Product References
The mitochondrial fusion protein OPA1 is dispensable in the liver and its absence induces mitohormesis to protect liver from drug-induced injury.
Nature communications
Lee H,Lee TJ,Galloway CA,Zhi W,Xiao W,de Mesy Bentley KL,Sharma A,Teng Y,Sesaki H,Yoon Y
A-21351 was used in Western Blot to demonstrate that OPA1 is dispensable in the liver, and that the mitohormesis induced by OPA1 LKO prevents liver injury and contributes to liver resiliency.
Mon Oct 23 00:00:00 UTC 2023
The Combination of Δ9-Tetrahydrocannabinol and Cannabidiol Suppresses Mitochondrial Respiration of Human Glioblastoma Cells via Downregulation of Specific Respiratory Chain Proteins.
Cancers
Rupprecht A,Theisen U,Wendt F,Frank M,Hinz B
A-21351 was used in Western Blotting to describe a previously unknown mitochondria-targeting mechanism behind the toxic effect of THC and CBD on glioblastoma cells that should be considered in future cancer therapy, especially in combination strategies with other chemotherapeutics.
Mon Jun 27 00:00:00 UTC 2022
Dynamic full-field optical coherence tomography allows live imaging of retinal pigment epithelium stress model.
Communications biology
Groux K,Verschueren A,Nanteau C,Clémençon M,Fink M,Sahel JA,Boccara C,Paques M,Reichman S,Grieve K
A-21351 was used in Immunocytochemistry-immunoflourescence to show that D-FFOCT appears to be an innovative method to follow degenerative disease evolution and could be an appreciated method in the future for live patient diagnostics and to direct treatment choice.
Fri Jun 10 00:00:00 UTC 2022
Characterization of mitochondrial health from human peripheral blood mononuclear cells to cerebral organoids derived from induced pluripotent stem cells.
Scientific reports
Duong A,Evstratova A,Sivitilli A,Hernandez JJ,Gosio J,Wahedi A,Sondheimer N,Wrana JL,Beaulieu JM,Attisano L,Andreazza AC
A-21351 was used in Immunocytochemistry to show preserved mitochondrial genetics, function and treatment responses across PBMCs to iPSCs to COs, and measurable neuronal activity in the COs.
Thu Feb 25 00:00:00 UTC 2021
Characterization of mitochondrial health from human peripheral blood mononuclear cells to cerebral organoids derived from induced pluripotent stem cells.
Scientific reports
Duong A,Evstratova A,Sivitilli A,Hernandez JJ,Gosio J,Wahedi A,Sondheimer N,Wrana JL,Beaulieu JM,Attisano L,Andreazza AC
A-21351 was used in Immunocytochemistry to show preserved mitochondrial genetics, function and treatment responses across PBMCs to iPSCs to COs, and measurable neuronal activity in the COs.
Thu Feb 25 00:00:00 UTC 2021
Dissecting the concordant and disparate roles of NDUFAF3 and NDUFAF4 in mitochondrial complex I biogenesis.
iScience
Murari A,Rhooms SK,Garcia C,Liu T,Li H,Mishra B,Deshong C,Owusu-Ansah E
A-21351 was used in Western Blot to report that when either of the CIAFs - NDUFAF3 or NDUFAF4 - is disrupted, biogenesis of the Q-, N-, and PP-b-modules of CI is impaired.
Fri Aug 20 00:00:00 UTC 2021
Chalcone suppresses tumor growth through NOX4-IRE1α sulfonation-RIDD-miR-23b axis.
Redox biology
Kim HK,Lee HY,Riaz TA,Bhattarai KR,Chaudhary M,Ahn JH,Jeong J,Kim HR,Chae HJ
A-21351 was used in Western Blotting to demonstrate that chalcone triggers endoplasmic reticulum (ER) stress-induced apoptosis through sulfonation of IRE1α by ER-localized NADPH oxidase 4 (NOX4).
Thu Apr 01 00:00:00 UTC 2021
Argonaute binding within 3'-untranslated regions poorly predicts gene repression.
Nucleic acids research
Chu Y,Kilikevicius A,Liu J,Johnson KC,Yokota S,Corey DR
A-21351 was used in Western Blotting to identify potential microRNA (miRNA) binding sites.
Mon Jul 27 00:00:00 UTC 2020
An antibody toolbox to track complex I assembly defines AIF's mitochondrial function.
The Journal of cell biology
Murari A,Rhooms SK,Goparaju NS,Villanueva M,Owusu-Ansah E
A-21351 was used in Western Blotting to characterize the mechanism of apoptosis-inducing factor (AIF) regulating complex I biogenesis by tracking the AI profile observed when AIF expression is impaired.
Mon Oct 05 00:00:00 UTC 2020
An antibody toolbox to track complex I assembly defines AIF's mitochondrial function.
The Journal of cell biology
Murari A,Rhooms SK,Goparaju NS,Villanueva M,Owusu-Ansah E
A-21351 was used in Western Blotting to characterize the mechanism of apoptosis-inducing factor (AIF) regulating complex I biogenesis by tracking the AI profile observed when AIF expression is impaired.
Mon Oct 05 00:00:00 UTC 2020
Inner mitochondrial membrane protein MPV17 mutant mice display increased myocardial injury after ischemia/reperfusion.
