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Product Details
ARHGEF7-701AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide taken within amino acid region 595-805 on human ARHGEF7 protein.
Conjugate
Form
Liquid
Concentration
0.5-1.5 mg/mL
Purification
Affinity chromatography
Storage buffer
proprietary buffer, pH 7.4-7.8, with 30% glycerol, 0.5% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Target Information
The serine/threonine kinase, p21 activated kinase (PAK), is a downstream effector of the small GTPases Cdc42 and Rac. PAK associates with Nck, the p85 and p110 subunits of PI3-kinase and PIX (PAK-interacting exchange factor) in a focal complex. The binding of PIX is necessary for the localization and activation of PAK in the Cdc42 to Rac signaling pathway, and this binding occurs through the high affinity of the N-terminal SH3 domain of PIX for a conserved proline rich PAK sequence. PIX exists as two isoforms, alpha and beta, and both are highly expressed in heart, muscle and thymus tissues of human and rat. alphaPIX is phosphorylated via PDGF and EphB2 receptor signaling pathways or through association with PI3-kinase. The alphaPIX isoform predominantly acts as a guanine nucleotide exchange factor (GEF) on Rac, which may mediate lamellipodia formation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Beta-Pix; COOL-1; p85; p85SPR; PAK-interacting exchange factor beta; Pak3 binding protein; PIXbeta; Rho guanine nucleotide exchange factor (GEF) 7; Rho guanine nucleotide exchange factor 7; SH3 domain-containing proline-rich protein
Gene Aliases: ARHGEF7; BETA-PIX; betaPix; betaPix-b; betaPix-c; Cool; COOL-1; COOL1; KIAA0142; mKIAA0142; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PAK3; PAK3BP; PIX; PIXB
UniProt ID: (Human) Q14155, (Rat) O55043, (Mouse) Q9ES28
Entrez Gene ID: (Human) 8874, (Rat) 114559, (Mouse) 54126
hematopoietic progenitor cell differentiation
small GTPase mediated signal transduction
positive regulation of fibroblast migration
lamellipodium assembly
intracellular signal transduction
positive regulation of apoptotic process
positive regulation of GTPase activity
astrocyte cell migration
focal adhesion assembly
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of lamellipodium morphogenesis
nervous system development
positive regulation of protein binding
regulation of Rho protein signal transduction
positive regulation of growth hormone secretion
Golgi organization
signal transduction
negative regulation of epidermal growth factor receptor signaling pathway
ephrin receptor signaling pathway
regulation of small GTPase mediated signal transduction
regulation of GTP binding
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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