Proteintech

ARG1 Monoclonal Antibody (5D6D12)

ARG1 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ARG1 Antibody (66129-1-IG) in IHC (P)

Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using 66129-1-IG ( ARG1 Antibody) at dilution of 1:500 (under 40x lens). heat mediated antigen retrieved with Tris-EDTA buffer (pH 9).

ARG1 Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

66129-1-IG

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:8,000

View 26 publications 26 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:200-1:1,000

Immunocytochemistry (ICC/IF)

View 17 publications 17 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Pig, Rat

Published species

Human, Mouse

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

5D6D12

Immunogen

ARG1 Fusion Protein Ag8810 (1-236 aa encoded by BC005321)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSAKSRTIG IIGAPFSKGQ PRGGVEEGPT VLRKAGLLEK LKEQECDVKD YGDLPFADIP NDSPFQIVKN PRSVGKASEQ LAGKVAEVKK NGRISLVLGG DHSLAIGSIS GHARVHPDLG VIWVDAHTDI NTPLTTTSGN LHGQPVSFLL KELKGKIPDV PGFSWVTPCI SAKDIVYIGL RDVDPGEHYI LKTLGIKYFS MTEVTRTVNT AVAITLACFG LAREGNHKPI DYLNPPK (1-236 aa encoded by BC005321)

Target Information

Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle. The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation. By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production. In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells. In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported. In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a). Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas. Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Lacticaseibacillus casei CNRZ1874 supplementation promotes M1 alveolar macrophage activation and attenuates Mycoplasma pneumoniae pneumonia.

Journal of applied microbiology

Zhang N,Zeng W,Du T,Wei H,Tian W,Meng Y,He G,Lei A,Zhu C

Wed Mar 01 00:00:00 UTC 2023

Gd-EOB MRI for HCC subtype differentiation in a western population according to the 5^th edition of the World Health Organization classification.

European radiology

Auer TA,Halskov S,Fehrenbach U,Nevermann NF,Pelzer U,Mohr R,Hamm B,Schöning W,Horst D,Ihlow J,Geisel D

Sun Oct 01 00:00:00 UTC 2023

Menstrual blood-derived endometrial stem cells alleviate neuroinflammation by modulating M1/M2 polarization in cell and rat Parkinson's disease models.

Stem cell research & therapy

Li H,Wei J,Zhang Z,Li J,Ma Y,Zhang P,Lin J

Thu Apr 13 00:00:00 UTC 2023

FNDC5/Irisin Inhibits the Inflammatory Response and Mediates the Aerobic Exercise-Induced Improvement of Liver Injury after Myocardial Infarction.

International journal of molecular sciences

Wang T,Yu M,Li H,Qin S,Ren W,Ma Y,Bo W,Xi Y,Cai M,Tian Z

Sun Feb 19 00:00:00 UTC 2023

CCL6 promotes M2 polarization and inhibits macrophage autophagy by activating PI3-kinase/Akt signalling pathway during skin wound healing.

Experimental dermatology

Feng X,Ji Y,Zhang C,Jin T,Li J,Guo J

Sat Apr 01 00:00:00 UTC 2023

CCL6 promotes M2 polarization and inhibits macrophage autophagy by activating PI3-kinase/Akt signalling pathway during skin wound healing.

Experimental dermatology

Feng X,Ji Y,Zhang C,Jin T,Li J,Guo J

Sat Apr 01 00:00:00 UTC 2023

Salidroside ameliorated the pulmonary inflammation induced by cigarette smoke via mitigating M1 macrophage polarization by JNK/c-Jun.

Phytotherapy research : PTR

Feng H,Zhang D,Yin Y,Kang J,Zheng R

Fri Sep 01 00:00:00 UTC 2023

Garlic-derived exosomes carrying miR-396e shapes macrophage metabolic reprograming to mitigate the inflammatory response in obese adipose tissue.

