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The protein encoded by this gene belongs to the ARL (ADP-ribosylation factor-like) family of proteins, which are structurally related to ADP-ribosylation factors (ARFs). ARFs, described as activators of cholera toxin (CT) ADP-ribosyltransferase activity, regulate intracellular vesicular membrane trafficking, and stimulate a phospholipase D (PLD) isoform. Although, ARL proteins were initially thought not to activate CT or PLD, later work showed that they are weak stimulators of PLD and CT in a phospholipid dependent manner.
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Protein Aliases: ADP-ribosylation factor like GTPase 1; ADP-ribosylation factor-like 1; ADP-ribosylation factor-like protein 1; ADP-ribosylation-like 1
Gene Aliases: 2310008D22Rik; Arf7; ARFL1; ARL1; AU019749
UniProt ID: (Human) P40616, (Rat) P61212, (Mouse) P61211
Entrez Gene ID: (Human) 400, (Rat) 64187, (Mouse) 104303
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