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Product Details
PA5-104266
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ARHGAP22(Accession Q7Z5H3), corresponding to amino acid residues L564-R614.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2853577
Product Specific Information
Antibody detects endogenous levels of total ARHGAP22.
Target Information
GTPase-activating proteins (GAPs) accelerate the intrinsic rate of GTP hydrolysis of Ras-related proteins, resulting in down regulation of their active form. ARHGAP22 (Rho GTPase activating protein 22), also known as RHOGAP2, is a 698 amino acid protein that localizes to the cytoplasm, and contains one Rho-GAP domain and one PH domain. ARHGAP22 functions as a GTPase-activating protein for Rac 1 converting it to an inactive GDP-bound state and, through its interaction with ZNF161 (VEZF1), is thought to be useful in transcription regulation. Multiple isoforms of ARHGAP22 exist due to alternative splicing events.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: p68RacGAP; RHG22; Rho GTPase-activating protein 22; Rho-type GTPase-activating protein 22
Gene Aliases: ARHGAP22; B230341L19Rik; p68RacGAP; RHOGAP2; RhoGap22
UniProt ID: (Human) Q7Z5H3, (Mouse) Q8BL80
Entrez Gene ID: (Human) 58504, (Mouse) 239027
Performance Guarantee
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