The Journal of nutritional biochemistry

Bian Y,Li W,Jiang X,Yin F,Yin L,Zhang Y,Guo H,Liu J

Wed Mar 01 00:00:00 UTC 2023

Garlic-derived exosomes carrying miR-396e shapes macrophage metabolic reprograming to mitigate the inflammatory response in obese adipose tissue.

The Journal of nutritional biochemistry

Bian Y,Li W,Jiang X,Yin F,Yin L,Zhang Y,Guo H,Liu J

Wed Mar 01 00:00:00 UTC 2023

BMP7 Attenuates Neuroinflammation after Spinal Cord Injury by Suppressing the Microglia Activation and Inducing Microglial Polarization Via the STAT3 Pathway.

Neurochemical research

Wei X,Huang C,Chen K,Liu S,Wang M,Yang L,Wang Y

Fri Sep 01 00:00:00 UTC 2023

A coordinated multiorgan metabolic response contributes to human mitochondrial myopathy.

EMBO molecular medicine

Southwell N,Primiano G,Nadkarni V,Attarwala N,Beattie E,Miller D,Alam S,Liparulo I,Shurubor YI,Valentino ML,Carelli V,Servidei S,Gross SS,Manfredi G,Chen Q,D'Aurelio M

Mon Jul 10 00:00:00 UTC 2023

Arthritic Microenvironment Actuated Nanomotors for Active Rheumatoid Arthritis Therapy.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

Xu C,Jiang Y,Wang H,Zhang Y,Ye Y,Qin H,Gao J,Dan Q,Du L,Liu L,Peng F,Li Y,Tu Y

Wed Feb 01 00:00:00 UTC 2023

Deferoxamine prevents poststroke memory impairment in female diabetic rats: potential links to hemorrhagic transformation and ferroptosis.

American journal of physiology. Heart and circulatory physiology

Li W,Abdul Y,Chandran R,Jamil S,Ward RA,Abdelsaid M,Dong G,Fagan SC,Ergul A

Wed Feb 01 00:00:00 UTC 2023

Targeting of Annexin A1 in Tumor-associated Macrophages as a therapeutic strategy for hepatocellular carcinoma.

Biochemical pharmacology

Song Z,Wang X,Liu X,Luo Y,Qiu J,Yin A,Liu Y,Yi H,Xiao Z,Li A

Sat Jul 01 00:00:00 UTC 2023

ALA-PDT regulates macrophage M1 polarization via ERK/MAPK-NLRP3 pathway to promote the early inflammatory response.

Lasers in surgery and medicine

Wang L,Zhang W,Cen R,Yue C,Xiao T,Deng Y,Li L,Sun K,Lei X

Thu Dec 01 00:00:00 UTC 2022

Apelin alleviated neuroinflammation and promoted endogenous neural stem cell proliferation and differentiation after spinal cord injury in rats.

Journal of neuroinflammation

Liu Q,Zhou S,Wang X,Gu C,Guo Q,Li X,Zhang C,Zhang N,Zhang L,Huang F

Mon Jun 20 00:00:00 UTC 2022

Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice.

Cell death & disease

Ni L,Xiao J,Zhang D,Shao Z,Huang C,Wang S,Wu Y,Tian N,Sun L,Wu A,Zhou Y,Wang X,Zhang X

Thu Feb 10 00:00:00 UTC 2022

Immune-responsive gene 1/itaconate activates nuclear factor erythroid 2-related factor 2 in microglia to protect against spinal cord injury in mice.

Cell death & disease

Ni L,Xiao J,Zhang D,Shao Z,Huang C,Wang S,Wu Y,Tian N,Sun L,Wu A,Zhou Y,Wang X,Zhang X

Thu Feb 10 00:00:00 UTC 2022

Neuroglobin alleviates the neurotoxicity of sevoflurane to fetal rats by inhibiting neuroinflammation and affecting microglial polarization.

Brain research bulletin

Zhang Y,Gao Y,Yang F,Wu X,Tang Z,Liu H

Wed Jun 01 00:00:00 UTC 2022

microRNA-155-3p delivered by M2 macrophages-derived exosomes enhances the progression of medulloblastoma through regulation of WDR82.

