Proteintech

ARC/ARG3.1 Polyclonal Antibody

ARC/ARG3.1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ARC/ARG3.1 Antibody (16290-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse brain tissue slide using (Product # 16290-1-AP) (ARC/ARG3.1 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

ARC/ARG3.1 Antibody in Western Blot (WB)

ARC/ARG3.1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

16290-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 16 publications 16 publications

Immunohistochemistry (IHC)

View 7 publications 7 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 5 publications 5 publications

Immunoprecipitation (IP)

0.5-4.0 µg

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ARC/ARG3.1 Fusion Protein Ag9445 (1-396 aa encoded by BC012321)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.27 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MELDHRTSG GLHAYPGPRG GQVAKPNVIL QIGKCRAEML EHVRRTHRHL LAEVSKQVER ELKGLHRSVG KLESNLDGYV PTSDSQRWKK SIKACLCRCQ ETIANLERWV KREMHVWREV FYRLERWADR LESTGGKYPV GSESARHTVS VGVGGPESYC HEADGYDYTV SPYAITPPPA AGELPGQEPA EAQQYQPWVP GEDGQPSPGV DTQIFEDPRE FLSHLEEYLR QVGGSEEYWL SQIQNHMNGP AKKWWEFKQG SVKNWVEFKK EFLQYSEGTL SREAIQRELD LPQKQGEPLD QFLWRKRDLY QTLYVDADEE EIIQYVVGTL QPKLKRFLRH PLPKTLEQLI QRGMEVQDDL EQAAEPAGPH LPVEDEAETL TPAPNSESVA SDRTQPE (1-396 aa encoded by BC012321)

Target Information

Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory. Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1. In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

ARC/Arg3.1 expression in the lateral geniculate body of monocular form deprivation amblyopic kittens.

BMC ophthalmology

Fan H,Wang Y,Zou Y,Song W,Xie J,Tang X,Chen S

Tue Jan 03 00:00:00 UTC 2023

Long-Term Environmental Enrichment Relieves Dysfunctional Cognition and Synaptic Protein Levels Induced by Prenatal Inflammation in Older CD-1 Mice.

Neural plasticity

Zhang ZZ,Zeng LP,Chen J,Wu YF,Wang YT,Xia L,Yang QG,Wang F,Chen GH

Thu May 19 00:00:00 UTC 2022

Effects of Fibroblast Growth Factor 21 on Lactate Uptake and Usage in Mice with Diabetes-Associated Cognitive Decline.

Molecular neurobiology

Zhao L,Jiang H,Xie J,Shen D,Yi Q,Yan J,Li C,Zheng H,Gao H

Thu Sep 01 00:00:00 UTC 2022

Hippocampal Iron Accumulation Impairs Synapses and Memory via Suppressing Furin Expression and Downregulating BDNF Maturation.

Molecular neurobiology

Zhang Y,Bai X,Zhang Y,Yao S,Cui Y,You LH,Yu P,Chang YZ,Gao G

Thu Sep 01 00:00:00 UTC 2022

Prions induce an early Arc response and a subsequent reduction in mGluR5 in the hippocampus.

Neurobiology of disease

Ojeda-Juárez D,Lawrence JA,Soldau K,Pizzo DP,Wheeler E,Aguilar-Calvo P,Khuu H,Chen J,Malik A,Funk G,Nam P,Sanchez H,Geschwind MD,Wu C,Yeo GW,Chen X,Patrick GN,Sigurdson CJ

Sat Oct 01 00:00:00 UTC 2022

Induction of A Disintegrin and Metalloproteinase with Thrombospondin motifs 1 by a rare variant or cognitive activities reduces hippocampal amyloid-β and consequent Alzheimer's disease risk.

Frontiers in aging neuroscience

Qiu Y,Sha L,Zhang X,Li G,Zhu W,Xu Q

Sat Aug 27 00:00:00 UTC 2022

Comprehensive profiling of novel epithelial-mesenchymal transition mediators and their clinical significance in colorectal cancer.

