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Abnova
ARHGAP24 Polyclonal Antibody, MaxPab™
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Product Details
H00083478-B01P
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ARHGAP24 (NP_001036134.1, 1 a.a. approximately 653 a.a) full-length human protein.
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Product may be used with Western Blot (Transfected lysate).
The Isotype of this product is composed of an IgG Mixture.
Immunogen sequence: MTANHESYLL MASTQNDMED WVKSIRRVIW GPFGGGIFGQ KLEDTVRYEK RYGNRLAPML VEQCVDFIRQ RGLKEEGLFR LPGQANLVKE LQDAFDCGEK PSFDSNTDVH TVASLLKLYL RELPEPVIPY AKYEDFLSCA KLLSKEEEAG VKELAKQVKS LPVVNYNLLK YICRFLDEVQ SYSGVNKMSV QNLATVFGPN ILRPKVEDPL TIMEGTVVVQ QLMSVMISKH DCLFPKDAEL QSKPQDGVSN NNEIQKKATM GQLQNKENNN TKDSPSRQCS WDKSESPQRS SMNNGSPTAL SGSKTNSPKN SVHKLDVSRS PPLMVKKNPA FNKGSGIVTN GSFSSSNAEG LEKTQTTPNG SLQARRSSSL KVSGTKMGTH SVQNGTVRMG ILNSDTLGNP TNVRNMSWLP NGYVTLRDNK QKEQAGELGQ HNRLSTYDNV HQQFSMMNLD DKQSIDSATW STSSCEISLP ENSNSCRSST TTCPEQDFFG GNFEDPVLDG PPQDDLSHPR DYESKSDHRS VGGRSSRATS SSDNSETFVG NSSSNHSALH SLVSSLKQEM TKQKIEYESR IKSLEQRNLT LETEMMSLHD ELDQERKKFT MIEIKMRNAE RAKEDAEKRN DMLQKEMEQF FSTFGELTVE PRRTERGNTI WIQ
Target Information
Rho GTPase-activating protein involved in cell polarity, cell morphology and cytoskeletal organization. Acts as a GTPase activator for the Rac-type GTPase by converting it to an inactive GDP-bound state. Controls actin remodeling by inactivating Rac downstream of Rho leading to suppress leading edge protrusion and promotes cell retraction to achieve cellular polarity. Able to suppress RAC1 and CDC42 activity in vitro. Overexpression induces cell rounding with partial or complete disruption of actin stress fibers and formation of membrane ruffles, lamellipodia, and filopodia. Isoform 2 is a vascular cell-specific GAP involved in modulation of angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Filamin-A-associated RhoGAP; FilGAP; p73RhoGAP; RAC1- and CDC42-specific GTPase-activating protein of 72 kDa; RC-GAP72; Rho GTPase-activating protein 24; Rho-type GTPase-activating protein 24; RhoGAP of 73 kDa; Sarcoma antigen NY-SAR-88
Gene Aliases: ARHGAP24; FILGAP; p73; p73RhoGAP; RC-GAP72; RCGAP72
UniProt ID: (Human) Q8N264
Entrez Gene ID: (Human) 83478
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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