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Proteintech
ASL Monoclonal Antibody (1G9H3)
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Product Details
67692-1-IG
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Pig,
Rat
Host/Isotype
Mouse
/ IgG2b
Class
Monoclonal
Type
Antibody
Clone
1G9H3
Immunogen
ASL Fusion Protein Ag30517
Conjugate
Form
Liquid
Concentration
500 µg/mL
Purification
Protein A
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
Aliquoting is unnecessary for -20°C storage.
Target Information
ASL encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: argininosuccinase; Argininosuccinate lyase; Arginosuccinase; ASAL
Gene Aliases: 2510006M18Rik; ASAL; ASL
UniProt ID: (Human) P04424, (Mouse) Q91YI0, (Rat) P20673
Entrez Gene ID: (Human) 435, (Mouse) 109900, (Rat) 59085
urea cycle
argininosuccinate metabolic process
liver development
internal protein amino acid acetylation
cellular amino acid metabolic process
arginine biosynthetic process
locomotory behavior
cellular amino acid biosynthetic process
post-embryonic development
ammonia assimilation cycle
arginine biosynthetic process via ornithine
arginine catabolic process
protein tetramerization
kidney development
midgut development
aging
response to nutrient
response to toxic substance
response to zinc ion
response to amine
response to lipopolysaccharide
response to drug
response to peptide hormone
response to steroid hormone
response to growth hormone
diaphragm development
cellular response to ammonium ion
cellular response to cAMP
cellular response to interferon-gamma
cellular response to tumor necrosis factor
cellular response to glucagon stimulus
cellular response to glucocorticoid stimulus
cellular response to hypoxia
cellular response to dexamethasone stimulus
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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