American journal of translational research
Madungwe NB,Feng Y,Imam Aliagan A,Tombo N,Kaya F,Bopassa JC
A-21351 was used in Immunoprecipitation, Western Blot to investigate the role and mechanism of action of MPV17 in cardiac ischemia/reperfusion injury.
Fri May 07 00:00:00 UTC 2021
Inner mitochondrial membrane protein MPV17 mutant mice display increased myocardial injury after ischemia/reperfusion.
American journal of translational research
Madungwe NB,Feng Y,Imam Aliagan A,Tombo N,Kaya F,Bopassa JC
A-21351 was used in Immunoprecipitation, Western Blot to investigate the role and mechanism of action of MPV17 in cardiac ischemia/reperfusion injury.
Fri May 07 00:00:00 UTC 2021
Mitophagy in the Retinal Pigment Epithelium of Dry Age-Related Macular Degeneration Investigated in the NFE2L2/PGC-1α-/- Mouse Model.
International journal of molecular sciences
Sridevi Gurubaran I,Viiri J,Koskela A,Hyttinen JMT,Paterno JJ,Kis G,Antal M,Urtti A,Kauppinen A,Felszeghy S,Kaarniranta K
Published figure using ATP Synthase beta monoclonal antibody (Product # A-21351) in Immunocytochemistry
Fri Mar 13 00:00:00 UTC 2020
Phototoxic damage to cone photoreceptors can be independent of the visual pigment: the porphyrin hypothesis.
Cell death & disease
Marie M,Forster V,Fouquet S,Berto P,Barrau C,Ehrismann C,Sahel JA,Tessier G,Picaud S
A-21351 was used in Immunohistochemistry to investigate the effect of light on cone survival from 390 to 510 nm in 10 nm steps, plus the 630 nm band. If at a given intensity (0.2 mW/cm²), the most toxic wavelengths are comprised in the visible-to-near-UV range, they shift to blue-violet light (425-445 nm) when exposing cells to a solar source filtered by the eye optics.
Sat Aug 29 00:00:00 UTC 2020
Phototoxic damage to cone photoreceptors can be independent of the visual pigment: the porphyrin hypothesis.
Cell death & disease
Marie M,Forster V,Fouquet S,Berto P,Barrau C,Ehrismann C,Sahel JA,Tessier G,Picaud S
A-21351 was used in Immunohistochemistry to investigate the effect of light on cone survival from 390 to 510 nm in 10 nm steps, plus the 630 nm band. If at a given intensity (0.2 mW/cm²), the most toxic wavelengths are comprised in the visible-to-near-UV range, they shift to blue-violet light (425-445 nm) when exposing cells to a solar source filtered by the eye optics.
Sat Aug 29 00:00:00 UTC 2020
Inactivation of the mitochondrial protease Afg3l2 results in severely diminished respiratory chain activity and widespread defects in mitochondrial gene expression.
PLoS genetics
Pareek G,Pallanck LJ
A-21351 was used in Western Blotting to explore the biological role of the m-AAA proteases and the pathological consequences of their deficiency.
Thu Oct 01 00:00:00 UTC 2020
Inactivation of the mitochondrial protease Afg3l2 results in severely diminished respiratory chain activity and widespread defects in mitochondrial gene expression.
PLoS genetics
Pareek G,Pallanck LJ
A-21351 was used in Western Blotting to explore the biological role of the m-AAA proteases and the pathological consequences of their deficiency.
Thu Oct 01 00:00:00 UTC 2020
Protein kinase Cα mediates recovery of renal and mitochondrial functions following acute injury.
The FEBS journal
Nowak G,Megyesi J
A-21351 was used in Western Blotting to elucidate that PKCα deletion: (a) affects renal physiology by decreasing mitochondrial capacity for maximum respiration; (b) blocks recovery of mitochondrial functions, renal morphology, and functions after AKI; and (c) decreases survival after AKI.
Fri May 01 00:00:00 UTC 2020
The short variant of optic atrophy 1 (OPA1) improves cell survival under oxidative stress.
The Journal of biological chemistry
Lee H,Smith SB,Sheu SS,Yoon Y
A-21351 was used in Immunohistochemistry to show that cells unable to generate S-OPA1 are more sensitive to this stress under obligatory respiratory conditions, leading to necrotic death.
Fri May 08 00:00:00 UTC 2020
Inhibition of the ubiquitous calpains protects complex I activity and enables improved mitophagy in the heart following ischemia-reperfusion.
American journal of physiology. Cell physiology
Chen Q,Thompson J,Hu Y,Dean J,Lesnefsky EJ
A-21351 was used in Western Blotting to show that activation of both cytosolic and mitochondrial calpains impairs mitochondria during cardiac ISC-REP. Mitochondria-localised calpains impair complex I via cleavage for a key subunit.
Fri Nov 01 00:00:00 UTC 2019
Peroxisomes control mitochondrial dynamics and the mitochondrion-dependent apoptosis pathway.
Journal of cell science
Tanaka H,Okazaki T,Aoyama S,Yokota M,Koike M,Okada Y,Fujiki Y,Gotoh Y
A-21351 was used in Immunocytochemistry-immunoflourescence to show peroxisomes regulate mitochrondrial dynamics and mitrochondrion-dependent apoptosis.
Fri May 31 00:00:00 UTC 2019
Renal cold storage followed by transplantation impairs proteasome function and mitochondrial protein homeostasis.
