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Invitrogen
ATP1A2 Recombinant Rabbit Monoclonal Antibody (5T3O4)
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FIGURE: 1 / 1
ATP1A2 Antibody (MA5-37905) in WB
Western blot analysis of ATP1A2 in extracts of various cell lines. Samples were incubated with ATP1A2 Monoclonal antibody (Product # MA5-37905) using a dilution of 1:1,000, followed by HRP Goat Anti-Rabbit IgG (H+L) at a dilution of 1:10,000. Lysates/proteins: 25 µg per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.
Product Details
MA5-37905
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
HEK293 cells
Class
Recombinant Monoclonal
Type
Antibody
Clone
5T3O4
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ATP1A2 (P50993)
Conjugate
Form
Liquid
Concentration
0.8 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol, 0.05% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2897825
Product Specific Information
Positive Samples: Mouse heart, Mouse skeletal muscle, Rat heart
Immunogen sequence: MGRGAGREYS PAATTAENGG GKKKQKEKEL DELKKEVAMD DHKLSLDELG RKYQVDLSKG LTNQRAQDVL ARDGPNALTP PPTTPEWVKF CRQLFGGFSI
Target Information
Atp1a2 encodes an Na+/K+ ATPase, which is a membrane protein that is composed of two subunits - alpha and beta. The Na+/K+ ATPase pump maintains an essential electrochemical gradient within cells through the active transport of sodium (Na+) and potassium (K+) ions. The Atp1a2 encoded protein belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These ion gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. The ATPase enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta), and the catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. The Atp1a2 gene encodes an alpha 2 subunit. Mutations in the Atp1a2 gene result in familial basilar or hemiplegic migraines, and in a rare syndrome known as alternating hemiplegia of childhood. Diseases associated with ATP1A2 include Alternating Hemiplegia Of Childhood and Migraine, Familial Hemiplegic, 2.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATPase, Na+K+ transporting, alpha 2; Na(+)/K(+) ATPase alpha(+) subunit; Na(+)/K(+) ATPase alpha-2 subunit; Na+/K+ -ATPase alpha 2 subunit; Sodium Potassium ATPase; Sodium pump subunit alpha-2; Sodium/potassium-transporting ATPase subunit alpha-2
Gene Aliases: Atp1a2; Atpa-3; AW060654; mKIAA0778; RATATPA2
UniProt ID: (Rat) P06686, (Mouse) Q6PIE5
Entrez Gene ID: (Rat) 24212, (Mouse) 98660
neurotransmitter uptake
regulation of the force of heart contraction
regulation of respiratory gaseous exchange by neurological system process
potassium ion transport
sodium ion transport
cellular sodium ion homeostasis
regulation of muscle contraction
regulation of smooth muscle contraction
regulation of striated muscle contraction
metabolic process
regulation of blood pressure
adult locomotory behavior
visual learning
potassium ion import
regulation of cardiac muscle contraction by calcium ion signaling
energy coupled proton transmembrane transport, against electrochemical gradient
ATP hydrolysis coupled proton transport
regulation of vasoconstriction
cellular potassium ion homeostasis
response to nicotine
sodium ion export from cell
locomotion
negative regulation of heart contraction
negative regulation of striated muscle contraction
negative regulation of cytosolic calcium ion concentration
relaxation of cardiac muscle
cardiac muscle contraction
cellular response to mechanical stimulus
cellular response to steroid hormone stimulus
regulation of cardiac muscle cell contraction
negative regulation of calcium ion transmembrane transport
negative regulation of calcium:sodium antiporter activity
response to glycoside
transport
ion transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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