Proteintech

ARPC2 Polyclonal Antibody

ARPC2 Antibody in Immunocytochemistry (ICC/IF)

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ARPC2 Antibody (15058-1-AP) in ICC/IF

Immunofluorescent analysis of Hela cells, using ARPC2 antibody 15058-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red).

ARPC2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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Product Details

15058-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 5 publications 5 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

View 1 publication 1 publication

Not applicable (N/A)

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ARPC2 Fusion Protein Ag7041 (1-300 aa encoded by BC000590)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.23 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MILLEVNNR IIEETLALKF ENAAAGNKPE AVEVTFADFD GVLYHISNPN GDKTKVMVSI SLKFYKELQA HGADELLKRV YGSFLVNPES GYNVSLLYDL ENLPASKDSI VHQAGMLKRN CFASVFEKYF QFQEEGKEGE NRAVIHYRDD ETMYVESKKD RVTVVFSTVF KDDDDVVIGK VFMQEFKEGR RASHTAPQVL FSHREPPLEL KDTDAAVGDN IGYITFVLFP RHTNASARDN TINLIHTFRD YLHYHIKCSK AYIHTRMRAK TSDFLKVLNR ARPDAEKKEM KTITGKTFSS R (1-300 aa encoded by BC000590)

Target Information

This gene encodes one of seven subunits of the human Arp2/3 protein complex. The Arp2/3 protein complex has been implicated in the control of actin polymerization in cells and has been conserved through evolution. The exact role of the protein encoded by this gene, the p34 subunit, has yet to be determined. Two alternatively spliced variants have been characterized to date. Additional alternatively spliced variants have been described but their full length nature has not been determined.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Localization of Kif1c mRNA to cell protrusions dictates binding partner specificity of the encoded protein.

Genes & development

Norris ML,Mendell JT

Wed Mar 01 00:00:00 UTC 2023

Substrate rigidity dictates colorectal tumorigenic cell stemness and metastasis via CRAD-dependent mechanotransduction.

Cell reports

Chang Y,Zhang J,Huo X,Qu X,Xia C,Huang K,Xie F,Wang N,Wei X,Jia Q

Tue Feb 15 00:00:00 UTC 2022

Feedback-Driven Mechanisms Between Phosphorylated Caveolin-1 and Contractile Actin Assemblies Instruct Persistent Cell Migration.

Frontiers in cell and developmental biology

Shi X,Wen Z,Wang Y,Liu YJ,Shi K,Jiu Y

Sun May 02 00:00:00 UTC 2021

Feedback-Driven Mechanisms Between Phosphorylated Caveolin-1 and Contractile Actin Assemblies Instruct Persistent Cell Migration.

Frontiers in cell and developmental biology

Shi X,Wen Z,Wang Y,Liu YJ,Shi K,Jiu Y

Sun May 02 00:00:00 UTC 2021

WDR63 inhibits Arp2/3-dependent actin polymerization and mediates the function of p53 in suppressing metastasis.

EMBO reports

Zhao K,Wang D,Zhao X,Wang C,Gao Y,Liu K,Wang F,Wu X,Wang X,Sun L,Zang J,Mei Y

Fri Apr 03 00:00:00 UTC 2020

RBM3 upregulates ARPC2 by binding the 3'UTR and contributes to breast cancer progression.

International journal of oncology

Chen P,Yue X,Xiong H,Lu X,Ji Z

Mon Apr 01 00:00:00 UTC 2019

The Proteome of BLOC-1 Genetic Defects Identifies the Arp2/3 Actin Polymerization Complex to Function Downstream of the Schizophrenia Susceptibility Factor Dysbindin at the Synapse.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Gokhale A,Hartwig C,Freeman AH,Das R,Zlatic SA,Vistein R,Burch A,Carrot G,Lewis AF,Nelms S,Dickman DK,Puthenveedu MA,Cox DN,Faundez V

Wed Dec 07 00:00:00 UTC 2016

The Proteome of BLOC-1 Genetic Defects Identifies the Arp2/3 Actin Polymerization Complex to Function Downstream of the Schizophrenia Susceptibility Factor Dysbindin at the Synapse.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Gokhale A,Hartwig C,Freeman AH,Das R,Zlatic SA,Vistein R,Burch A,Carrot G,Lewis AF,Nelms S,Dickman DK,Puthenveedu MA,Cox DN,Faundez V

Wed Dec 07 00:00:00 UTC 2016

α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3.

The Journal of cell biology

Paul NR,Allen JL,Chapman A,Morlan-Mairal M,Zindy E,Jacquemet G,Fernandez del Ama L,Ferizovic N,Green DM,Howe JD,Ehler E,Hurlstone A,Caswell PT

Mon Sep 14 00:00:00 UTC 2015

α5β1 integrin recycling promotes Arp2/3-independent cancer cell invasion via the formin FHOD3.

The Journal of cell biology

Paul NR,Allen JL,Chapman A,Morlan-Mairal M,Zindy E,Jacquemet G,Fernandez del Ama L,Ferizovic N,Green DM,Howe JD,Ehler E,Hurlstone A,Caswell PT

Mon Sep 14 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: actin related protein 2/3 complex subunit 2, 34kDa; actin related protein 2/3 complex, subunit 2, 34kDa; Actin-related protein 2/3 complex subunit 2; actin-related protein 2/3 complex subunit 2 {ECO:0000250|UniProtKB:O15144}; Arp2/3 complex 34 kDa subunit; arp2/3 complex 34 kDa subunit {ECO:0000250|UniProtKB:O15144}; ARP2/3 protein complex subunit 34; arpc2 {ECO:0000250|UniProtKB:O15144}; p34-ARC; p34-ARC {ECO:0000250|UniProtKB:O15144}; testis tissue sperm-binding protein Li 53e

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Gene Aliases: 2210023N03Rik; 34kDa; ARC34; ARPC2; p34-Arc; PNAS-139; PRO2446

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UniProt ID: (Human) O15144, (Mouse) Q9CVB6

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Entrez Gene ID: (Human) 10109, (Rat) 301511, (Mouse) 76709

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Function(s)

structural constituent of cytoskeleton protein binding actin filament binding kinesin binding AP-1 adaptor complex binding Arp2/3 complex binding actin binding

Process(es)

positive regulation of lamellipodium assembly positive regulation of actin filament polymerization Arp2/3 complex-mediated actin nucleation positive regulation of substrate adhesion-dependent cell spreading movement of cell or subcellular component Fc-gamma receptor signaling pathway involved in phagocytosis ephrin receptor signaling pathway regulation of actin filament polymerization

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ARPC2 Polyclonal Antibody

ARPC2 Antibody (15058-1-AP) in ICC/IF

Product Details

15058-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Not applicable (N/A)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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