Proteintech

ATF6B Polyclonal Antibody

ATF6B Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 6

ATF6B Antibody (15794-1-AP) in ICC/IF

Immunofluorescent analysis of HepG2 cells, using ATF6B antibody 15794-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IGG (red). Blue pseudocolor = DAPI (fluorescent DNA dye).

ATF6B Antibody in Immunohistochemistry (Paraffin) (IHC (P))

ATF6B Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

15794-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:1,000-1:4,000

View 14 publications 14 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

1:10-1:100

View 1 publication 1 publication

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ATF6B Fusion Protein Ag8502 (1-318 aa encoded by BC008394)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.26 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody could recognize ATF6 beta (110 kDa) and its cleaved forms(60,80 kDa )

Immunogen sequence: MAELMLLSE IADPTRFFTD NLLSPEDWGL QNSTLYSGLD EVAEEQTQLF RCPEQDVPFD GSSLDVGMDV SPSEPPWELL PIFPDLQVKS EPSSPCSSSS LSSESSRLST EPSSEALGVG EVLHVKTESL APPLCLLGDD PTSSFETVQI NVIPTSDDSS DVQTKIEPVS PCSSVNSEAS LLSADSSSQA FIGEEVLEVK TESLSPSGCL LWDVPAPSLG AVQISMGPSL DGSSGKALPT RKPPLQPKPV VLTTVPMPSR AVSPSTTVLL QSLVQPPPGT EEGEKGRAWW LTPVIPALWE AEAGESPEVR SLRPAWPTW (1-318 aa encoded by BC008394 )

Target Information

ATF6 beta(CREBL1) is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. ATF6 beta is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene. The protein encoded by this gene bears sequence similarity with the Creb/ATF subfamily of the bZip superfamily of transcription factors. It localizes to both the cytoplasm and the nucleus. The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

AGK2 pre-treatment protects against thioacetamide-induced acute liver failure via regulating the MFN2-PERK axis and ferroptosis signaling pathway.

Hepatobiliary & pancreatic diseases international : HBPD INT

Zhang QQ,Chen Q,Cao P,Shi CX,Zhang LY,Wang LW,Gong ZJ

Thu Feb 01 00:00:00 UTC 2024

The cytotoxic activity of carfilzomib together with nelfinavir is superior to the bortezomib/nelfinavir combination in non-small cell lung carcinoma.

Scientific reports

Besse L,Kraus M,Besse A,Driessen C,Tarantino I

Fri Mar 17 00:00:00 UTC 2023

miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress.

Frontiers in cell and developmental biology

Hayashi C,Fukuda T,Kawakami K,Toyoda M,Nakao Y,Watanabe Y,Shinjo T,Sano T,Iwashita M,Yotsumoto K,Shida M,Taketomi T,Sanui T,Uchiumi T,Kanematsu T,Nishimura F

Thu Dec 22 00:00:00 UTC 2022

miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress.

Frontiers in cell and developmental biology

Hayashi C,Fukuda T,Kawakami K,Toyoda M,Nakao Y,Watanabe Y,Shinjo T,Sano T,Iwashita M,Yotsumoto K,Shida M,Taketomi T,Sanui T,Uchiumi T,Kanematsu T,Nishimura F

Thu Dec 22 00:00:00 UTC 2022

miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress.

Frontiers in cell and developmental biology

Hayashi C,Fukuda T,Kawakami K,Toyoda M,Nakao Y,Watanabe Y,Shinjo T,Sano T,Iwashita M,Yotsumoto K,Shida M,Taketomi T,Sanui T,Uchiumi T,Kanematsu T,Nishimura F

Thu Dec 22 00:00:00 UTC 2022

miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress.

Frontiers in cell and developmental biology

Hayashi C,Fukuda T,Kawakami K,Toyoda M,Nakao Y,Watanabe Y,Shinjo T,Sano T,Iwashita M,Yotsumoto K,Shida M,Taketomi T,Sanui T,Uchiumi T,Kanematsu T,Nishimura F

Thu Dec 22 00:00:00 UTC 2022

miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress.

