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Product Details
H00000444-M09
Product Specifications
Species Reactivity
Human
Host/Isotype
Mouse
/ IgG2a, kappa
Class
Monoclonal
Type
Antibody
Clone
3G5
Immunogen
ASPH (NP_115857, 161 a.a. approximately 270 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Form
Liquid
Concentration
See Label
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
Sequence of this protein is as follows: PTGEPQQEDD EFLMATDVDD RFETLEPEVS HEETEHSYHV EETVSQDCNQ DMEEMMSEQE NPDSSEPVVE DERLHHDTDD VTYQVYEEQA VYEPLENEGI EITEVTAPPE
Target Information
ASPH is thought to play an important role in calcium homeostasis. Alternative splicing of this gene results in five transcript variants which vary in protein translation, the coding of catalytic domains, and tissue expression. Variation among these transcripts impacts their functions which involve roles in the calcium storage and release process in the endoplasmic and sarcoplasmic reticulum as well as hydroxylation of aspartic acid and asparagine in epidermal growth factor-like domains of various proteins. This gene is thought to play an important role in calcium homeostasis. Alternative splicing of this gene results in five transcript variants which vary in protein translation, the coding of catalytic domains, and tissue expression. Variation among these transcripts impacts their functions which involve roles in the calcium storage and release process in the endoplasmic and sarcoplasmic reticulum as well as hydroxylation of aspartic acid and asparagine in epidermal growth factor-like domains of various proteins.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: A beta H-J-J; ASP beta-hydroxylase; Aspartate beta-hydroxylase; Aspartyl/asparaginyl beta-hydroxylase; aspartyl/asparaginyl-beta-hydroxylase; cardiac junctin; humbug; junctate; Peptide-aspartate beta-dioxygenase
Gene Aliases: AAH; ASPH; BAH; CASQ2BP1; FDLAB; HAAH; JCTN; junctin
UniProt ID: (Human) Q12797
Entrez Gene ID: (Human) 444
muscle contraction
pattern specification process
negative regulation of cell proliferation
regulation of protein stability
ion transmembrane transport
limb morphogenesis
peptidyl-aspartic acid hydroxylation
positive regulation of proteolysis
oxidation-reduction process
palate development
face morphogenesis
activation of cysteine-type endopeptidase activity
regulation of protein depolymerization
regulation of cardiac conduction
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