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ATP1A2/ATP1A3 Polyclonal Antibody

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Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

OSA00277W-100UL

Applications
Tested Dilution
Publications

Western Blot (WB)

1:300-1:2,000
-

Immunohistochemistry (IHC)

1:300-1:2,000
-
Product Specifications

Species Reactivity

Human, Mouse, Rat

Host/Isotype

Rabbit / Ig

Class

Polyclonal

Type

Antibody

Immunogen

A synthetic peptide from aa region 970-1013 of human ATP1A3 conjugated to blue carrier protein was used as the antigen
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Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Concentration

Conc. Not Determined

Storage buffer

whole serum

Contains

no preservative

Storage conditions

Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Glycerol (1:1) may be added for added stability.

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Reconstitute in 100 µL of sterile water. Centrifuge to remove any insoluble material.

The peptide is homologous in rat and mouse and shares 95% identity with rat and mouse ATP1A2 sequences.

Specificity of this antibody: ATP1A3 and ATP1A2.

Target Information

The protein encoded by these genes belong to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes [provided by RefSeq, Oct 2008]

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: ATPase Na+/K+ transporting alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 2 polypeptide; ATPase, Na+/K+ transporting, alpha 3 polypeptide; ATPase, Na+K+ transporting, alpha 2; ATPase, Na+K+ transporting, alpha 3 subunit; Na(+)/K(+) ATPase alpha(+) subunit; Na(+)/K(+) ATPase alpha(III) subunit; Na(+)/K(+) ATPase alpha-2 subunit; Na(+)/K(+) ATPase alpha-3 subunit; Na+, K+ activated adenosine triphosphatase alpha subunit; Na+/K+ -ATPase alpha 2 subunit; Na+/K+ -ATPase alpha 3 subunit; Na+/K+ ATPase 3; Na+/K+ ATPase, alpha-A(+) catalytic polypeptide; Na+/K+ ATPase, alpha-B polypeptide; Sodium pump subunit alpha-2; Sodium pump subunit alpha-3; sodium-potassium ATPase catalytic subunit alpha-2; sodium-potassium ATPase catalytic subunit alpha-3; sodium-potassium-ATPase, alpha 3 polypeptide; sodium/potassium-transporting ATPase alpha-2 chain; sodium/potassium-transporting ATPase alpha-3 chain; Sodium/potassium-transporting ATPase subunit alpha-2; Sodium/potassium-transporting ATPase subunit alpha-3

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Gene Aliases: AHC2; ATP1A1; ATP1A2; ATP1A3; Atpa-2; Atpa-3; Atpa1a3; AW060654; CAPOS; DYT12; FHM2; KIAA0778; MHP2; mKIAA0778; RATATPA2; RDP

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UniProt ID: (Human) P50993, (Human) P13637, (Rat) P06686, (Mouse) Q6PIE5, (Rat) P06687, (Mouse) Q6PIC6

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Entrez Gene ID: (Human) 477, (Human) 478, (Rat) 24212, (Mouse) 98660, (Rat) 24213, (Mouse) 232975

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Function(s)
sodium:potassium-exchanging ATPase activity protein binding ATP binding drug binding ATPase activity potassium ion binding sodium ion binding chaperone binding steroid hormone binding D1 dopamine receptor binding heparan sulfate proteoglycan binding metal ion binding sodium:potassium-exchanging ATPase activity involved in regulation of cardiac muscle cell membrane potential cation-transporting ATPase activity nucleotide binding hydrolase activity
Process(es)
neurotransmitter uptake regulation of the force of heart contraction regulation of respiratory gaseous exchange by neurological system process potassium ion transport sodium ion transport cellular sodium ion homeostasis regulation of muscle contraction regulation of smooth muscle contraction regulation of striated muscle contraction metabolic process regulation of blood pressure adult locomotory behavior visual learning potassium ion import regulation of cardiac muscle contraction by calcium ion signaling energy coupled proton transmembrane transport, against electrochemical gradient ATP hydrolysis coupled proton transport regulation of vasoconstriction cellular potassium ion homeostasis response to nicotine sodium ion export from cell locomotion negative regulation of heart contraction negative regulation of striated muscle contraction negative regulation of cytosolic calcium ion concentration relaxation of cardiac muscle cardiac muscle contraction cellular response to mechanical stimulus cellular response to steroid hormone stimulus regulation of cardiac muscle cell contraction negative regulation of calcium ion transmembrane transport negative regulation of calcium:sodium antiporter activity response to glycoside memory ionotropic glutamate receptor signaling pathway response to drug transport ion transport sodium ion transmembrane transport potassium ion transmembrane transport regulation of cardiac muscle cell membrane potential establishment or maintenance of transmembrane electrochemical gradient regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion ion transmembrane transport ATP metabolic process regulation of glutamate uptake involved in transmission of nerve impulse regulation of synaptic transmission, glutamatergic membrane repolarization membrane depolarization during cardiac muscle cell action potential cell communication by electrical coupling involved in cardiac conduction regulation of cardiac conduction potassium ion import across plasma membrane
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