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Invitrogen
ARID5B Polyclonal Antibody
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Product Details
PA5-107065
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Synthetic peptide directed towards the N-terminal region of Human ARID5B
Conjugate
Form
Liquid
Concentration
0.5 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.4, with 2% sucrose
Contains
0.09% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Wet ice
RRID
AB_2817781
Product Specific Information
Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%
Target Information
ARID5B encodes a member of the AT-rich interaction domain (ARID) family of DNA binding proteins. The encoded protein forms a histone H3K9Me2 demethylase complex with PHD finger protein 2 and regulates the transcription of target genes involved in adipogenesis and liver development. ARID5B also plays a role in cell growth and differentiation of B-lymphocyte progenitors, and single nucleotide polymorphisms in this gene are associated with acute lymphoblastic leukemia. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARID domain-containing protein 5B; AT rich interactive domain 5B (MRF1-like); AT-rich interactive domain 5B (MRF1-like); AT-rich interactive domain-containing protein 5B; Modulator recognition factor 2; modulator recognition factor 2 (MRF2); MRF-2; MRF1-like protein
Gene Aliases: ARID5B; DESRT; MRF-2; MRF2
UniProt ID: (Human) Q14865
Entrez Gene ID: (Human) 84159
RNA polymerase II regulatory region sequence-specific DNA binding
transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding
DNA binding
transcription coactivator activity
protein binding
histone demethylase activity
transcription regulatory region DNA binding
negative regulation of transcription from RNA polymerase II promoter
kidney development
liver development
transcription, DNA-templated
male gonad development
female gonad development
post-embryonic development
fibroblast migration
histone demethylation
adrenal gland development
multicellular organism growth
fat cell differentiation
negative regulation of transcription, DNA-templated
platelet-derived growth factor receptor signaling pathway
cell development
muscle organ morphogenesis
skeletal system morphogenesis
positive regulation of sequence-specific DNA binding transcription factor activity
palate development
face morphogenesis
adipose tissue development
fat pad development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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