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Invitrogen
ATOH1 Recombinant Rabbit Monoclonal Antibody (JE60-25)
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ATOH1 Antibody (MA5-44829) in WB
Western blot analysis of MATH1 in Rat brain tissue lysates. Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. Samples were incubated in MATH1 Monoclonal antibody (Product # MA5-44829) using a dilution of 1:1,000 in 5% NFDM/TBST at room temperature for 2 hours followed by Goat Anti-Rabbit IgG - HRP secondary antibody at a dilution of 1:200,000 for 1 hour at room temperature.
Product Details
MA5-44829
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
JE60-25
Immunogen
Synthetic peptide within human MATH1 aa 1-50/354.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Protein A
Storage buffer
TBS, pH 7.4, with 0.05% BSA, 40% glycerol
Contains
0.05% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2931286
Target Information
The Drosophila atonal gene produces a protein with basic helix loop helix (bHLH) domains that plays an essential role in the development of the Drosophila nervous system. Mammalian atonal homolog 1 (MATH-1) is a helix-loop-helix (HLH) transcription factor that is structurally homologous to the product of the Drosophila proneural gene atonal. MATH-1, so known as Atoh1, Ath1 or HATH-1, is a 351 amino acid protein with an atonal-related basic HLH domain. In mice, expression of MATH-1 takes place by embryonic day 9. 5 and initially localizes to the cranial ganglions and the dorsal part of the central nervous system. Prominent expression of MATH-1 is in the dorsal part of the central nervous system but becomes restricted to the external granular layer of the cerebellum by day 18 and is undetectable in the adult nervous system. It is suggested that MATH-1 may play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Atonal bHLH transcription factor 1; H MATH-1; Helix-loop-helix protein mATH-1; mATH1; Protein atonal homolog 1; Transcription factor Atoh1
Gene Aliases: Ath1; Atoh1; bHLHa14; Hath1; MATH-1; Math1; RGD1565171
UniProt ID: (Mouse) P48985
Entrez Gene ID: (Mouse) 11921, (Rat) 500156
neuron migration
transcription, DNA-templated
regulation of transcription, DNA-templated
transcription from RNA polymerase II promoter
Notch signaling pathway
multicellular organism development
nervous system development
axon guidance
brain development
cerebral cortex development
cell differentiation
neuron differentiation
inner ear morphogenesis
auditory receptor cell differentiation
auditory receptor cell fate specification
auditory receptor cell fate determination
negative regulation of apoptotic process
positive regulation of auditory receptor cell differentiation
regulation of neuron differentiation
positive regulation of neuron differentiation
positive regulation of transcription from RNA polymerase II promoter
inner ear development
positive regulation of inner ear receptor cell differentiation
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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