OriGene

ATF 4 (ATF4) Monoclonal Antibody (OTI8F5), TrueMAB™

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

CF812805

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Mouse / IgG1

Class

Monoclonal

Type

Antibody

Clone

OTI8F5

Immunogen

Full length human recombinant protein of human Atf4 (NP_001666) produced in E.coli.
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

See Label

Purification

Protein A/G

Storage buffer

PBS, pH 7.3, with 8% trehalose

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

This gene encodes a transcription factor that was originally identified as a widely expressed mammalian DNA binding protein that could bind a tax-responsive enhancer element in the LTR of HTLV-1. The encoded protein was also isolated and characterized as the cAMP-response element binding protein 2 (CREB-2). The protein encoded by this gene belongs to a family of DNA-binding proteins that includes the AP-1 family of transcription factors, cAMP-response element binding proteins (CREBs) and CREB-like proteins. These transcription factors share a leucine zipper region that is involved in protein-protein interactions, located C-terminal to a stretch of basic amino acids that functions as a DNA binding domain. Two alternative transcripts encoding the same protein have been described. Two pseudogenes are located on the X chromsome at q28 in a region containing a large inverted duplication.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: Activating transcription factor 4; activating transcription factor 4 (tax-responsive enhancer element B67); activating transcription factor ATF-4; ATF 4; ATF4 protein; atf4 {ECO:0000312|RGD:621863}; C/ATF; C/EBP-related ATF; cAMP response element-binding protein 2; cAMP-dependent transcription factor ATF-4; cAMP-responsive element-binding protein 2; CREB 2; CREB-2; Cyclic AMP-dependent transcription factor ATF-4; Cyclic AMP-responsive element-binding protein 2; DNA-binding protein TAXREB67; OTTHUMP00000199130; rATF-4; tax-re; tax-responsive enhancer element B67; Tax-responsive enhancer element-binding protein 67; tax-responsive enhancer element-binding protein 67 homolog; TaxREB67; taxREB67 homolog

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Gene Aliases: Atf-4; ATF4; C/ATF; CREB-2; CREB2; TAXREB67; TXREB

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UniProt ID: (Human) P18848, (Rat) Q9ES19, (Mouse) Q06507

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Entrez Gene ID: (Human) 468, (Rat) 79255, (Mouse) 11911

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Function(s)
RNA polymerase II regulatory region sequence-specific DNA binding RNA polymerase II core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity, sequence-specific DNA binding core promoter sequence-specific DNA binding transcription factor activity, RNA polymerase II transcription factor binding transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding RNA polymerase II transcription factor binding DNA binding transcription factor activity, sequence-specific DNA binding protein binding protein C-terminus binding leucine zipper domain binding sequence-specific DNA binding transcription regulatory region DNA binding protein heterodimerization activity transcription factor binding
Process(es)
gluconeogenesis transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter transcription from RNA polymerase II promoter gamma-aminobutyric acid signaling pathway positive regulation of vascular endothelial growth factor production circadian regulation of gene expression response to endoplasmic reticulum stress positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress cellular response to glucose starvation negative regulation of potassium ion transport positive regulation of neuron apoptotic process positive regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase I promoter positive regulation of transcription from RNA polymerase II promoter intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress negative regulation of oxidative stress-induced neuron death positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress positive regulation of gene expression cellular response to amino acid starvation PERK-mediated unfolded protein response rhythmic process cellular amino acid metabolic process negative regulation of translational initiation in response to stress cellular response to UV positive regulation of transcription from RNA polymerase II promoter in response to stress mRNA transcription from RNA polymerase II promoter positive regulation of apoptotic process positive regulation of transcription from RNA polymerase II promoter in response to arsenic-containing substance response to manganese-induced endoplasmic reticulum stress
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