Abnova

ATP2B4 Monoclonal Antibody (2G8)

View all (7) PMCA4 ATPase antibodies

Promotion

View available promotion(s)

Promo code: {{promo.promoCode}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}

Datasheet
Protocols
Questions & Answers
Datasheet
Protocols
Questions & Answers

Product Details

H00000493-M07

Applications
Tested Dilution
Publications

Western Blot (WB)

1-5 µg/mL
-

ELISA (ELISA)

10 µg/mL
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Mouse / IgG1, kappa

Class

Monoclonal

Type

Antibody

Clone

2G8

Immunogen

ATP2B4 (NP_001675, 1 a.a. approximately 92 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
View immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.5 mg/mL

Purification

Protein A

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

Product Specific Information

Product may be used with Sandwich ELISA (Recombinant protein).

Immunogen sequence: MTNPSDRVLP ANSMAESREG DFGCTVMELR KLMELRSRDA LTQINVHYGG VQNLCSRLKT SPVEGLSGNP ADLEKRRQVF GHNVIPPKKP KT

Target Information

The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to a number of other ATPases including the SERCA ATPase and the sodium/K+ pump. There are four different genes encoding PMCA ATPase and studies have revealed 20 isoforms of the pump generated by alternate splicing of the primary gene products. mRNA distribution studies show that gene products 1 and 4 are transcribed in most tissues, however, products 2 and 3 are more tissue specific. Transcription of the splicing variants has also been found to be tissue specific. In the pancreas, where insulin secretion is calcium dependent, the beta cells only express the 4b isoform, however the alpha and gamma cells express both 4a and 4b isoforms. Studies have also shown that different splice variants have different affinities for calcium and calmodulin (Cat. # MA3-917 and MA3-918).

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

References (0)

Have you cited this product in a publication?
Let us know so we can reference it here.
Cite this product

Bioinformatics

Protein Aliases: ATPase, Ca++ transporting, plasma membrane 4; Matrix-remodeling-associated protein 1; Plasma membrane calcium ATPase isoform 4; Plasma membrane calcium pump isoform 4; Plasma membrane calcium-transporting ATPase 4; PMCA4; sarcolemmal calcium pump

View more View less

Gene Aliases: ATP2B2; ATP2B4; MXRA1; PMCA4; PMCA4b; PMCA4x

View more View less

UniProt ID: (Human) P23634

View more View less

Entrez Gene ID: (Human) 493

View more View less

Function(s)
calcium-transporting ATPase activity protein binding calmodulin binding ATP binding sodium channel regulator activity PDZ domain binding protein phosphatase 2B binding nitric-oxide synthase inhibitor activity metal ion binding nitric-oxide synthase binding scaffold protein binding
Process(es)
neural retina development regulation of transcription from RNA polymerase II promoter cellular calcium ion homeostasis spermatogenesis negative regulation of nitric oxide mediated signal transduction hippocampus development sperm motility positive regulation of peptidyl-serine phosphorylation ion transmembrane transport negative regulation of nitric oxide biosynthetic process negative regulation of nitric-oxide synthase activity response to hydrostatic pressure calcium ion transmembrane transport negative regulation of calcineurin-NFAT signaling cascade cellular response to epinephrine stimulus calcium ion transmembrane import into cytosol calcium ion import across plasma membrane negative regulation of the force of heart contraction negative regulation of arginine catabolic process negative regulation of adrenergic receptor signaling pathway involved in heart process calcium ion export negative regulation of peptidyl-cysteine S-nitrosylation regulation of sodium ion transmembrane transport regulation of cell cycle G1/S phase transition negative regulation of cardiac muscle hypertrophy in response to stress negative regulation of citrulline biosynthetic process regulation of cardiac conduction positive regulation of cAMP-dependent protein kinase activity
guarantee_icon

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

Learn more
help_icon

We're here to help

Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.

Contact tech support