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Proteintech
ATN1 Polyclonal Antibody
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Product Details
19243-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ATN1 Fusion Protein Ag5835 (842-1191 aa encoded by BC051795)
Conjugate
Form
Liquid
Concentration
0.23 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: LAQEGRAPV ECPSLGPVPH RPPFEPGSAV ATVPPYLGPD TPALRTLSEY ARPHVMSPGN RNHPFYVPLG AVDPGLLGYN VPALYSSDPA AREREREARE RDLRDRLKPG FEVKPSELEP LHGVPGPGLD PFPRHGGLAL QPGPPGLHPF PFHPSLGPLE RERLALAAGP ALRPDMSYAE RLAAERQHAE RVAALGNDPL ARLQMLNVTP HHHQHSHIHS HLHLHQQDAI HAASASVHPL IDPLASGSHL TRIPYPAGTL PNPLLPHPLH ENEVLRHQLF AAPYRDLPAS LSAPMSAAHQ LQAMHAQSAE LQRLALEQQQ WLHAHHPLHS VPLPAQEDYY SHLKKESDKP L (842-1191 aa encoded by BC051795)
Target Information
Dentatorubral pallidoluysian atrophy (DRPLA) is a rare neurodegenerative disorder characterized by cerebellar ataxia, myoclonic epilepsy, choreoathetosis, and dementia. The disorder is related to the expansion from 7-35 copies to 49-93 copies of a trinucleotide repeat (CAG/CAA) within this gene. The encoded protein includes a serine repeat and a region of alternating acidic and basic amino acids, as well as the variable glutamine repeat. Alternative splicing results in two transcripts variants that encode the same protein.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Atrophin-1; Atrophin1; dentatorubral pallidoluysian atrophy; Dentatorubral-pallidoluysian atrophy protein; Dentatorubral-pallidoluysian atrophy protein homolog
Gene Aliases: ATN1; Atr1; atrophin-1; B37; D12S755E; DRPLA; HRS; NOD
UniProt ID: (Human) P54259, (Mouse) O35126
Entrez Gene ID: (Human) 1822, (Mouse) 13498
negative regulation of transcription from RNA polymerase II promoter
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
toxin metabolic process
cell migration
maintenance of cell polarity
positive regulation of transcription from RNA polymerase II promoter
neuron apoptotic process
negative regulation of nucleic acid-templated transcription
central nervous system development
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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