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Immunogen sequence: YLNKLLSSG SRYLIRSDDM IETVYNDRGE IVKTKERRVF MLNDVLMCAT VSSRPSHDSR VMSSQRYLLK WSVPLGHVDA IEYGSSAGTG EHSRHLAVHP PESLAVVANA KPNKVYMGPG QLYQDLQNLL HDLNVIGQIT QLIGNLKGNY QNLNQSVAHD WTSGLQRLIL KKEDEIRAAD CCRIQLQLPG KQDKSGRPTF FTAVFNTFTP AIKESWVNSL QMAKLALEEN HMGWFCVEDD GNHIKKEKHP LLVGHMPVMV AKQQEFKIEC AAYNPEPYLN NESQPDSFST AHGFLWVRCV Y (342-641 aa encoded by BC036809)
This gene encodes a Rho guanine nucleotide exchange factor (GEF). Rho GEFs regulate the activity of small Rho GTPases by stimulating the exchange of guanine diphosphate (GDP) for guanine triphosphate (GTP) and may play a role in neural morphogenesis. Mutations in this gene are associated with slowed nerve conduction velocity (SNCV). Alternative splicing results in multiple transcript variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Rho guanine nucleotide exchange factor (GEF) 10; Rho guanine nucleotide exchange factor 10
Gene Aliases: 6430549H08Rik; ARHGEF10; GEF10; KIAA0294; mKIAA0294; RGD1565043; SNCV
UniProt ID: (Human) O15013, (Mouse) Q8C033
Entrez Gene ID: (Human) 9639, (Mouse) 234094, (Rat) 306618
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