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Proteintech
ARMER Polyclonal Antibody
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Product Details
12988-1-AP
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ARMER Fusion Protein Ag3639 (1-203 aa encoded by BC010281)
Conjugate
Form
Liquid
Concentration
0.28 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: MAEGDNRST NLLAAETASL EEQLQGWGEV MLMADKVLRW ERAWFPPAIM GVVSLVFLII YYLDPSVLSG VSCFVMFLCL ADYLVPILAP RIFGSNKWTT EQQQRFHEIC SNLVKTRRRA VGWWKRLFTL KEEKPKMYFM TMIVSLAAVA WVGQQVHNLL LTYLIVTSLL LLPGLNQHGI ILKYIGMAKR EINKLLKQKE KKNE (1-203 aa encoded by BC010281)
Target Information
Apoptosis is important for normal development and tissue homeostasis. It is mediated by various caspases and ultimately results in the activation of endogenous endonucleases that degrade cellular DNA. Although apoptosis induced by endoplasmic reticulum (ER) stress is thought to be mediated by caspase-12, other caspases such as caspase-9 are also thought to be activated following ER stress. Recently, ARMER, a novel integral ER-membrane protein was shown to protect cells from ER stress-induced apoptosis. Analysis of the caspase proteolytic cascade suggests that ARMER acts by inhibiting caspase-9 activity, although the mechanism for this remains unknown. It should be noted that ARMER is not related to the inhibitor of apoptosis proteins (IAP) family and does not contain any baculoviral IAP repeat (BIR) domains.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ADP-ribosylation factor GTPase 6 interacting protein 1; ADP-ribosylation factor like GTPase 6 interacting protein 1; ADP-ribosylation factor-like 6 interacting protein 1; ADP-ribosylation factor-like protein 6-interacting protein 1; ADP-ribosylation-like factor 6 interacting protein; ADP-ribosylation-like factor 6-interacting protein; aip-1; Apoptotic regulator in the membrane of the endoplasmic reticulum; ARL-6-interacting protein 1; Protein TBX2
Gene Aliases: Aip-1; AIP-6; AIP1; AL022945; ARL6IP; ARL6IP1; ARMER; AU042858; C85138; KIAA0069; mKIAA0069; SPG61
UniProt ID: (Human) Q15041, (Mouse) Q9JKW0
Entrez Gene ID: (Human) 23204, (Mouse) 54208, (Rat) 293551
positive regulation of L-glutamate transport
cotranslational protein targeting to membrane
apoptotic process
negative regulation of apoptotic process
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
endoplasmic reticulum tubular network assembly
endoplasmic reticulum tubular network membrane organization
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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