American journal of physiology. Renal physiology
Lo S,MacMillan-Crow LA,Parajuli N
A-21351 was used in Western Blotting to mitochondrial dysfunction following renal cold storage, transplantation and autotransplantation and the role of the proteosome in this.
Tue Jan 01 00:00:00 UTC 2019
Renal cold storage followed by transplantation impairs proteasome function and mitochondrial protein homeostasis.
American journal of physiology. Renal physiology
Lo S,MacMillan-Crow LA,Parajuli N
A-21351 was used in Western Blotting to mitochondrial dysfunction following renal cold storage, transplantation and autotransplantation and the role of the proteosome in this.
Tue Jan 01 00:00:00 UTC 2019
Mitochondrial ATP synthase β-subunit production rate and ATP synthase specific activity are reduced in skeletal muscle of humans with obesity.
Experimental physiology
Tran L,Langlais PR,Hoffman N,Roust L,Katsanos CS
A-21351 was used in Western Blotting to indicate that reduced production of subunits forming the ATP synthase in muscle may contribute to impaired generation of ATP in obesity.
Tue Jan 01 00:00:00 UTC 2019
Age-related sex differences in the expression of important disease-linked mitochondrial proteins in mice.
Biology of sex differences
Moschinger M,Hilse KE,Rupprecht A,Zeitz U,Erben RG,Rülicke T,Pohl EE
A-21351 was used in Western Blotting to demonstrate that levels of UCP1 and UCP3 protein expression differ between females and males in an age-dependent manner; that pre-pubertal expression of most proteins does not depend on the sex of the mouse; and that expression of VDAC1 and actin is tissue-specifically influenced by sex and age.
Thu Dec 05 00:00:00 UTC 2019
Human bone marrow adipocytes display distinct immune regulatory properties.
EBioMedicine
Miggitsch C,Meryk A,Naismith E,Pangrazzi L,Ejaz A,Jenewein B,Wagner S,Nägele F,Fenkart G,Trieb K,Zwerschke W,Grubeck-Loebenstein B
Published figure using ATP Synthase beta monoclonal antibody (Product # A-21351) in Immunohistochemistry
Thu Aug 01 00:00:00 UTC 2019
PINK1 phosphorylates ubiquitin predominantly in astrocytes.
NPJ Parkinson's disease
Barodia SK,McMeekin LJ,Creed RB,Quinones EK,Cowell RM,Goldberg MS
Published figure using ATP Synthase beta monoclonal antibody (Product # A-21351) in Immunocytochemistry
Tue Sep 29 00:00:00 UTC 2020
A Mammalian Mitophagy Receptor, Bcl2-L-13, Recruits the ULK1 Complex to Induce Mitophagy.
Cell reports
Murakawa T,Okamoto K,Omiya S,Taneike M,Yamaguchi O,Otsu K
A-21351 was used in Western Blotting to elucidate the molecular machinery involved in Bcl2-L-13-mediated mitophagy.
Tue Jan 08 00:00:00 UTC 2019
CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence.
Nature communications
Crochemore C,Fernández-Molina C,Montagne B,Salles A,Ricchetti M
A-21351 was used in Immunocytochemistry to show that depletion of CSB is the earliest known trigger of p21-dependent replicative senescence.
Fri Dec 06 00:00:00 UTC 2019
Formation of mammalian preribosomes proceeds from intermediate to composed state during ribosome maturation.
The Journal of biological chemistry
Abetov DA,Kiyan VS,Zhylkibayev AA,Sarbassova DA,Alybayev SD,Spooner E,Song MS,Bersimbaev RI,Sarbassov DD
A-21351 was used in Western Blotting to characterise how ribosomes are assembled at nucleolar sites by forming initial pre-ribosomal complexes.
Fri Jul 12 00:00:00 UTC 2019
Parkin is a disease modifier in the mutant SOD1 mouse model of ALS.
EMBO molecular medicine
Palomo GM,Granatiero V,Kawamata H,Konrad C,Kim M,Arreguin AJ,Zhao D,Milner TA,Manfredi G
A-21351 was used in Western Blotting to elucidate the potential role of Parkin as a disease modifier in amyotrophic lateral sclerosis.
Mon Oct 01 00:00:00 UTC 2018
GLUT10 maintains the integrity of major arteries through regulation of redox homeostasis and mitochondrial function.
Human molecular genetics
Syu YW,Lai HW,Jiang CL,Tsai HY,Lin CC,Lee YC
A-21351 was used in Immunocytochemistry-immunoflourescence to study the regulatory mechanisms of Glucose transporter 10 in aortic tissues.
Mon Jan 15 00:00:00 UTC 2018
Light action spectrum on oxidative stress and mitochondrial damage in A2E-loaded retinal pigment epithelium cells.
Cell death & disease
Marie M,Bigot K,Angebault C,Barrau C,Gondouin P,Pagan D,Fouquet S,Villette T,Sahel JA,Lenaers G,Picaud S
Mon Feb 19 00:00:00 UTC 2018
Lon protease inactivation in Drosophila causes unfolded protein stress and inhibition of mitochondrial translation.
Cell death discovery
Pareek G,Thomas RE,Vincow ES,Morris DR,Pallanck LJ
A-21351 was used in Western Blotting to examine the effects of deactivation of the Drosophila matrix-localised AAA+ protease Lon on mitochondrial translation and unfolded protein stress.
Thu Oct 01 00:00:00 UTC 2020
APP promotes osteoblast survival and bone formation by regulating mitochondrial function and preventing oxidative stress.
