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Proteintech
ASIC2 Polyclonal Antibody
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Product Details
17851-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ASIC2 Fusion Protein Ag12301 (60-426 aa encoded by BC075043)
Conjugate
Form
Liquid
Concentration
0.27 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: SSERVSYYF SYQHVTKVDE VVAQSLVFPA VTLCNLNGFR FSRLTTNDLY HAGELLALLD VNLQIPDPHL ADPSVLEALR QKANFKHYKP KQFSMLEFLH RVGHDLKDMM LYCKFKGQEC GHQDFTTVFT KYGKCYMFNS GEDGKPLLTT VKGGTGNGLE IMLDIQQDEY LPIWGETEET TFEAGVKVQI HSQSEPPFIQ ELGFGVAPGF QTFVATQEQR LTYLPPPWGE CRSSEMGLDF FPVYSITACR IDCETRYIVE NCNCRMVHMP GDAPFCTPEQ HKECAEPALG LLAEKDSNYC LCRTPCNLTR YNKELSMVKI PSKTSAKYLE KKFNKSEKYI SENILVLDIF FEALNYETIE QKKAYEVA (60-426 aa encoded by BC075043 )
Target Information
ACCN1 encodes a member of the degenerin/epithelial sodium channel (DEG/ENaC) superfamily. The members of this family are amiloride-sensitive sodium channels that contain intracellular N and C termini, 2 hydrophobic transmembrane regions, and a large extracellular loop, which has many cysteine residues with conserved spacing. The member encoded by this protein may play a role in neurotransmission. In addition, a heteromeric association between this member and ACCN3 (variant 1) has been observed to co-assemble into proton-gated channels sensitive to gadolinium.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: acid sensing (proton gated) ion channel 2; acid sensing ion channel 2; acid-sensing (proton-gated) ion channel 2; Acid-sensing ion channel 2; Amiloride-sensitive brain sodium channel; Amiloride-sensitive brain sodium channel 2; Amiloride-sensitive cation channel 1, neuronal; amiloride-sensitive cation channel 1, neuronal (degenerin); Amiloride-sensitive cation channel neuronal 1; ASIC2; BNC1; Brain sodium channel 1; degenerin; Mammalian degenerin homolog; MDEG; neuronal amiloride-sensitive cation channel 1
Gene Aliases: ACCN; ACCN1; ACIC2; ASIC2; ASIC2a; BNAC1; BNaC1a; BNC1; BNC1k; hBNaC1; MDEG; MDEG1; MDEG2
UniProt ID: (Human) Q16515, (Rat) Q62962, (Mouse) Q925H0
Entrez Gene ID: (Human) 40, (Rat) 25364, (Mouse) 11418
regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback
cation transport
sodium ion transport
phototransduction
sensory perception of sound
response to mechanical stimulus
response to acidic pH
regulation of gene expression
regulation of vasoconstriction
regulation of blood coagulation
ion transmembrane transport
regulation of ion transmembrane transport
protein localization to synapse
cellular response to drug
sodium ion transmembrane transport
regulation of membrane potential
negative regulation of apoptotic process
sensory perception of sour taste
detection of mechanical stimulus involved in sensory perception
positive regulation of synapse assembly
cellular response to acidic pH
cation transmembrane transport
positive regulation of cation channel activity
chemical synaptic transmission
central nervous system development
peripheral nervous system development
monovalent inorganic cation transport
transport
ion transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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