Journal of translational medicine

Song L,Luan B,Xu Q,Shi R,Wang X

Tue Jan 04 00:00:00 UTC 2022

Macrophage depletion blocks congenital SARM1-dependent neuropathy.

The Journal of clinical investigation

Dingwall CB,Strickland A,Yum SW,Yim AK,Zhu J,Wang PL,Yamada Y,Schmidt RE,Sasaki Y,Bloom AJ,DiAntonio A,Milbrandt J

Thu Dec 01 00:00:00 UTC 2022

Aloe polymeric acemannan inhibits the cytokine storm in mouse pneumonia models by modulating macrophage metabolism.

Carbohydrate polymers

Li L,Xu W,Luo Y,Lao C,Tong X,Du J,Huang B,Li D,Chen J,Ye H,Cong F,Guo X,Li J

Thu Dec 01 00:00:00 UTC 2022

Aloe polymeric acemannan inhibits the cytokine storm in mouse pneumonia models by modulating macrophage metabolism.

Carbohydrate polymers

Li L,Xu W,Luo Y,Lao C,Tong X,Du J,Huang B,Li D,Chen J,Ye H,Cong F,Guo X,Li J

Thu Dec 01 00:00:00 UTC 2022

Aloe polymeric acemannan inhibits the cytokine storm in mouse pneumonia models by modulating macrophage metabolism.

Carbohydrate polymers

Li L,Xu W,Luo Y,Lao C,Tong X,Du J,Huang B,Li D,Chen J,Ye H,Cong F,Guo X,Li J

Thu Dec 01 00:00:00 UTC 2022

Itaconate attenuates osteoarthritis by inhibiting STING/NF-κB axis in chondrocytes and promoting M2 polarization in macrophages.

Biochemical pharmacology

Ni L,Lin Z,Hu S,Shi Y,Jiang Z,Zhao J,Zhou Y,Wu Y,Tian N,Sun L,Wu A,Pan Z,Zhang X,Wang X

Fri Apr 01 00:00:00 UTC 2022

Exosomes Derived From M2 Microglia Cells Attenuates Neuronal Impairment and Mitochondrial Dysfunction in Alzheimer's Disease Through the PINK1/Parkin Pathway.

Frontiers in cellular neuroscience

Li N,Shu J,Yang X,Wei W,Yan A

Thu May 19 00:00:00 UTC 2022

Exosomes Derived From M2 Microglia Cells Attenuates Neuronal Impairment and Mitochondrial Dysfunction in Alzheimer's Disease Through the PINK1/Parkin Pathway.

Frontiers in cellular neuroscience

Li N,Shu J,Yang X,Wei W,Yan A

Thu May 19 00:00:00 UTC 2022

The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.

Journal of neuroinflammation

Kou L,Chi X,Sun Y,Han C,Wan F,Hu J,Yin S,Wu J,Li Y,Zhou Q,Zou W,Xiong N,Huang J,Xia Y,Wang T

Mon Jun 06 00:00:00 UTC 2022

The circadian clock protein Rev-erbα provides neuroprotection and attenuates neuroinflammation against Parkinson's disease via the microglial NLRP3 inflammasome.

Journal of neuroinflammation

Kou L,Chi X,Sun Y,Han C,Wan F,Hu J,Yin S,Wu J,Li Y,Zhou Q,Zou W,Xiong N,Huang J,Xia Y,Wang T

Mon Jun 06 00:00:00 UTC 2022

Exploration of the potential mechanism of Pushen capsule in the treatment of vascular dementia based on network pharmacology and experimental verification.

Journal of ethnopharmacology

Liu Y,Li S,Liu D,Wei H,Wang X,Yan F

Tue Nov 15 00:00:00 UTC 2022

Melatonin ameliorates Parkinson's disease via regulating microglia polarization in a RORα-dependent pathway.