Cell death & disease
Pan JX,Tang F,Xiong F,Xiong L,Zeng P,Wang B,Zhao K,Guo H,Shun C,Xia WF,Mei L,Xiong WC
A-21351 was used in Western Blotting to identify the function of amyloid precursor protein (APP) in promoting osteoblast survival and bone formation.
Mon Oct 22 00:00:00 UTC 2018
Loss of the Drosophila m-AAA mitochondrial protease paraplegin results in mitochondrial dysfunction, shortened lifespan, and neuronal and muscular degeneration.
Cell death & disease
Pareek G,Thomas RE,Pallanck LJ
A-21351 was used in Western Blotting to investigate the effects of the loss of metazoan mitochondrial AAA+protease family in Drosophila.
Wed Feb 21 00:00:00 UTC 2018
Mitochondrial Retrograde Signaling in Mammals Is Mediated by the Transcriptional Cofactor GPS2 via Direct Mitochondria-to-Nucleus Translocation.
Molecular cell
Cardamone MD,Tanasa B,Cederquist CT,Huang J,Mahdaviani K,Li W,Rosenfeld MG,Liesa M,Perissi V
A-21351 was used in Immunocytochemistry to reveal an additional layer of regulation of mitochondrial gene transcription, uncover a direct mitochondria-nuclear communication pathway, and indicate that GPS2 retrograde signaling is a key component of the mitochondrial stress response in mammals.
Thu Mar 01 00:00:00 UTC 2018
Receptor-mediated Drp1 oligomerization on endoplasmic reticulum.
The Journal of cell biology
Ji WK,Chakrabarti R,Fan X,Schoenfeld L,Strack S,Higgs HN
A-21351 was used in Western Blotting to study a population of Drp1 oligomers associated with the endoplasmic reticulum in mammalian cells that is distinct from mitochondrial and peroxisomal Drp1 populations.
Mon Dec 04 00:00:00 UTC 2017
Differential Alterations of the Mitochondrial Morphology and Respiratory Chain Complexes during Postnatal Development of the Mouse Lung.
Oxidative medicine and cellular longevity
El-Merhie N,Baumgart-Vogt E,Pilatz A,Pfreimer S,Pfeiffer B,Pak O,Kosanovic D,Seimetz M,Schermuly RT,Weissmann N,Karnati S
Published figure using ATP Synthase beta monoclonal antibody (Product # A-21351) in Western Blot
Thu Aug 09 00:00:00 UTC 2018
The Transcription Factor 7-Like 2-Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1 Alpha Axis Connects Mitochondrial Biogenesis and Metabolic Shift with Stem Cell Commitment to Hepatic Differentiation.
Stem cells (Dayton, Ohio)
Wanet A,Caruso M,Domelevo Entfellner JB,Najar M,Fattaccioli A,Demazy C,Evraerts J,El-Kehdy H,Pourcher G,Sokal E,Arnould T,Tiffin N,Najimi M,Renard P
A-21351 was used in Western Blotting to identify a transcriptional regulatory axis, coupling the loss of pluripotency and early commitment to differentiation, to the initiation of mitochondrial biogenesis and metabolic shift toward oxidative phosphorylation.
Sun Oct 01 00:00:00 UTC 2017
OPA1 haploinsufficiency induces a BNIP3-dependent decrease in mitophagy in neurons: relevance to Dominant Optic Atrophy.
Journal of neurochemistry
Moulis MF,Millet AM,Daloyau M,Miquel MC,Ronsin B,Wissinger B,Arnauné-Pelloquin L,Belenguer P
A21351 was used in immunocytochemistry to explore how the relationship between OPA1 and BNIP3 impacts dominant optic atrophy pathogenesis
Wed Feb 01 00:00:00 UTC 2017
Impaired Mitophagy Plays a Role in Denervation of Neuromuscular Junctions in ALS Mice.
Frontiers in neuroscience
Rogers RS,Tungtur S,Tanaka T,Nadeau LL,Badawi Y,Wang H,Ni HM,Ding WX,Nishimune H
Published figure using ATP Synthase beta monoclonal antibody (Product # A-21351) in Immunohistochemistry
Thu Oct 01 00:00:00 UTC 2020
Role for the ATPase inhibitory factor 1 in the environmental carcinogen-induced Warburg phenotype.
Scientific reports
Hardonnière K,Fernier M,Gallais I,Mograbi B,Podechard N,Le Ferrec E,Grova N,Appenzeller B,Burel A,Chevanne M,Sergent O,Huc L,Bortoli S,Lagadic-Gossmann D
Published figure using ATP Synthase beta monoclonal antibody (Product # A-21351) in Western Blot
Wed Mar 15 00:00:00 UTC 2017
The short variant of the mitochondrial dynamin OPA1 maintains mitochondrial energetics and cristae structure.
The Journal of biological chemistry
Lee H,Smith SB,Yoon Y
A-21351 was used in Western Blotting to study the ability of short protein optic atrophy 1 to maintain mitochondrial energetics and cristae structure.
Fri Apr 28 00:00:00 UTC 2017
Apoptosis-Inducing-Factor-Dependent Mitochondrial Function Is Required for T Cell but Not B Cell Function.