Frontiers in cell and developmental biology

Hayashi C,Fukuda T,Kawakami K,Toyoda M,Nakao Y,Watanabe Y,Shinjo T,Sano T,Iwashita M,Yotsumoto K,Shida M,Taketomi T,Sanui T,Uchiumi T,Kanematsu T,Nishimura F

Thu Dec 22 00:00:00 UTC 2022

miR-1260b inhibits periodontal bone loss by targeting ATF6β mediated regulation of ER stress.

Frontiers in cell and developmental biology

Hayashi C,Fukuda T,Kawakami K,Toyoda M,Nakao Y,Watanabe Y,Shinjo T,Sano T,Iwashita M,Yotsumoto K,Shida M,Taketomi T,Sanui T,Uchiumi T,Kanematsu T,Nishimura F

Thu Dec 22 00:00:00 UTC 2022

Methamphetamine mediates apoptosis of vascular smooth muscle cells via the chop-related endoplasmic reticulum stress pathway.

Toxicology letters

Tan X,Cai D,Chen N,Du S,Qiao D,Yue X,Wang T,Li J,Xie W,Wang H

Sun Oct 10 00:00:00 UTC 2021

Mfn2 Regulates High Glucose-Induced MAMs Dysfunction and Apoptosis in Podocytes via PERK Pathway.

Frontiers in cell and developmental biology

Cao Y,Chen Z,Hu J,Feng J,Zhu Z,Fan Y,Lin Q,Ding G

Fri Jan 07 00:00:00 UTC 2022

Proteomic Analysis of Marinesco-Sjogren Syndrome Fibroblasts Indicates Pro-Survival Metabolic Adaptation to SIL1 Loss.

International journal of molecular sciences

Potenza F,Cufaro MC,Di Biase L,Panella V,Di Campli A,Ruggieri AG,Dufrusine B,Restelli E,Pietrangelo L,Protasi F,Pieragostino D,De Laurenzi V,Federici L,Chiesa R,Sallese M

Thu Nov 18 00:00:00 UTC 2021

Involvement of kisspeptin in androgen-induced hypothalamic endoplasmic reticulum stress and its rescuing effect in PCOS rats.

Biochimica et biophysica acta. Molecular basis of disease

Yuan C,Huang WQ,Guo JH,Liu XY,Yang JZ,Chen JJ,Wu Y,Ruan YC,Liu JY,Cui YG,Diao FY,Chan HC

Wed Dec 01 00:00:00 UTC 2021

Neuroprotective mechanism of L-cysteine after subarachnoid hemorrhage.

Neural regeneration research

Xiong Y,Xin DQ,Hu Q,Wang LX,Qiu J,Yuan HT,Chu XL,Liu DX,Li G,Wang Z

Thu Oct 01 00:00:00 UTC 2020

Correction to: Protective effects of dioscin against alcohol‑induced liver injury.

Archives of toxicology

Xu T,Zheng L,Xu L,Yin L,Qi Y,Xu Y,Han X,Peng J

Sun Sep 01 00:00:00 UTC 2019

Geniposide Alleviates Isoproterenol-Induced Cardiac Fibrosis Partially via SIRT1 Activation in vivo and in vitro.

Frontiers in pharmacology

Li N,Zhou H,Ma ZG,Zhu JX,Liu C,Song P,Kong CY,Wu HM,Deng W,Tang QZ

Wed Sep 30 00:00:00 UTC 2020

Geniposide Alleviates Isoproterenol-Induced Cardiac Fibrosis Partially via SIRT1 Activation in vivo and in vitro.

Frontiers in pharmacology

Li N,Zhou H,Ma ZG,Zhu JX,Liu C,Song P,Kong CY,Wu HM,Deng W,Tang QZ

Wed Sep 30 00:00:00 UTC 2020

Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive Disorders.