NPJ Parkinson's disease

Li J,Liu H,Wang X,Xia Y,Huang J,Wang T,Lin Z,Xiong N

Fri Jul 08 00:00:00 UTC 2022

The P300/XBP1s/Herpud1 axis promotes macrophage M2 polarization and the development of choroidal neovascularization.

Journal of cellular and molecular medicine

Li W,Wang Y,Zhu L,Du S,Mao J,Wang Y,Wang S,Bo Q,Tu Y,Yi Q

Thu Jul 01 00:00:00 UTC 2021

Ruyiping extract reduces lung metastasis in triple negative breast cancer by regulating macrophage polarization.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Yang R,Xie Y,Li Q,Ye Y,Shi Y,Zhao X,Wu C,Xu Y,Wang R,Zhang Y,Yang X,Han X,Liu S

Wed Sep 01 00:00:00 UTC 2021

Rosuvastatin Nanomicelles Target Neuroinflammation and Improve Neurological Deficit in a Mouse Model of Intracerebral Hemorrhage.

International journal of nanomedicine

Zi L,Zhou W,Xu J,Li J,Li N,Xu J,You C,Wang C,Tian M

Tue Jun 01 00:00:00 UTC 2021

Reactive astrocytes induced by 2-chloroethanol modulate microglia polarization through IL-1β, TNF-α, and iNOS upregulation.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Wang T,Sun Q,Yang J,Wang G,Zhao F,Chen Y,Jin Y

Mon Nov 01 00:00:00 UTC 2021

The Cholinergic Anti-Inflammatory Pathway Attenuates the Development of Atherosclerosis in Mice through Modulating Macrophage Functions.

Biomedicines

Qian Z,Yang H,Li H,Liu C,Yang L,Qu Z,Li X

Fri Sep 03 00:00:00 UTC 2021

Deferoxamine Treatment Prevents Post-Stroke Vasoregression and Neurovascular Unit Remodeling Leading to Improved Functional Outcomes in Type 2 Male Diabetic Rats: Role of Endothelial Ferroptosis.

Translational stroke research

Abdul Y,Li W,Ward R,Abdelsaid M,Hafez S,Dong G,Jamil S,Wolf V,Johnson MH,Fagan SC,Ergul A

Sun Aug 01 00:00:00 UTC 2021

Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.

Immunity

Lou F,Sun Y,Xu Z,Niu L,Wang Z,Deng S,Liu Z,Zhou H,Bai J,Yin Q,Cai X,Sun L,Wang H,Li Q,Wu Z,Chen X,Gu J,Shi YL,Tao W,Ginhoux F,Wang H

Tue Jul 14 00:00:00 UTC 2020

Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.

Immunity

Lou F,Sun Y,Xu Z,Niu L,Wang Z,Deng S,Liu Z,Zhou H,Bai J,Yin Q,Cai X,Sun L,Wang H,Li Q,Wu Z,Chen X,Gu J,Shi YL,Tao W,Ginhoux F,Wang H

Tue Jul 14 00:00:00 UTC 2020

Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.

Immunity

Lou F,Sun Y,Xu Z,Niu L,Wang Z,Deng S,Liu Z,Zhou H,Bai J,Yin Q,Cai X,Sun L,Wang H,Li Q,Wu Z,Chen X,Gu J,Shi YL,Tao W,Ginhoux F,Wang H

Tue Jul 14 00:00:00 UTC 2020

Excessive Polyamine Generation in Keratinocytes Promotes Self-RNA Sensing by Dendritic Cells in Psoriasis.

Immunity

Lou F,Sun Y,Xu Z,Niu L,Wang Z,Deng S,Liu Z,Zhou H,Bai J,Yin Q,Cai X,Sun L,Wang H,Li Q,Wu Z,Chen X,Gu J,Shi YL,Tao W,Ginhoux F,Wang H

Tue Jul 14 00:00:00 UTC 2020

Intravenously Infusing the Secretome of Adipose-Derived Mesenchymal Stem Cells Ameliorates Neuroinflammation and Neurological Functioning After Traumatic Brain Injury.