Immunity
Milasta S,Dillon CP,Sturm OE,Verbist KC,Brewer TL,Quarato G,Brown SA,Frase S,Janke LJ,Perry SS,Thomas PG,Green DR
Published figure using ATP Synthase beta monoclonal antibody (Product # A-21351) in Western Blot
Tue Jan 19 00:00:00 UTC 2016
Amyloid β-peptides interfere with mitochondrial preprotein import competence by a coaggregation process.
Molecular biology of the cell
Cenini G,Rüb C,Bruderek M,Voos W
A21351 was used in western blot to show direct interference of aggregation-prone Abeta peptides with mitochondrial protein biogenesis
Tue Nov 01 00:00:00 UTC 2016
Estrogen-related receptor α (ERRα) and ERRγ are essential coordinators of cardiac metabolism and function.
Molecular and cellular biology
Wang T,McDonald C,Petrenko NB,Leblanc M,Wang T,Giguere V,Evans RM,Patel VV,Pei L
Published figure using ATP Synthase beta monoclonal antibody (Product # A-21351) in Immunofluorescence
Wed Apr 01 00:00:00 UTC 2015
In vivo time-lapse imaging of mitochondria in healthy and diseased peripheral myelin sheath.
Mitochondrion
Gonzalez S,Fernando R,Berthelot J,Perrin-Tricaud C,Sarzi E,Chrast R,Lenaers G,Tricaud N
A-21351 was used in immunohistochemistry to study mitochondrial dynamics and morphology in myelinating Schwann cells in living mice.
Wed Jul 01 00:00:00 UTC 2015
Assembly of human mitochondrial ATP synthase through two separate intermediates, F1-c-ring and b-e-g complex.
FEBS letters
Fujikawa M,Sugawara K,Tanabe T,Yoshida M
A-21351 was used in western blot to study the assembly process of human mitochondrial ATP synthase
Mon Sep 14 00:00:00 UTC 2015
Proteomic analysis of the palmitoyl protein thioesterase 1 interactome in SH-SY5Y human neuroblastoma cells.
Journal of proteomics
Scifo E,Szwajda A,Soliymani R,Pezzini F,Bianchi M,Dapkunas A,Dębski J,Uusi-Rauva K,Dadlez M,Gingras AC,Tyynelä J,Simonati A,Jalanko A,Baumann MH,Lalowski M
A-21351 was used in western blot to identify substrates of human PPT using neuronal cells.
Thu Jun 18 00:00:00 UTC 2015
Apolipoprotein A-I enhances proliferation of human endothelial progenitor cells and promotes angiogenesis through the cell surface ATP synthase.
Microvascular research
González-Pecchi V,Valdés S,Pons V,Honorato P,Martinez LO,Lamperti L,Aguayo C,Radojkovic C
A-21351 was used in flow cytometry and immunocytochemistry to examine the effect of apoA-I in the proliferation and the angiogenic capacity of early hEPC.
Sun Mar 01 00:00:00 UTC 2015
Quantitative analysis of PPT1 interactome in human neuroblastoma cells.
Data in brief
Scifo E,Szwajda A,Soliymani R,Pezzini F,Bianchi M,Dapkunas A,Dębski J,Uusi-Rauva K,Dadlez M,Gingras AC,Tyynelä J,Simonati A,Jalanko A,Baumann MH,Lalowski M
A-21351 was used in western blot to examine palmitoyl protein thioesterase.
Tue Sep 01 00:00:00 UTC 2015
Analysis of nuclear RNA interference in human cells by subcellular fractionation and Argonaute loading.
Nature protocols
Gagnon KT,Li L,Janowski BA,Corey DR
A-21351 was used in Western Blotting to develop a simplified protocol for nuclei isolation from cultured cells that incorporates a method for obtaining nucleoplasmic and chromatin fractions and removing cytoplasmic contamination.
Mon Sep 01 00:00:00 UTC 2014
Neuroglobin gene therapy prevents optic atrophy and preserves durably visual function in Harlequin mice.
Molecular therapy : the journal of the American Society of Gene Therapy
Lechauve C,Augustin S,Cwerman-Thibault H,Reboussin É,Roussel D,Lai-Kuen R,Saubamea B,Sahel JA,Debeir T,Corral-Debrinski M
Published figure using ATP Synthase beta monoclonal antibody (Product # A-21351) in Western Blot
Sun Jun 01 00:00:00 UTC 2014
High-fat diet-induced impairment of skeletal muscle insulin sensitivity is not prevented by SIRT1 overexpression.
American journal of physiology. Endocrinology and metabolism
White AT,Philp A,Fridolfsson HN,Schilling JM,Murphy AN,Hamilton DL,McCurdy CE,Patel HH,Schenk S
A-21351 was used in western blot to test if constitutive activation of SIRT1 in skeletal muscle prevents high fat diet-induced muscle insulin resistance
Sat Nov 01 00:00:00 UTC 2014
A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer.
Disease models & mechanisms
Burman JL,Itsara LS,Kayser EB,Suthammarak W,Wang AM,Kaeberlein M,Sedensky MM,Morgan PG,Pallanck LJ
A-21351 was used in western blot to elucidate the mechanisms by which complex I dysfunction contribute to mitochondrial disease
Wed Oct 01 00:00:00 UTC 2014
Involvement of ATP synthase β subunit in chikungunya virus entry into insect cells.
