Proteintech

ATIC Polyclonal Antibody

ATIC Antibody in Immunocytochemistry (ICC/IF)

FIGURE: 1 / 4

ATIC Antibody (10726-1-AP) in ICC/IF

Immunofluorescent analysis of HeLa cells using 10726-1-AP (ATIC antibody) at dilution of 1:25 and Alexa Fluor 594-conjugated AffiniPure Goat Anti-Rabbit IGG (H+L).

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Product Details

10726-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:200-1:1,000

View 4 publications 4 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunocytochemistry (ICC/IF)

1:10-1:100

Product Specifications

Species Reactivity

Human

Published species

Human

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ATIC Fusion Protein Ag1052 (291-592 aa encoded by BC008879)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.13 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: DLYKTLTPI SAAYARARGA DRMSSFGDFV ALSDVCDVPT AKIISREVSD GIIAPGYEEE ALTILSKKKN GNYCVLQMDQ SYKPDENEVR TLFGLHLSQK RNNGVVDKSL FSNVVTKNKD LPESALRDLI VATIAVKYTQ SNSVCYAKNG QVIGIGAGQQ SRIHCTRLAG DKANYWWLRH HPQVLSMKFK TGVKRAEISN AIDQYVTGTI GEDEDLIKWK ALFEEVPELL TEAEKKEWVE KLTEVSISSD AFFPFRDNVD RAKRSGVAYI AAPSGSAADK VVIEACDELG IILAHTNLRL FHH (291-592 aa encoded by BC008879)

Target Information

ATIC is a 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase which helps catalyze the penultimate and final steps of the de novo purine biosynthetic pathway. The human ATIC cDNA encodes a deduced 591-amino acid protein that is 81% identical to the chicken sequence.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Psychosocial and behavioral problems of children and adolescents in the early stage of reopening schools after the COVID-19 pandemic: a national cross-sectional study in China.

Translational psychiatry

Wang L,Zhang Y,Chen L,Wang J,Jia F,Li F,Froehlich TE,Hou Y,Hao Y,Shi Y,Deng H,Zhang J,Huang L,Xie X,Fang S,Xu L,Xu Q,Guan H,Wang W,Shen J,Qian Y,Wang X,Shan L,Tan C,Yu Y,Wang X,Chen F,Zhang L,Li X,Shi X,Ke X,Li T

Thu Jun 03 00:00:00 UTC 2021

Psychosocial and behavioral problems of children and adolescents in the early stage of reopening schools after the COVID-19 pandemic: a national cross-sectional study in China.

Translational psychiatry

Thu Jun 03 00:00:00 UTC 2021

Melatonin modulates metabolic remodeling in HNSCC by suppressing MTHFD1L-formate axis.

Journal of pineal research

Cui L,Zhao X,Jin Z,Wang H,Yang SF,Hu S

Wed Dec 01 00:00:00 UTC 2021

ATIC inhibits autophagy in hepatocellular cancer through the AKT/FOXO3 pathway and serves as a prognostic signature for modeling patient survival.

International journal of biological sciences

Zhang H,Xia P,Liu J,Chen Z,Ma W,Yuan Y

Mon Dec 20 00:00:00 UTC 2021

Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling.

Cell communication and signaling : CCS

Li M,Jin C,Xu M,Zhou L,Li D,Yin Y

Sat Dec 16 00:00:00 UTC 2017

Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling.

Cell communication and signaling : CCS

Li M,Jin C,Xu M,Zhou L,Li D,Yin Y

Sat Dec 16 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleotide transformylase/inosinicase; AICAR formyltransferase/IMP cyclohydrolase bifunctional enzyme; AICAR transformylase/inosine monophosphate cyclohydrolase; AICARFT/IMPCHASE; ATIC; Bifunctional purine biosynthesis protein ATIC; epididymis secretory sperm binding protein Li 70p; phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase

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Gene Aliases: AICAR; AICARFT; ATIC; HEL-S-70p; IMPCHASE; OK/SW-cl.86; PURH

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UniProt ID: (Human) P31939

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Entrez Gene ID: (Human) 471

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Function(s)

IMP cyclohydrolase activity phosphoribosylaminoimidazolecarboxamide formyltransferase activity protein homodimerization activity cadherin binding involved in cell-cell adhesion

Process(es)

brainstem development nucleobase-containing compound metabolic process 'de novo' IMP biosynthetic process nucleoside metabolic process purine ribonucleoside monophosphate biosynthetic process response to inorganic substance cerebellum development cerebral cortex development organ regeneration dihydrofolate metabolic process tetrahydrofolate biosynthetic process cell-cell adhesion

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ATIC Polyclonal Antibody

ATIC Antibody (10726-1-AP) in ICC/IF

Product Details

10726-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunocytochemistry (ICC/IF)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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