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ATP1B2 Polyclonal Antibody

ATP1B2 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ATP1B2 Antibody (22338-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human brain slide using 22338-1-AP ( ATP1B2 Antibody) at dilution of 1:50.

ATP1B2 Antibody in Immunoprecipitation (IP)

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Product Details

22338-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 9 publications 9 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

0.5-4.0 µg

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Mouse, Rat

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ATP1B2 Fusion Protein Ag17818 (64-171 aa encoded by BC126175)

View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.34 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

This antibody recognizes the endogenous ATP1B2 protein in human brain. The bands between 45 kDa and 65 kDa represent the glycosylated forms of ATP1B2 in different levels.

Immunogen sequence: QTVSDHTPK YQDRLATPGL MIRPKTENLD VIVNVSDTES WDQHVQKLNK FLEPYNDSIQ AQKNDVCRPG RYYEQPDNGV LNYPKRACQF NRTQLGNCSG IGDSTHYGY (64-171 aa encoded by BC126175)

Target Information

This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na+ and K+ ions across the plasma membrane. The exact function of the beta-2 subunit is not known. Mediates cell adhesion of neurons and astrocytes, and promotes neurite outgrowth.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Altered expression levels of miR-144-3p and ATP1B2 are associated with schizophrenia.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry

Pan B,Wang Y,Shi Y,Yang Q,Han B,Zhu X,Liu Y

Tue Nov 01 00:00:00 UTC 2022

Effects of icariin on alleviating schizophrenia-like symptoms by regulating the miR-144-3p/ATP1B2/mTOR signalling pathway.

Neuroscience letters

Pan B,Xu L,Weng J,Wang Y,Ji H,Han B,Zhu X,Liu Y

Sun Nov 20 00:00:00 UTC 2022

Resistance training upregulates skeletal muscle Na⁺, K⁺-ATPase content, with elevations in both α₁ and α₂, but not β isoforms.

European journal of applied physiology

Altarawneh MM,Petersen AC,Farr T,Garnham A,Broatch JR,Halson S,Bishop DJ,McKenna MJ

Sat Aug 01 00:00:00 UTC 2020

Effects of testosterone suppression, hindlimb immobilization, and recovery on [³H]ouabain binding site content and Na⁺, K⁺-ATPase isoforms in rat soleus muscle.

Journal of applied physiology (Bethesda, Md. : 1985)

Altarawneh MM,Hanson ED,Betik AC,Petersen AC,Hayes A,McKenna MJ

Sun Mar 01 00:00:00 UTC 2020

Spider venom components decrease glioblastoma cell migration and invasion through RhoA-ROCK and Na⁺/K⁺-ATPase β2: potential molecular entities to treat invasive brain cancer.

Cancer cell international

Barreto N,Caballero M,Bonfanti AP,de Mato FCP,Munhoz J,da Rocha-E-Silva TAA,Sutti R,Vitorino-Araujo JL,Verinaud L,Rapôso C

Thu Dec 17 00:00:00 UTC 2020

Isobaric Tagging for Relative and Absolute Protein Quantification (iTRAQ)-Based Quantitative Proteomics Analysis of Differentially Expressed Proteins 1 Week After Spinal Cord Injury in a Rat Model.

Medical science monitor : international medical journal of experimental and clinical research

Liu S,Kang Y,Zhang C,Lou Y,Li X,Lu L,Qi Z,Jian H,Zhou H

Wed Nov 04 00:00:00 UTC 2020

ARL13B, a Joubert Syndrome-Associated Protein, Is Critical for Retinogenesis and Elaboration of Mouse Photoreceptor Outer Segments.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Dilan TL,Moye AR,Salido EM,Saravanan T,Kolandaivelu S,Goldberg AFX,Ramamurthy V

Wed Feb 20 00:00:00 UTC 2019

ARL13B, a Joubert Syndrome-Associated Protein, Is Critical for Retinogenesis and Elaboration of Mouse Photoreceptor Outer Segments.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Dilan TL,Moye AR,Salido EM,Saravanan T,Kolandaivelu S,Goldberg AFX,Ramamurthy V

