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Proteintech
ARL8A/ARL8B Monoclonal Antibody (2F4C3)
FIGURE: 1 / 3
ARL8A/ARL8B Antibody (68186-1-IG) in WB
Various lysates were subjected to SDS PAGE followed by western blot with 68186-1-Ig (ARL8A/ARL8B antibody) at dilution of 1:20000 incubated at room temperature for 1.5 hours. The membrane was stripped and reblotted with HRP-conjugated GAPDH Monoclonal antibody (HRP-60004) as loading control.
Product Details
68186-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rabbit,
Rat
Host/Isotype
Mouse
/ IgG2a
Class
Monoclonal
Type
Antibody
Clone
2F4C3
Immunogen
Recombinant protein
Conjugate
Form
Liquid
Purification
Protein A
Storage buffer
PBS with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Immunogen sequence: MIALFNKLLD WFKALFWKEE MELTLVGLQY SGKTTFVNVI ASGQFNEDMI PTVGFNMRKI TKGNVTIKLW DIGGQPRFRS MWERYCRGVS AIVYMVDAAD QEKIEASKNE LHNLLDKPQL QGIPVLVLGN KRDLPGALDE KELIEKMNLS AIQDREICCY SISCKEKDNI DITLQWLIQH SKSRRS
Target Information
ARL8A and ARL8B are members of the ADP-ribosylation factor-like (ARL) family of small GTPases, which play important roles in intracellular trafficking and vesicular transport. The structure of ARL8A and ARL8B consists of a conserved GTPase domain that binds to guanine nucleotides (GDP and GTP) and a C-terminal lipid modification site that allows their association with cellular membranes. They share a high degree of sequence similarity, with ARL8B being the closest homolog of ARL8A. Functionally, ARL8A and ARL8B are involved in the regulation of lysosomal positioning and trafficking. They are primarily localized to late endosomes and lysosomes, where they interact with various effector proteins to control the movement of these organelles along microtubules. ARL8A and ARL8B have been implicated in mediating lysosomal fusion events, lysosomal tubulation, and lysosome-related processes such as autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADP-ribosylation factor like GTPase 8A; ADP-ribosylation factor like GTPase 8B; ADP-ribosylation factor-like 10B; ADP-ribosylation factor-like 10C; ADP-ribosylation factor-like 8A; ADP-ribosylation factor-like 8B; ADP-ribosylation factor-like protein 10B; ADP-ribosylation factor-like protein 10C; ADP-ribosylation factor-like protein 8A; ADP-ribosylation factor-like protein 8B; Novel small G protein indispensable for equal chromosome segregation 1; Novel small G protein indispensable for equal chromosome segregation 2; small G protein indispensable for equal chromosome segregation 1; small G protein indispensable for equal chromosome segregation 2
Gene Aliases: 1110033P22Rik; 2610313E07Rik; 3100002J04Rik; ARL10B; ARL10C; ARL8A; ARL8B; GIE1; GIE2; RGD1565940
UniProt ID: (Human) Q96BM9, (Human) Q9NVJ2, (Mouse) Q8VEH3, (Rat) Q66HA6, (Mouse) Q3TXD7
Entrez Gene ID: (Human) 127829, (Human) 55207, (Mouse) 68724, (Rat) 498234, (Rat) 500282, (Mouse) 67166
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