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ARHGAP10 Polyclonal Antibody

ARHGAP10 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ARHGAP10 Antibody (55139-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human skeletal muscle tissue slide using 55139-1-AP (ARHGAP10 Antibody) at dilution of 1:200 (under 40x lens).

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Product Details

55139-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 7 publications 7 publications

Immunohistochemistry (IHC)

View 4 publications 4 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.4 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The antibody is specific to ARHGAP10.

Target Information

GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Enhanced BCAT1 activity and BCAA metabolism promotes RhoC activity in cancer progression.

Nature metabolism

Qian L,Li N,Lu XC,Xu M,Liu Y,Li K,Zhang Y,Hu K,Qi YT,Yao J,Wu YL,Wen W,Huang S,Chen ZJ,Yin M,Lei QY

Sat Jul 01 00:00:00 UTC 2023

Rho GTPase-activating protein 10 (ARHGAP10/GRAF2) is a novel autoantibody target in patients with autoimmune encephalitis.

Journal of neurology

Jarius S,Komorowski L,Regula JU,Haas J,Brakopp S,Wildemann B

Sat Oct 01 00:00:00 UTC 2022

Identification and Validation of an Apoptosis-Related Gene Prognostic Signature for Oral Squamous Cell Carcinoma.

Frontiers in oncology

Wang S,Zhang S,Lin Z,Ma J,Zhu L,Liao G

Sat Jul 16 00:00:00 UTC 2022

The Beta-Tubulin Isotype TUBB6 Controls Microtubule and Actin Dynamics in Osteoclasts.

Frontiers in cell and developmental biology

Maurin J,Morel A,Guérit D,Cau J,Urbach S,Blangy A,Bompard G

Tue Dec 07 00:00:00 UTC 2021

miR‑337‑3p inhibits gastric tumor metastasis by targeting ARHGAP10.

Molecular medicine reports

Wang Z,Yao L,Li Y,Hao B,Wang M,Wang J,Gu W,Zhan H,Liu G,Wu Q

Sat Feb 01 00:00:00 UTC 2020

miR‑337‑3p inhibits gastric tumor metastasis by targeting ARHGAP10.

Molecular medicine reports

Wang Z,Yao L,Li Y,Hao B,Wang M,Wang J,Gu W,Zhan H,Liu G,Wu Q

Sat Feb 01 00:00:00 UTC 2020

ARHGAP10 Inhibits the Proliferation and Metastasis of CRC Cells via Blocking the Activity of RhoA/AKT Signaling Pathway.

OncoTargets and therapy

Liu L,Xie D,Xie H,Huang W,Zhang J,Jin W,Jiang W,Xie D

Tue Apr 12 00:00:00 UTC 2022

Downregulated expression of ARHGAP10 correlates with advanced stage and high Ki-67 index in breast cancer.

PeerJ

Li Y,Zeng B,Li Y,Zhang C,Ren G

Sat Apr 09 00:00:00 UTC 2022

Downregulated expression of ARHGAP10 correlates with advanced stage and high Ki-67 index in breast cancer.

PeerJ

Li Y,Zeng B,Li Y,Zhang C,Ren G

Sat Apr 09 00:00:00 UTC 2022

miR-3174 Contributes to Apoptosis and Autophagic Cell Death Defects in Gastric Cancer Cells by Targeting ARHGAP10.

Molecular therapy. Nucleic acids

Li B,Wang L,Li Z,Wang W,Zhi X,Huang X,Zhang Q,Chen Z,Zhang X,He Z,Xu J,Zhang L,Xu H,Zhang D,Xu Z

Fri Dec 15 00:00:00 UTC 2017

miR-3174 Contributes to Apoptosis and Autophagic Cell Death Defects in Gastric Cancer Cells by Targeting ARHGAP10.

Molecular therapy. Nucleic acids

Li B,Wang L,Li Z,Wang W,Zhi X,Huang X,Zhang Q,Chen Z,Zhang X,He Z,Xu J,Zhang L,Xu H,Zhang D,Xu Z

Fri Dec 15 00:00:00 UTC 2017

The Cdc42 guanine nucleotide exchange factor FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts.

The Journal of biological chemistry

Steenblock C,Heckel T,Czupalla C,Espírito Santo AI,Niehage C,Sztacho M,Hoflack B

Fri Jun 27 00:00:00 UTC 2014

The Cdc42 guanine nucleotide exchange factor FGD6 coordinates cell polarity and endosomal membrane recycling in osteoclasts.

The Journal of biological chemistry

Steenblock C,Heckel T,Czupalla C,Espírito Santo AI,Niehage C,Sztacho M,Hoflack B

Fri Jun 27 00:00:00 UTC 2014

Bioinformatics

Protein Aliases: Graf-related protein 2; GRAF2; GTPase regulator associated with focal adhesion kinase 2; PH and SH3 domain-containing rhoGAP protein; PS-GAP; PSGAP; Rho GTPase-activating protein 10; Rho-type GTPase-activating protein 10

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Gene Aliases: A930033B01Rik; ARHGAP10; GRAF2; PS-GAP; PSGAP; PSGAP-m; PSGAP-s

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UniProt ID: (Human) A1A4S6, (Mouse) Q6Y5D8

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Entrez Gene ID: (Human) 79658, (Mouse) 78514

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Function(s)

GTPase activator activity protein binding

Process(es)

cytoskeleton organization signal transduction negative regulation of apoptotic process positive regulation of GTPase activity regulation of small GTPase mediated signal transduction

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ARHGAP10 Polyclonal Antibody

ARHGAP10 Antibody (55139-1-AP) in IHC (P)

Product Details

55139-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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