Archives of virology
Fongsaran C,Jirakanwisal K,Kuadkitkan A,Wikan N,Wintachai P,Thepparit C,Ubol S,Phaonakrop N,Roytrakul S,Smith DR
A-21351 was used in western blot to identify the ATP synthase beta subunit as a mosquito-cell-expressed chikungunya virus-binding protein
Mon Dec 01 00:00:00 UTC 2014
Population of ATP synthase molecules in mitochondria is limited by available 6.8-kDa proteolipid protein (MLQ).
Genes to cells : devoted to molecular & cellular mechanisms
Fujikawa M,Ohsakaya S,Sugawara K,Yoshida M
A-21351 was used in immunocytochemistry to investigate MLQ as a regulator of mitochondrial ATP synthesis.
Sat Feb 01 00:00:00 UTC 2014
Population of ATP synthase molecules in mitochondria is limited by available 6.8-kDa proteolipid protein (MLQ).
Genes to cells : devoted to molecular & cellular mechanisms
Fujikawa M,Ohsakaya S,Sugawara K,Yoshida M
A-21351 was used in immunocytochemistry to investigate MLQ as a regulator of mitochondrial ATP synthesis.
Sat Feb 01 00:00:00 UTC 2014
PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix.
PLoS genetics
Thomas RE,Andrews LA,Burman JL,Lin WY,Pallanck LJ
A-21351 was used in western blot to investigate how PINK1 is degraded.
Mon Dec 15 00:00:00 UTC 2014
PINK1-Parkin pathway activity is regulated by degradation of PINK1 in the mitochondrial matrix.
PLoS genetics
Thomas RE,Andrews LA,Burman JL,Lin WY,Pallanck LJ
A-21351 was used in western blot to investigate how PINK1 is degraded.
Mon Dec 15 00:00:00 UTC 2014
Advanced oxidation protein products induce cardiomyocyte death via Nox2/Rac1/superoxide-dependent TRAF3IP2/JNK signaling.
Free radical biology & medicine
Valente AJ,Yoshida T,Clark RA,Delafontaine P,Siebenlist U,Chandrasekar B
A-21351 was used in western blot to identify the mechanism for the cardiomyocyte death induced by advanced oxidation protein products.
Mon Jul 01 00:00:00 UTC 2013
The N-terminal helix of Bcl-xL targets mitochondria.
Mitochondrion
McNally MA,Soane L,Roelofs BA,Hartman AL,Hardwick JM
A-21351 was used in western blot to test if the N-terminus of Bcl-xL contains a mitochondrial targeting signal.
Fri Mar 01 00:00:00 UTC 2013
IF1, a natural inhibitor of mitochondrial ATP synthase, is not essential for the normal growth and breeding of mice.
Bioscience reports
Nakamura J,Fujikawa M,Yoshida M
A-21351 was used in western blot to characterize a mouse strain in which IF gene was destroyed.
Tue Sep 17 00:00:00 UTC 2013
Reduced mitochondrial ROS, enhanced antioxidant defense, and distinct age-related changes in oxidative damage in muscles of long-lived Peromyscus leucopus.
American journal of physiology. Regulatory, integrative and comparative physiology
Shi Y,Pulliam DA,Liu Y,Hamilton RT,Jernigan AL,Bhattacharya A,Sloane LB,Qi W,Chaudhuri A,Buffenstein R,Ungvari Z,Austad SN,Van Remmen H
Published figure using ATP Synthase beta monoclonal antibody (Product # A-21351) in Western Blot
Fri Mar 01 00:00:00 UTC 2013
Screening of protein kinase inhibitors and knockdown experiments identified four kinases that affect mitochondrial ATP synthesis activity.
FEBS letters
Sugawara K,Fujikawa M,Yoshida M
A-21351 was used in Western Blot to screen 80 protein kinase inhibitors and found that HeLa cells treated with four inhibitors exhibited reduced mitochondrial ATP synthesis activity.
Fri Nov 29 00:00:00 UTC 2013
Mild mitochondrial uncoupling does not affect mitochondrial biogenesis but downregulates pyruvate carboxylase in adipocytes: role for triglyceride content reduction.
American journal of physiology. Endocrinology and metabolism
De Pauw A,Demine S,Tejerina S,Dieu M,Delaive E,Kel A,Renard P,Raes M,Arnould T
A-21351 was used in Western Blotting to investigate the effects of mild mitochondrial uncoupling in adipocytes.
Tue May 15 00:00:00 UTC 2012
Inhibition of tumor cell surface ATP synthesis by pigment epithelium-derived factor: implications for antitumor activity.
International journal of oncology
Deshpande M,Notari L,Subramanian P,Notario V,Becerra SP
A-21351 was used in western blot to study the interactions between the extracellular PEDF and tumor cell surface ATP synthase.
Sun Jul 01 00:00:00 UTC 2012
Assessing actual contribution of IF1, inhibitor of mitochondrial FoF1, to ATP homeostasis, cell growth, mitochondrial morphology, and cell viability.
The Journal of biological chemistry
Fujikawa M,Imamura H,Nakamura J,Yoshida M
A-21351 was used in western blot to study energy metabolism in IF knockdown cells.
Fri May 25 00:00:00 UTC 2012
Examining the interactome of huperzine A by magnetic biopanning.
PloS one
Guo W,Liu S,Peng J,Wei X,Sun Y,Qiu Y,Gao G,Wang P,Xu Y
A-21351 was used in western blot to examine the interactome of Huperzine A.
Tue Jan 08 00:00:00 UTC 2013
The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon.