Scientific reports

Ishikawa S,Nishida N,Fujino S,Ogino T,Takahashi H,Miyoshi N,Uemura M,Satoh T,Yamamoto H,Mizushima T,Doki Y,Eguchi H

Thu Jun 03 00:00:00 UTC 2021

Comprehensive profiling of novel epithelial-mesenchymal transition mediators and their clinical significance in colorectal cancer.

Scientific reports

Ishikawa S,Nishida N,Fujino S,Ogino T,Takahashi H,Miyoshi N,Uemura M,Satoh T,Yamamoto H,Mizushima T,Doki Y,Eguchi H

Thu Jun 03 00:00:00 UTC 2021

Comprehensive profiling of novel epithelial-mesenchymal transition mediators and their clinical significance in colorectal cancer.

Scientific reports

Ishikawa S,Nishida N,Fujino S,Ogino T,Takahashi H,Miyoshi N,Uemura M,Satoh T,Yamamoto H,Mizushima T,Doki Y,Eguchi H

Thu Jun 03 00:00:00 UTC 2021

EGB761 ameliorates chronic cerebral hypoperfusion-induced cognitive dysfunction and synaptic plasticity impairment.

Aging

Yao ZH,Wang J,Yuan JP,Xiao K,Zhang SF,Xie YC,Mei JH

Wed Feb 03 00:00:00 UTC 2021

EGB761 ameliorates chronic cerebral hypoperfusion-induced cognitive dysfunction and synaptic plasticity impairment.

Aging

Yao ZH,Wang J,Yuan JP,Xiao K,Zhang SF,Xie YC,Mei JH

Wed Feb 03 00:00:00 UTC 2021

Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory.

Neuron

Li X,Zhang J,Li D,He C,He K,Xue T,Wan L,Zhang C,Liu Q

Wed Mar 17 00:00:00 UTC 2021

PQBP1 promotes translational elongation and regulates hippocampal mGluR-LTD by suppressing eEF2 phosphorylation.

Molecular cell

Shen Y,Zhang ZC,Cheng S,Liu A,Zuo J,Xia S,Liu X,Liu W,Jia Z,Xie W,Han J

Thu Apr 01 00:00:00 UTC 2021

Repressor element-1 silencing transcription factor regulates glutamate receptors and immediate early genes to affect synaptic plasticity.

Aging

Xu C,Zhang M,Zu L,Zhang P,Sun L,Liu X,Fang M

Wed Jun 09 00:00:00 UTC 2021

Dynamic Changes of Cytoskeleton-Related Proteins Within Reward-Related Brain Regions in Morphine-Associated Memory.

Frontiers in neuroscience

Yang X,Wen Y,Zhang Y,Gao F,Yang J,Yang Z,Yan C

Tue Feb 16 00:00:00 UTC 2021

Experience-Dependent Development and Maintenance of Binocular Neurons in the Mouse Visual Cortex.

Cell reports

Jenks KR,Shepherd JD

Tue Feb 11 00:00:00 UTC 2020

Effects of Prenatal Exposure to Inflammation Coupled With Stress Exposure During Adolescence on Cognition and Synaptic Protein Levels in Aged CD-1 Mice.

Frontiers in aging neuroscience

Zhang ZZ,Zhuang ZQ,Sun SY,Ge HH,Wu YF,Cao L,Xia L,Yang QG,Wang F,Chen GH

Mon Sep 28 00:00:00 UTC 2020

Effects of Prenatal Exposure to Inflammation Coupled With Stress Exposure During Adolescence on Cognition and Synaptic Protein Levels in Aged CD-1 Mice.

Frontiers in aging neuroscience

Zhang ZZ,Zhuang ZQ,Sun SY,Ge HH,Wu YF,Cao L,Xia L,Yang QG,Wang F,Chen GH

Mon Sep 28 00:00:00 UTC 2020

Herpes Simplex Virus Type 1 Enhances Expression of the Synaptic Protein Arc for Its Own Benefit.

Frontiers in cellular neuroscience