Journal of neuropathology and experimental neurology

Jensen BK,Monnerie H,Mannell MV,Gannon PJ,Espinoza CA,Erickson MA,Bruce-Keller AJ,Gelman BB,Briand LA,Pierce RC,Jordan-Sciutto KL,Grinspan JB

Sun Nov 01 00:00:00 UTC 2015

Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive Disorders.

Journal of neuropathology and experimental neurology

Jensen BK,Monnerie H,Mannell MV,Gannon PJ,Espinoza CA,Erickson MA,Bruce-Keller AJ,Gelman BB,Briand LA,Pierce RC,Jordan-Sciutto KL,Grinspan JB

Sun Nov 01 00:00:00 UTC 2015

Protective effects of dioscin against alcohol-induced liver injury.

Archives of toxicology

Xu T,Zheng L,Xu L,Yin L,Qi Y,Xu Y,Han X,Peng J

Sat Mar 01 00:00:00 UTC 2014

Protective effects of dioscin against alcohol-induced liver injury.

Archives of toxicology

Xu T,Zheng L,Xu L,Yin L,Qi Y,Xu Y,Han X,Peng J

Sat Mar 01 00:00:00 UTC 2014

Protective effects of dioscin against alcohol-induced liver injury.

Archives of toxicology

Xu T,Zheng L,Xu L,Yin L,Qi Y,Xu Y,Han X,Peng J

Sat Mar 01 00:00:00 UTC 2014

Evaluation of the hepatotoxic risk caused by lead acetate via skin exposure using a proteomic approach.

Proteomics

Fang JY,Wang PW,Huang CH,Hung YY,Pan TL

Sat Nov 01 00:00:00 UTC 2014

Evaluation of the hepatotoxic risk caused by lead acetate via skin exposure using a proteomic approach.

Proteomics

Fang JY,Wang PW,Huang CH,Hung YY,Pan TL

Sat Nov 01 00:00:00 UTC 2014

Sinulariolide induced hepatocellular carcinoma apoptosis through activation of mitochondrial-related apoptotic and PERK/eIF2α/ATF4/CHOP pathway.

Molecules (Basel, Switzerland)

Chen YJ,Su JH,Tsao CY,Hung CT,Chao HH,Lin JJ,Liao MH,Yang ZY,Huang HH,Tsai FJ,Weng SH,Wu YJ

Thu Aug 22 00:00:00 UTC 2013

Sinulariolide induced hepatocellular carcinoma apoptosis through activation of mitochondrial-related apoptotic and PERK/eIF2α/ATF4/CHOP pathway.

Molecules (Basel, Switzerland)

Chen YJ,Su JH,Tsao CY,Hung CT,Chao HH,Lin JJ,Liao MH,Yang ZY,Huang HH,Tsai FJ,Weng SH,Wu YJ

Thu Aug 22 00:00:00 UTC 2013

Bioinformatics

Protein Aliases: Activating transcription factor 6 beta; ATF6-beta; cAMP response element binding protein-related protein; cAMP response element-binding protein-related protein; cAMP responsive element binding protein-like 1; cAMP-dependent transcription factor ATF-6 beta; cAMP-responsive element-binding protein-like 1; Creb-related protein; Creb-rp; Cyclic AMP-dependent transcription factor ATF-6 beta; FLJ10066; Protein G13

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Gene Aliases: AA617266; ATF6B; ATF6beta; CREB-RP; CREBL1; G13

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UniProt ID: (Human) Q99941

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Entrez Gene ID: (Human) 1388, (Mouse) 12915, (Rat) 406169

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Function(s)

transcription factor activity, sequence-specific DNA binding protein binding cAMP response element binding sequence-specific DNA binding transcription regulatory region DNA binding DNA binding

Process(es)

transcription, DNA-templated regulation of transcription, DNA-templated regulation of transcription from RNA polymerase II promoter response to unfolded protein endoplasmic reticulum unfolded protein response positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress signal transduction ATF6-mediated unfolded protein response

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ATF6B Polyclonal Antibody

ATF6B Antibody (15794-1-AP) in ICC/IF

Product Details

15794-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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