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Product Details
PA5-56790
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ARHGAP18. Recombinant protein control fragment (Product #RP-94893).
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2638136
Product Specific Information
Immunogen sequence: STTIKVMEKP PFDRSISQDS LDELSMEDYW IELENIKKSS ENSQEDQEVV VVKEPDEGEL EEEWLKEAGL SNLFGESAGD PQESI
Highest antigen sequence identity to the following orthologs: Mouse - 79%, Rat - 78%.
Target Information
ARHGAP18 is one member of the human RhoGAP family with approximately 80 RhoGAP proteins known to be encoded in the human genome. Rho proteins belong to the Ras superfamily that is composed of over 50 members divided into six families, including Ras, Sar, Rho, Ran, Rab and Arf. Rho GTPases are important regulators of the actin cytoskeleton and consequently influence the shape and migration of cells. ARHGAP18 is linked to Ras, and thus, to EGFR-mediated proliferation, migration and differentiation. ARHGAP18 is precisely contained within chromosome 6q22-24, which has been shown to be linked to schizophrenia, suggesting that ARHGEP18 may play a role in this condition.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARHGAP18; MacGAP; Rho GTPase-activating protein 18; Rho-type GTPase-activating protein 18
Gene Aliases: ARHGAP18; bA307O14.2; MacGAP; SENEX
UniProt ID: (Human) Q8N392
Entrez Gene ID: (Human) 93663
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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