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Product Details
PA5-58365
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human p190-A RhoGAP. Recombinant protein control fragment (Product #RP-102828).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2645136
Product Specific Information
Immunogen sequence: AVATTEDNLS SSYSAVALDK AYFQTDRPAE QFHLQNNAPG NCDHPLPETT ATGDPTHSNT TESGEQHHQV DLTGNQPHQA YLSGDPEKAR ITSVP
Highest antigen sequence identity to the following orthologs: Mouse - 65%, Rat - 74%.
Target Information
GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: brain-specific Rho GTP-ase-activating protein; Brain-specific Rho GTPase-activating protein; GAB-associated CDC42; GAB-associated Cdc42/Rac GTPase-activating protein; GC-GAP; GTPase regulator interacting with TrkA; GTPase-activating protein for Cdc42 and Rac1; p200RhoGAP; p250GAP; rac GTPase activating protein; Rho GTPase-activating protein 32; Rho-type GTPase-activating protein 32; Rho/Cdc42/Rac GTPase-activating protein RICS; RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signaling; RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling
Gene Aliases: ARHGAP32; GC-GAP; GRIT; KIAA0712; p200RhoGAP; p250GAP; PX-RICS; RICS
UniProt ID: (Human) A7KAX9
Entrez Gene ID: (Human) 9743
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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