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Product Details
11243-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ARHGEF18 Fusion Protein Ag1749 (1-89 aa encoded by BC014994)
Conjugate
Form
Liquid
Concentration
0.25 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MSQGMQRMH LETLQQVDKW PLCGPLACSE LLQLTVRSLE GWRKEVLGSI KGAGTSQGGE IHPRSSSGGE RAHVKPCSAP QALVVGLGPG (1-89 aa encoded by BC014994 )
Target Information
Rho GTPases are GTP binding proteins that regulate a wide spectrum of cellular functions. These cellular processes include cytoskeletal rearrangements, gene transcription, cell growth and motility. Activation of Rho GTPases is under the direct control of guanine nucleotide exchange factors (GEFs). The protein encoded by this gene is a guanine nucleotide exchange factor and belongs to the Rho GTPase GFE family. Family members share a common feature, a Dbl (DH) homology domain followed by a pleckstrin (PH) homology domain. Alternatively spliced transcript variants encoding different isoforms have been identified.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 114 kDa Rho-specific guanine nucleotide exchange factor; p114-Rho-GEF; p114RhoGEF; Rho guanine nucleotide exchange factor 18; Rho-specific guanine nucleotide exchange factor p114; Rho/Rac guanine nucleotide exchange factor (GEF) 18; SA-RhoGEF; Septin-associated RhoGEF
Gene Aliases: AI467246; ARHGEF18; D030053O22Rik; KIAA0521; P114-RhoGEF
UniProt ID: (Human) Q6ZSZ5, (Mouse) Q6P9R4
Entrez Gene ID: (Human) 23370, (Mouse) 102098
transforming growth factor beta receptor signaling pathway
small GTPase mediated signal transduction
regulation of cell shape
actin cytoskeleton organization
regulation of Rho protein signal transduction
positive regulation of apoptotic process
positive regulation of GTPase activity
regulation of small GTPase mediated signal transduction
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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