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Invitrogen
ASIP Polyclonal Antibody
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Product Details
PA5-102861
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human ASIP(Accession P42127), corresponding to amino acid residues K81-N131.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2852245
Product Specific Information
Antibody detects endogenous levels of total ASIP.
Target Information
In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: agouti signaling protein, nonagouti homolog; Agouti switch protein; Agouti-signaling protein; ASP; nonagouti homolog
Gene Aliases: AGSW; AGTI; AGTIL; ASIP; ASP; SHEP9
UniProt ID: (Human) P42127
Entrez Gene ID: (Human) 434
generation of precursor metabolites and energy
signal transduction
cell-cell signaling
adult feeding behavior
hormone-mediated signaling pathway
melanosome transport
melanosome organization
regulation of molecular function, epigenetic
melanin biosynthetic process
positive regulation of melanin biosynthetic process
genetic imprinting
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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