Proteintech

ARIH2 Polyclonal Antibody

ARIH2 Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 9

ARIH2 Antibody (15006-1-AP) in ICC/IF

Immunofluorescent analysis of ( -20°C Ethanol ) fixed HEK-293 cells using 15006-1-AP (ARIH2 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

ARIH2 Antibody in Immunoprecipitation (IP)

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Product Details

15006-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 3 publications 3 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:20-1:200

Immunoprecipitation (IP)

0.5-4.0 µg

View 2 publications 2 publications

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ARIH2 Fusion Protein Ag6507 (140-493 aa encoded by BC000422)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: AVCMQFVRK ENLLSLACQH QFCRSCWEQH CSVLVKDGVG VGVSCMAQDC PLRTPEDFVF PLLPNEELRE KYRRYLFRDY VESHYQLQLC PGADCPMVIR VQEPRARRVQ CNRCNEVFCF KCRQMYHAPT DCATIRKWLT KCADDSETAN YISAHTKDCP KCNICIEKNG GCNHMQCSKC KHDFCWMCLG DWKTHGSEYY ECSRYKENPD IVNQSQQAQA REALKKYLFY FERWENHNKS LQLEAQTYQR IHEKIQERVM NNLGTWIDWQ YLQNAAKLLA KCRYTLQYTY PYAYYMESGP RKKLFEYQQA QLEAEIENLS WKVERADSYD RGDLENQMHI AEQRRRTLLK DFHDT (140-493 aa encoded by BC000422)

Target Information

E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys-63'-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination.

Cell death & disease

Geng S,Peng W,Wang X,Hu X,Liang H,Hou J,Wang F,Zhao G,Lü M,Cui H

Wed Jun 22 00:00:00 UTC 2022

ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination.

Cell death & disease

Geng S,Peng W,Wang X,Hu X,Liang H,Hou J,Wang F,Zhao G,Lü M,Cui H

Wed Jun 22 00:00:00 UTC 2022

ARIH2 regulates the proliferation, DNA damage and chemosensitivity of gastric cancer cells by reducing the stability of p21 via ubiquitination.

Cell death & disease

Geng S,Peng W,Wang X,Hu X,Liang H,Hou J,Wang F,Zhao G,Lü M,Cui H

Wed Jun 22 00:00:00 UTC 2022

The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia.

Oncogene

Wang H,Bei L,Shah CA,Huang W,Platanias LC,Eklund EA

Tue May 01 00:00:00 UTC 2018

The E3 ubiquitin ligase Triad1 influences development of Mll-Ell-induced acute myeloid leukemia.

Oncogene

Wang H,Bei L,Shah CA,Huang W,Platanias LC,Eklund EA

Tue May 01 00:00:00 UTC 2018

ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system.

Nature immunology

Lin AE,Ebert G,Ow Y,Preston SP,Toe JG,Cooney JP,Scott HW,Sasaki M,Saibil SD,Dissanayake D,Kim RH,Wakeham A,You-Ten A,Shahinian A,Duncan G,Silvester J,Ohashi PS,Mak TW,Pellegrini M

Tue Jan 01 00:00:00 UTC 2013

ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system.

Nature immunology

Lin AE,Ebert G,Ow Y,Preston SP,Toe JG,Cooney JP,Scott HW,Sasaki M,Saibil SD,Dissanayake D,Kim RH,Wakeham A,You-Ten A,Shahinian A,Duncan G,Silvester J,Ohashi PS,Mak TW,Pellegrini M

Tue Jan 01 00:00:00 UTC 2013

ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system.

Nature immunology

Lin AE,Ebert G,Ow Y,Preston SP,Toe JG,Cooney JP,Scott HW,Sasaki M,Saibil SD,Dissanayake D,Kim RH,Wakeham A,You-Ten A,Shahinian A,Duncan G,Silvester J,Ohashi PS,Mak TW,Pellegrini M

Tue Jan 01 00:00:00 UTC 2013

ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system.

Nature immunology

Lin AE,Ebert G,Ow Y,Preston SP,Toe JG,Cooney JP,Scott HW,Sasaki M,Saibil SD,Dissanayake D,Kim RH,Wakeham A,You-Ten A,Shahinian A,Duncan G,Silvester J,Ohashi PS,Mak TW,Pellegrini M

Tue Jan 01 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: all-trans retinoic acid inducible RING finger; ARI-2; ariadne 2; ariadne homolog 2; E3 ubiquitin-protein ligase ARIH2; FLJ10938; FLJ33921; OTTHUMP00000210388; protein ariadne-2 homolog; Triad1 protein; UbcM4-interacting protein 48

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Gene Aliases: AI843547; ARI2; ARIH2; HT005; TRIAD1; UIP48

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UniProt ID: (Human) O95376, (Mouse) Q9Z1K6

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Entrez Gene ID: (Human) 10425, (Mouse) 23807, (Rat) 316005

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Function(s)

ubiquitin-protein transferase activity protein binding zinc ion binding ligase activity ubiquitin conjugating enzyme binding ubiquitin protein ligase activity nucleic acid binding UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity ribosomal S6-glutamic acid ligase activity coenzyme F420-0 gamma-glutamyl ligase activity coenzyme F420-2 alpha-glutamyl ligase activity metal ion binding protein-glycine ligase activity protein-glycine ligase activity, initiating protein-glycine ligase activity, elongating tubulin-glycine ligase activity protein-glutamic acid ligase activity tubulin-glutamic acid ligase activity

Process(es)

protein polyubiquitination ubiquitin-dependent protein catabolic process protein ubiquitination involved in ubiquitin-dependent protein catabolic process developmental cell growth protein K63-linked ubiquitination protein K48-linked ubiquitination hematopoietic stem cell proliferation positive regulation of protein targeting to mitochondrion multicellular organism development positive regulation of proteasomal ubiquitin-dependent protein catabolic process

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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ARIH2 Polyclonal Antibody

ARIH2 Antibody (15006-1-AP) in ICC/IF

Product Details

15006-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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