Cell metabolism
Donohoe DR,Garge N,Zhang X,Sun W,O'Connell TM,Bunger MK,Bultman SJ
A-21351 was used in western blot to study the effects of microbiome-derived butyrate on the energy metabolism of colonocytes.
Wed May 04 00:00:00 UTC 2011
Bcl-xL regulates mitochondrial energetics by stabilizing the inner membrane potential.
The Journal of cell biology
Chen YB,Aon MA,Hsu YT,Soane L,Teng X,McCaffery JM,Cheng WC,Qi B,Li H,Alavian KN,Dayhoff-Brannigan M,Zou S,Pineda FJ,O'Rourke B,Ko YH,Pedersen PL,Kaczmarek LK,Jonas EA,Hardwick JM
Published figure using ATP Synthase beta monoclonal antibody (Product # A-21351) in Western Blot
Mon Oct 17 00:00:00 UTC 2011
Theiler's virus L* protein is targeted to the mitochondrial outer membrane.
Journal of virology
Sorgeloos F,Vertommen D,Rider MH,Michiels T
A-21351 was used in Western Blotting to examine the intracellular localisation of Theiler's murine encephalomyelitis virus L protein in infected cells.
Fri Apr 01 00:00:00 UTC 2011
The PGC-1α-related coactivator promotes mitochondrial and myogenic adaptations in C2C12 myotubes.
American journal of physiology. Regulatory, integrative and comparative physiology
Philp A,Belew MY,Evans A,Pham D,Sivia I,Chen A,Schenk S,Baar K
A-21351 was used in western blot to examine the effect of PGC-α-related coactivator on the metabolic profile of C2C2 myotubes.
Sat Oct 01 00:00:00 UTC 2011
A mutation in a mitochondrial dehydrogenase/reductase gene causes an increased sensitivity to oxidative stress and mitochondrial defects in the nematode Caenorhabditis elegans.
Genes to cells : devoted to molecular & cellular mechanisms
Fujii M,Yasuda K,Hartman PS,Ayusawa D,Ishii N
A-21351 was used in western blot to characterize rad-8 mutants.
Sat Oct 01 00:00:00 UTC 2011
Heterogeneous levels of oxidative phosphorylation enzymes in rat adrenal glands.
Acta histochemica
Ogawa K,Harada K,Endo Y,Sagawa S,Inoue M
A-21351 was used in immunohistochemistry - paraffin section to observe and characterize mitochondria in the rat adrenal gland
Sat Jan 01 00:00:00 UTC 2011
Modes of metabolic compensation during mitochondrial disease using the Drosophila model of ATP6 dysfunction.
PloS one
Celotto AM,Chiu WK,Van Voorhies W,Palladino MJ
A-21351 was used in western blot to investigate metabolic changes in a Drosophila model of human mitochondrial encephalomyopathy
Mon Feb 06 00:00:00 UTC 2012
Knockdown of DAPIT (diabetes-associated protein in insulin-sensitive tissue) results in loss of ATP synthase in mitochondria.
The Journal of biological chemistry
Ohsakaya S,Fujikawa M,Hisabori T,Yoshida M
A-21351 was used in western blot to investigate the contribution of diabetes-associated protein in insulin-sensitive tissue to ATP synthesis.
Fri Jun 10 00:00:00 UTC 2011
Identification of human fumarylacetoacetate hydrolase domain-containing protein 1 (FAHD1) as a novel mitochondrial acylpyruvase.
The Journal of biological chemistry
Pircher H,Straganz GD,Ehehalt D,Morrow G,Tanguay RM,Jansen-Dürr P
A-21351 was used in western blot to determine the enzymatic function of FAHD1.
Fri Oct 21 00:00:00 UTC 2011
The GTPase RAB20 is a HIF target with mitochondrial localization mediating apoptosis in hypoxia.
Biochimica et biophysica acta
Hackenbeck T,Huber R,Schietke R,Knaup KX,Monti J,Wu X,Klanke B,Frey B,Gaipl U,Wullich B,Ferbus D,Goubin G,Warnecke C,Eckardt KU,Wiesener MS
A-21351 was used in western blot to characterize Rab20, a hypoxia-induced gene
Sat Jan 01 00:00:00 UTC 2011
Pyruvate suppresses PGC1alpha expression and substrate utilization despite increased respiratory chain content in C2C12 myotubes.
American journal of physiology. Cell physiology
Philp A,Perez-Schindler J,Green C,Hamilton DL,Baar K
A-21351 was used in western blot to study the effects of osmotic changes on the regulation of mitochondrial metabolism and biogenesis in C2C12 myotubes
Sun Aug 01 00:00:00 UTC 2010
WNT1-inducible signaling pathway protein-1 activates diverse cell survival pathways and blocks doxorubicin-induced cardiomyocyte death.
Cellular signalling
Venkatesan B,Prabhu SD,Venkatachalam K,Mummidi S,Valente AJ,Clark RA,Delafontaine P,Chandrasekar B
A-21351 was used in western blot to identify doxorubicin-induced alterations in adult mouse cardiomyocytes
Sat May 01 00:00:00 UTC 2010
A sensitive, simple assay of mitochondrial ATP synthesis of cultured mammalian cells suitable for high-throughput analysis.
Biochemical and biophysical research communications
Fujikawa M,Yoshida M
A-21351 was used in western blot to establish an assay for measuring mitochondrial ATP synthesis in cultured mammalian cells
Fri Oct 29 00:00:00 UTC 2010
The proteome of human brain after ischemic stroke.
