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Invitrogen
ATP2C1 Polyclonal Antibody
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ATP2C1 Antibody (PA5-109430) in IHC (P)
Immunohistochemistry analysis of ATP2C1 in paraffin-embedded human stomach. Samples were incubated with ATP2C1 Polyclonal antibody (Product # PA5-109430) using a dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
Product Details
PA5-109430
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 400-660 of human ATP2C1 (NP_001186114.1).
Conjugate
Form
Liquid
Concentration
0.47 mg/mL
Purification
Affinity Chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2854841
Product Specific Information
Immunogen sequence: AVSRIVEAGC VCNDAVIRNN TLMGKPTEGA LIALAMKMGL DGLQQDYIRK AEYPFSSEQK WMAVKCVHRT QQDRPEICFM KGAYEQVIKY CTTYQSKGQT LTLTQQQRDV YQQEKARMGS AGLRVLALAS GPELGQLTFL GLVGIIDPPR TGVKEAVTTL IASGVSIKMI TGDSQETAVA IASRLGLYSK TSQSVSGEEI DAMDVQQLSQ IVPKVAVFYR ASPRHKMKII KSLQKNGSVV AMTGDGVNDA VALKAADIGV A
Target Information
ATP2C1, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin. Unlike the related protein ATP2C2, ATP2C1 is ubiquitously expressed and displays a lower maximal turnover rate for overall Ca2+-ATPase reaction and a higher apparent affinity for cytosolic Ca2+ activation of phosphorylation. Recent evidence suggests that ATP2C1 is a key regulator of insulin-like growth factor receptor (IGF1R) processing in tumor progression in basal breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATP-dependent Ca(2+) pump PMR1; ATPase 2C1; ATPase, Ca(2+)-sequestering; ATPase, Ca++ transporting, type 2C, member 1; ATPase, Ca++-sequestering; Ca(2+)/Mn(2+)-ATPase 2C1; calcium-transporting ATPase 2C1; Calcium-transporting ATPase type 2C member 1; HUSSY 28; HUSSY-28; rat; secretory pathway Ca(2+)-ATPase 1; Secretory pathway Ca(2+)-transporting ATPase type 1; secretory pathway Ca2+/Mn2+ ATPase 1; SPCA1
Gene Aliases: 1700121J11Rik; ATP2C1; ATP2C1A; AW061228; BCPM; D930003G21Rik; HHD; hSPCA1; HUSSY-28; KIAA1347; PMR1; PMR1L; SPCA; SPCA1
UniProt ID: (Human) P98194, (Mouse) Q80XR2
Entrez Gene ID: (Human) 27032, (Rat) 170699, (Mouse) 235574
calcium ion transport
manganese ion transport
cellular calcium ion homeostasis
signal transduction
metabolic process
epidermis development
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
cellular manganese ion homeostasis
actin cytoskeleton reorganization
Golgi calcium ion homeostasis
Golgi calcium ion transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
calcium ion import
calcium ion transmembrane transport
manganese ion transmembrane transport
ion transmembrane transport
transport
ion transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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