquaporin have been identified in mammals, designated AQP0 through AQP10. Aquaporins are widely distributed and it is not uncommon for more than one type of AQP to be present in the same cell. Although most aquaporins are only permeable to water, AQP3, AQP7, AQP9 and one of the two AQP10 transcripts are also permeable to urea and glycerol.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: AQP-4; Aquaporin-4; Aquaporin4; HMIWC2; Mercurial-insensitive water channel; MGC22454; MIWC; WCH4
Gene Aliases: AQP-4; Aqp4; Miwc; MIWC2; WCH4
UniProt ID: (Mouse) P55088, (Rat) P47863
Entrez Gene ID: (Mouse) 11829, (Rat) 25293
transport
water transport
sensory perception of sound
cellular water homeostasis
regulation of vascular endothelial growth factor production
carbon dioxide transport
glycerol transport
water homeostasis
negative regulation of interleukin-1 beta production
negative regulation of interleukin-6 production
carbohydrate transmembrane transport
ion transmembrane transport
protein homooligomerization
transmembrane transport
negative regulation of cell adhesion molecule production
renal water absorption
cellular response to glucose stimulus
cellular response to interferon-gamma
female pregnancy
response to radiation
hyperosmotic salinity response
multicellular organismal water homeostasis
response to glucocorticoid
cellular response to interleukin-1
cellular response to interleukin-6
cellular response to estradiol stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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