Wed Feb 20 00:00:00 UTC 2019

ARL13B, a Joubert Syndrome-Associated Protein, Is Critical for Retinogenesis and Elaboration of Mouse Photoreceptor Outer Segments.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Dilan TL,Moye AR,Salido EM,Saravanan T,Kolandaivelu S,Goldberg AFX,Ramamurthy V

Wed Feb 20 00:00:00 UTC 2019

ARL13B, a Joubert Syndrome-Associated Protein, Is Critical for Retinogenesis and Elaboration of Mouse Photoreceptor Outer Segments.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Dilan TL,Moye AR,Salido EM,Saravanan T,Kolandaivelu S,Goldberg AFX,Ramamurthy V

Wed Feb 20 00:00:00 UTC 2019

Cold-water immersion after training sessions: effects on fiber type-specific adaptations in muscle K⁺ transport proteins to sprint-interval training in men.

Journal of applied physiology (Bethesda, Md. : 1985)

Christiansen D,Bishop DJ,Broatch JR,Bangsbo J,McKenna MJ,Murphy RM

Wed Aug 01 00:00:00 UTC 2018

Self-renewing Monolayer of Primary Colonic or Rectal Epithelial Cells.

Cellular and molecular gastroenterology and hepatology

Wang Y,DiSalvo M,Gunasekara DB,Dutton J,Proctor A,Lebhar MS,Williamson IA,Speer J,Howard RL,Smiddy NM,Bultman SJ,Sims CE,Magness ST,Allbritton NL

Sat Jul 01 00:00:00 UTC 2017

Self-renewing Monolayer of Primary Colonic or Rectal Epithelial Cells.

Cellular and molecular gastroenterology and hepatology

Wang Y,DiSalvo M,Gunasekara DB,Dutton J,Proctor A,Lebhar MS,Williamson IA,Speer J,Howard RL,Smiddy NM,Bultman SJ,Sims CE,Magness ST,Allbritton NL

Sat Jul 01 00:00:00 UTC 2017

Redox biology

Luo X,Luo X,Zhu X,Wang G,Ning Z,Li Y,Ma X,Yang R,Jin S,Huang Y,Meng Y,Li X

Sun Oct 01 00:00:00 UTC 2017

Redox biology

Luo X,Luo X,Zhu X,Wang G,Ning Z,Li Y,Ma X,Yang R,Jin S,Huang Y,Meng Y,Li X

Sun Oct 01 00:00:00 UTC 2017

Bioinformatics

Protein Aliases: Adhesion molecule in glia; adhesion molecule on glia; AMOG; ATPase, Na+/K+ transporting, beta 2 polypeptide; ATPase, Na+K+ transporting, beta polypeptide 2; glial cell adhesion molecule; Na, K-ATPase beta-2 polypeptide; snoRNA MBI-85; Sodium Potassium ATPase; sodium pump subunit beta-2; sodium-potassium ATPase subunit beta 2 (non-catalytic); sodium/potassium-dependent ATPase beta-2 subunit; Sodium/potassium-dependent ATPase subunit beta-2; sodium/potassium-transporting ATPase beta-2 chain; Sodium/potassium-transporting ATPase subunit beta-2

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Gene Aliases: AMOG; ATP1B2; Atpb-2; ATPB2; ATPB2S; RATATPB2S

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UniProt ID: (Human) P14415, (Mouse) P14231

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Entrez Gene ID: (Human) 482, (Rat) 24214, (Mouse) 11932

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Function(s)

ATPase activator activity sodium:potassium-exchanging ATPase activity protein binding ATPase binding

Process(es)

potassium ion transport cellular sodium ion homeostasis cell adhesion potassium ion import cellular potassium ion homeostasis positive regulation of ATPase activity sodium ion transmembrane transport sodium ion export from cell protein stabilization membrane repolarization positive regulation of potassium ion transmembrane transporter activity positive regulation of sodium ion export from cell positive regulation of potassium ion import transport establishment or maintenance of transmembrane electrochemical gradient ion transmembrane transport leukocyte migration cell communication by electrical coupling involved in cardiac conduction ATP hydrolysis coupled transmembrane transport regulation of cardiac conduction ion transport sodium ion transport

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ATP1B2 Polyclonal Antibody

ATP1B2 Antibody (22338-1-AP) in IHC (P)

Product Details

22338-1-AP

Western Blot (WB)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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