Stem cells and development

Xu C,Diao YF,Wang J,Liang J,Xu HH,Zhao ML,Zheng B,Luan Z,Wang JJ,Yang XP,Wei MG,Duan JH,Wang KQ,Chen C,Chen F,Ming D,Zhang S,Sun HT,Li XH

Sat Feb 15 00:00:00 UTC 2020

Injectable Gelatin Hydrogel Suppresses Inflammation and Enhances Functional Recovery in a Mouse Model of Intracerebral Hemorrhage.

Frontiers in bioengineering and biotechnology

Xu J,Duan Z,Qi X,Ou Y,Guo X,Zi L,Wei Y,Liu H,Ma L,Li H,You C,Tian M

Fri Mar 29 00:00:00 UTC 2024

Neuroprotective Effect of Ketone Metabolism on Inhibiting Inflammatory Response by Regulating Macrophage Polarization After Acute Cervical Spinal Cord Injury in Rats.

Frontiers in neuroscience

Lin J,Huang Z,Liu J,Huang Z,Liu Y,Liu Q,Yang Z,Li R,Wu X,Shi Z,Zhu Q,Wu X

Mon Apr 18 00:00:00 UTC 2022

Lipoxin A4 Regulates Lipopolysaccharide-Induced BV2 Microglial Activation and Differentiation via the Notch Signaling Pathway.

Frontiers in cellular neuroscience

Wu J,Ding DH,Li QQ,Wang XY,Sun YY,Li LJ

Tue Sep 29 00:00:00 UTC 2020

Effects of exposure of adult mice to multi-walled carbon nanotubes on the liver lipid metabolism of their offspring.

Toxicology research

Zhang HY,Chen RL,Shao Y,Wang HL,Liu ZG

Sat Sep 01 00:00:00 UTC 2018

Involvement of JNK signaling in IL4-induced M2 macrophage polarization.

Experimental cell research

Hao J,Hu Y,Li Y,Zhou Q,Lv X

Tue Aug 15 00:00:00 UTC 2017

Involvement of JNK signaling in IL4-induced M2 macrophage polarization.

Experimental cell research

Hao J,Hu Y,Li Y,Zhou Q,Lv X

Tue Aug 15 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: A-I; AI type I arginase; Arginase; arginase 1 liver; arginase 1, liver; arginase I; arginase, liver; Arginase-1; Arginase1; HGNC:663; Liver Arginase; Liver-type arginase; Type 1 Arginase; Type I arginase

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Gene Aliases: AI; AI256583; Arg-1; ARG1; PGIF

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UniProt ID: (Pig) Q95JC8, (Human) P05089, (Rat) P07824, (Mouse) Q61176

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Entrez Gene ID: (Pig) 397115, (Human) 383, (Rat) 29221, (Mouse) 11846

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Function(s)

arginase activity manganese ion binding hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines metal ion binding

Process(es)

urea cycle liver development positive regulation of endothelial cell proliferation arginine metabolic process female pregnancy aging response to wounding response to herbicide response to manganese ion response to zinc ion response to selenium ion regulation of L-arginine import response to amine arginine catabolic process to ornithine lung development response to lipopolysaccharide collagen biosynthetic process response to vitamin A response to vitamin E response to drug response to amino acid response to peptide hormone response to cadmium ion response to steroid hormone response to axon injury response to methylmercury mammary gland involution maternal process involved in female pregnancy protein homotrimerization cellular response to hydrogen peroxide cellular response to lipopolysaccharide cellular response to interleukin-4 cellular response to glucagon stimulus cellular response to dexamethasone stimulus cellular response to transforming growth factor beta stimulus arginine catabolic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ARG1 Monoclonal Antibody (5D6D12)

ARG1 Antibody (66129-1-IG) in IHC (P)

Product Details

66129-1-IG

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Clone

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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