Proteintech

ARG2 Polyclonal Antibody

ARG2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ARG2 Antibody (14825-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded human prostate cancer tissue slide using (Product # 14825-1-AP) (ARG2 antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

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Product Details

14825-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (IHC)

View 2 publications 2 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ARG2 Fusion Protein Ag6609 (1-354 aa encoded by BC001350)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.39 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MSLRGSLSR LLQTRVHSIL KKSVHSVAVI GAPFSQGQKR KGVEHGPAAI REAGLMKRLS SLGCHLKDFG DLSFTPVPKD DLYNNLIVNP RSVGLANQEL AEVVSRAVSD GYSCVTLGGD HSLAIGTISG HARHCPDLCV VWVDAHADIN TPLTTSSGNL HGQPVSFLLR ELQDKVPQLP GFSWIKPCIS SASIVYIGLR DVDPPEHFIL KNYDIQYFSM RDIDRLGIQK VMERTFDLLI GKRQRPIHLS FDIDAFDPTL APATGTPVVG GLTYREGMYI AEEIHNTGLL SALDLVEVNP QLATSEEEAK TTANLAVDVI ASSFGQTREG GHIVYDQLPT PSSPDESENQ ARVRI (1-354 aa encoded by BC001350)

Target Information

Arginase catalyzes the hydrolysis of arginine to ornithine and urea. At least two isoforms of mammalian arginase exists (types I and II) which differ in their tissue distribution, subcellular localization, immunologic crossreactivity and physiologic function. The type II isoform encoded by this gene, is located in the mitochondria and expressed in extra-hepatic tissues, especially kidney. The physiologic role of this isoform is poorly understood; it is thought to play a role in nitric oxide and polyamine metabolism. Transcript variants of the type II gene resulting from the use of alternative polyadenylation sites have been described.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Progesterone and interferon tau regulate expression of polyamine enzymes during the ovine peri-implantation period†.

Biology of reproduction

Halloran KM,Stenhouse C,Moses RM,Seo H,Johnson GA,Wu G,Bazer FW

Tue May 17 00:00:00 UTC 2022

Combination of L-Arginine and L-Norvaline protects against pulmonary fibrosis progression induced by bleomycin in mice.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

Gao L,Zhang JH,Chen XX,Ren HL,Feng XL,Wang JL,Xiao JH

Wed May 01 00:00:00 UTC 2019

PTPN2 improved renal injury and fibrosis by suppressing STAT-induced inflammation in early diabetic nephropathy.

Journal of cellular and molecular medicine

Li Y,Zhou H,Li Y,Han L,Song M,Chen F,Shang G,Wang D,Wang Z,Zhang W,Zhong M

Sat Jun 01 00:00:00 UTC 2019

PTPN2 improved renal injury and fibrosis by suppressing STAT-induced inflammation in early diabetic nephropathy.

Journal of cellular and molecular medicine

Li Y,Zhou H,Li Y,Han L,Song M,Chen F,Shang G,Wang D,Wang Z,Zhang W,Zhong M

Sat Jun 01 00:00:00 UTC 2019

Deletion of Macrophage Low-Density Lipoprotein Receptor-Related Protein 1 (LRP1) Accelerates Atherosclerosis Regression and Increases C-C Chemokine Receptor Type 7 (CCR7) Expression in Plaque Macrophages.

Circulation

Mueller PA,Zhu L,Tavori H,Huynh K,Giunzioni I,Stafford JM,Linton MF,Fazio S

Tue Oct 23 00:00:00 UTC 2018

Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model.

Biochimica et biophysica acta. Molecular basis of disease

Bichell TJV,Wegrzynowicz M,Tipps KG,Bradley EM,Uhouse MA,Bryan M,Horning K,Fisher N,Dudek K,Halbesma T,Umashanker P,Stubbs AD,Holt HK,Kwakye GF,Tidball AM,Colbran RJ,Aschner M,Neely MD,Di Pardo A,Maglione V,Osmand A,Bowman AB

Thu Jun 01 00:00:00 UTC 2017

Reduced bioavailable manganese causes striatal urea cycle pathology in Huntington's disease mouse model.

Biochimica et biophysica acta. Molecular basis of disease

Thu Jun 01 00:00:00 UTC 2017

Ornithine is a key mediator in hyperphosphatemia-mediated human umbilical vein endothelial cell apoptosis: Insights gained from metabolomics.

Life sciences

Zhou R,Kang X,Tang B,Mohan C,Wu T,Peng A,Liu JY

Mon Feb 01 00:00:00 UTC 2016

Ornithine is a key mediator in hyperphosphatemia-mediated human umbilical vein endothelial cell apoptosis: Insights gained from metabolomics.

Life sciences

Zhou R,Kang X,Tang B,Mohan C,Wu T,Peng A,Liu JY

Mon Feb 01 00:00:00 UTC 2016

Macrophage-derived apoESendai suppresses atherosclerosis while causing lipoprotein glomerulopathy in hyperlipidemic mice.

Journal of lipid research

Tavori H,Fan D,Giunzioni I,Zhu L,Linton MF,Fogo AB,Fazio S

Wed Oct 01 00:00:00 UTC 2014

Macrophage-derived apoESendai suppresses atherosclerosis while causing lipoprotein glomerulopathy in hyperlipidemic mice.

Journal of lipid research

Tavori H,Fan D,Giunzioni I,Zhu L,Linton MF,Fogo AB,Fazio S

Wed Oct 01 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: AII type II arginase; Arginase II; arginase type II; arginase, type II; Arginase-2, mitochondrial; kidney arginase; Kidney-type arginase; L-arginine amidinohydrolase; L-arginine ureahydrolase; Non-hepatic arginase; nonhepatic arginase; Type II arginase

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Gene Aliases: AII; ARG2; AU022422

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UniProt ID: (Human) P78540, (Rat) O08701, (Mouse) O08691

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Entrez Gene ID: (Human) 384, (Rat) 29215, (Mouse) 11847

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Function(s)

arginase activity metal ion binding protein binding nitric-oxide synthase binding hydrolase activity hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines

Process(es)

urea cycle ureteric bud development response to hypoxia arginine metabolic process apoptotic process striated muscle contraction midgut development response to nutrient response to herbicide response to hormone response to glucose response to selenium ion regulation of L-arginine import response to amine arginine catabolic process to ornithine lung development response to vitamin E response to drug response to amino acid regulation of nitric oxide biosynthetic process negative regulation of striated muscle contraction response to cadmium ion response to mercury ion response to axon injury negative regulation of nitric-oxide synthase activity maternal process involved in female pregnancy cellular response to lipopolysaccharide cellular response to interferon-gamma cellular response to interleukin-4 cellular response to dexamethasone stimulus nitric oxide biosynthetic process

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ARG2 Polyclonal Antibody

ARG2 Antibody (14825-1-AP) in IHC (P)

Product Details

14825-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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