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Product Details
PA5-30338
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein encompassing a sequence within the center region of human ARNT2. The exact sequence is proprietary.
Conjugate
Form
Liquid
Concentration
0.47 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
0.1M tris glycine, pH 7, with 20% glycerol
Contains
0.01% thimerosal
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2547812
Product Specific Information
Recommended positive controls: Mouse brain.
Predicted reactivity: Mouse (99%), Rat (98%), Zebrafish (88%), Xenopus laevis (91%), Sheep (98%), Bovine (98%).
Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.
Target Information
AhR, ARNT1, ARNT2 and BMAL1 are members of a family of transcription factors that contain a basic helix-loop-helix motif and a common "PAS" motif. The aromatic (aryl) hydrocarbon receptor, AhR, is a ligand dependent transcription factor that interacts with specific DNA sequences termed xenobiotic responsive elements (XREs) to activate several genes including CYP1A1, glutathione S-transferase Ya subunit and DT-diaphorase. The Ah receptor nuclear translocator proteins (Arnt 1 or Arnt 2) are required for ligand-dependent nuclear translocation of the Ah receptor and are also necessary for Ah receptor binding to the XRE element. BMAL1 (Brain and Muscle Arnt-like protein 1), also designated Arnt 3, TIC, JAP3 or MOP-3, has been shown to dimerize with Clock and bind to the promoter region of mPer1, suggesting that this protein plays a role in regulation of circadian oscillation in mammals.
⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ARNT 2; ARNT protein 2; Aryl hydrocarbon receptor nuclear translocator 2; aryl-hydrocarbon receptor nuclear translocator 2; bHLHe1; Class E basic helix-loop-helix protein 1
Gene Aliases: ARNT2; BHLHE1; Hif-2b; KIAA0307; mKIAA0307; WEDAS
UniProt ID: (Human) Q9HBZ2, (Mouse) Q61324
Entrez Gene ID: (Human) 9915, (Mouse) 11864
RNA polymerase II core promoter proximal region sequence-specific DNA binding
transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding
transcription factor activity, sequence-specific DNA binding
aryl hydrocarbon receptor binding
protein heterodimerization activity
DNA binding
signal transducer activity
protein dimerization activity
response to hypoxia
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
signal transduction
central nervous system development
brain development
positive regulation of cell proliferation
response to xenobiotic stimulus
response to toxic substance
negative regulation of apoptotic process
positive regulation of transcription, DNA-templated
positive regulation of transcription from RNA polymerase II promoter
in utero embryonic development
response to estradiol
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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