Journal of neuropathology and experimental neurology
Cuadrado E,Rosell A,Colomé N,Hernández-Guillamon M,García-Berrocoso T,Ribo M,Alcazar A,Ortega-Aznar A,Salinas M,Canals F,Montaner J
A-21351 was used in western blot to determine the proteome of the ischemic human brain.
Mon Nov 01 00:00:00 UTC 2010
The mitochondrial fusion-promoting factor mitofusin is a substrate of the PINK1/parkin pathway.
PloS one
Poole AC,Thomas RE,Yu S,Vincow ES,Pallanck L
Published figure using ATP Synthase beta monoclonal antibody (Product # A-21351) in Western Blot
Wed Apr 07 00:00:00 UTC 2010
Cisd2 deficiency drives premature aging and causes mitochondria-mediated defects in mice.
Genes & development
Chen YF,Kao CH,Chen YT,Wang CH,Wu CY,Tsai CY,Liu FC,Yang CW,Wei YH,Hsu MT,Tsai SF,Tsai TF
Published figure using ATP Synthase beta monoclonal antibody (Product # A-21351) in Western Blot
Fri May 15 00:00:00 UTC 2009
Bz-423 superoxide signals B cell apoptosis via Mcl-1, Bak, and Bax.
Biochemical pharmacology
Blatt NB,Boitano AE,Lyssiotis CA,Opipari AW,Glick GD
A-21351 was used in western blot to describe the signaling pathway engaged by Bz-423 in a Burkitt lymphoma cell line
Thu Oct 15 00:00:00 UTC 2009
Histochemical methods for the diagnosis of mitochondrial diseases.
Current protocols in human genetics
De Paepe B,De Bleecker JL,Van Coster R
A-21351 was used in immunocytochemistry, immunohistochemistry - frozen section, and immunohistochemistry - paraffin section to review methods to study oxidative phosphorylation
Thu Oct 01 00:00:00 UTC 2009
Bz-423 superoxide signals apoptosis via selective activation of JNK, Bak, and Bax.
Free radical biology & medicine
Blatt NB,Boitano AE,Lyssiotis CA,Opipari AW,Glick GD
A-21351 was used in western blot to identify the signaling pathway activated by Bz-423 in mouse embryonic fibroblasts
Sat Nov 01 00:00:00 UTC 2008
Dual functions of a monoclonal antibody against cell surface F1F0 ATP synthase on both HUVEC and tumor cells.
Acta pharmacologica Sinica
Zhang X,Gao F,Yu LL,Peng Y,Liu HH,Liu JY,Yin M,Ni J
A-21351 was used in Flow cytometry/Cell sorting to investigate how McAb178-5G10 binds preferentially to cell surface ATPase, blocks ATP synthesis, and exhibits both antiangiogenic and antitumorigenic effects.
Fri Aug 01 00:00:00 UTC 2008
Mitochondrial proteomics of the retinal pigment epithelium at progressive stages of age-related macular degeneration.
Investigative ophthalmology & visual science
Nordgaard CL,Karunadharma PP,Feng X,Olsen TW,Ferrington DA
A-21351 was used in western blot to examine the subproteome of mitochondria isolated from human donor retinal pigment epithelium graded with the Minnesota Grading System
Tue Jul 01 00:00:00 UTC 2008
Subdiffraction-resolution fluorescence imaging of proteins in the mitochondrial inner membrane with photoswitchable fluorophores.
Journal of structural biology
van de Linde S,Sauer M,Heilemann M
A-21351 was used in immunocytochemistry to show that commercially available standard fluorescent probes are efficient photoswitches
Mon Dec 01 00:00:00 UTC 2008
Motor neuron degeneration in amyotrophic lateral sclerosis mutant superoxide dismutase-1 transgenic mice: mechanisms of mitochondriopathy and cell death.
The Journal of comparative neurology
Martin LJ,Liu Z,Chen K,Price AC,Pan Y,Swaby JA,Golden WC
A-21351 was used in western blot to examine the neuronal cell death in the spinal cords of mSOD1 and wtSOD1 mice.
Mon Jan 01 00:00:00 UTC 2007
2,2'-thiodiethanol: a new water soluble mounting medium for high resolution optical microscopy.
Microscopy research and technique
Staudt T,Lang MC,Medda R,Engelhardt J,Hell SW
A-21351 was used in immunocytochemistry to characterize a new water soluble mounting medium called 2,2'-thiodiethanol, that is used for high resolution optical microscopy
Mon Jan 01 00:00:00 UTC 2007
Differential expression proteomics of human colon cancer.
American journal of physiology. Gastrointestinal and liver physiology
Mazzanti R,Solazzo M,Fantappié O,Elfering S,Pantaleo P,Bechi P,Cianchi F,Ettl A,Giulivi C
A-21351 was used in western blot study operative pathways in early stages of human colon cancer
Thu Jun 01 00:00:00 UTC 2006
Coordination of nuclear- and mitochondrial-DNA encoded proteins in cancer and normal colon tissues.
Biochimica et biophysica acta
Mazzanti R,Giulivi C
A-21351 was used in western blot to investigate how oxidative phosphorylation contributes to the coordination between nuclear- and mitochondria-encoded mitochondrial proteins
Fri Sep 29 00:00:00 UTC 2006
