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Proteintech
ARAP2 Polyclonal Antibody
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Product Details
25143-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ARAP2 Fusion Protein Ag18469 (1356-1704 aa encoded by BC105089)
Conjugate
Form
Liquid
Concentration
0.43 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LTNDILAIK NIIPTKGDIW ATFEVIENEE LERPLHYKEN VLEQVLRWSS LAEPGSAYLV VKRFLTADTI KHCSDRSTLG SIKEGILKIK EEPSKILSGN KFQDRYFVLR DGFLFLYKDV KSSKHDKMFS LSSMKFYRGV KKKMKPPTSW GLTAYSEKHH WHLCCDSSQT QTEWMTSIFI AQHEYDIWPP AGKERKRSIT KNPKIGGLPL IPIQHEGNAT LARKNIESAR AELERLRLSE KCDKESVDSS LKERASMVAH CLEHKDDKLR NRPRKHRSFN CLEDTEPEAP LGQPKGHKGL KTLRKTEDRN SKATLDSDHK LPSRVIEELN VVLQRSRTLP KELQDEQILK (1356-1704 aa encoded by BC105089)
Target Information
ARAP2 also known as Centaurin-delta-1 is a protein with ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. A phosphatidylinositol-3, 4, 5-trisphosphate-dependent GTPase-activating protein, ARAP2, binds to RhoA-GTP, but lacks the predicted catalytic arginine in the RHO-GAP domain and does not have RHO-GAP activity. It modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Usually ARAP2 is activated by phosphatidylinositol-3, 4, 5-trisphosphate (PtdIns(3, 4, 5)P3) binding and can be activated by phosphatidylinositol-3, 4-bisphosphate (PtdIns(3, 4, 5)P2) binding, albeit with lower efficiency. ARAP2 associates with focal adhesions and functions downstream of RhoA to regulate focal adhesion dynamics. It is usually detected in brain, thymus, lymph node, thyroid, spinal cord, trachea, heart, skeletal muscle, spleen, kidney, liver, placenta, lung and peripheral blood leukocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Arf and Rho GAP adapter protein 2; Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 2; centaurin; centaurin, delta 1; Centaurin-delta-1; Cnt-d1; PARX protein; Protein PARX
Gene Aliases: ARAP2; CENTD1; Gm148; KIAA0580; mKIAA0580; PARX
UniProt ID: (Human) Q8WZ64
Entrez Gene ID: (Human) 116984, (Mouse) 212285, (Rat) 305367
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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