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Product Details
MA5-15592
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Non-human primate
Host/Isotype
Mouse
/ IgG1
Class
Monoclonal
Type
Antibody
Clone
4G12
Immunogen
Purified recombinant fragment of ATP2C1 expressed in E. Coli.
Conjugate
Form
Liquid
Concentration
Conc. Not Determined
Storage buffer
ascites
Contains
0.03% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_10982222
Product Specific Information
MA5-15592 targets ATP2C1 in indirect ELISA, IHC and WB applications and shows reactivity with Human and Non-human primate samples.
The MA5-15592 immunogen is purified recombinant fragment of ATP2C1 expressed in E. Coli.
MA5-15592 detects ATP2C1 which has a predicted molecular weight of approximately 100kDa.
Target Information
ATP2C1, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 1, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in this gene cause Hailey-Hailey disease, an autosomal dominant disorder characterized by persistent blisters and erosions of the skin. Unlike the related protein ATP2C2, ATP2C1 is ubiquitously expressed and displays a lower maximal turnover rate for overall Ca2+-ATPase reaction and a higher apparent affinity for cytosolic Ca2+ activation of phosphorylation. Recent evidence suggests that ATP2C1 is a key regulator of insulin-like growth factor receptor (IGF1R) processing in tumor progression in basal breast cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ATP-dependent Ca(2+) pump PMR1; ATPase 2C1; ATPase, Ca(2+)-sequestering; ATPase, Ca++ transporting, type 2C, member 1; Ca(2+)/Mn(2+)-ATPase 2C1; Calcium-transporting ATPase type 2C member 1; HUSSY 28; HUSSY-28; rat; Secretory pathway Ca(2+)-transporting ATPase type 1; secretory pathway Ca2+/Mn2+ ATPase 1; SPCA1
Gene Aliases: ATP2C1; ATP2C1A; BCPM; HHD; hSPCA1; HUSSY-28; KIAA1347; PMR1; PMR1L; SPCA1
UniProt ID: (Human) P98194
Entrez Gene ID: (Human) 27032
calcium ion transport
cellular calcium ion homeostasis
signal transduction
epidermis development
calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules
actin cytoskeleton reorganization
Golgi calcium ion homeostasis
Golgi calcium ion transport
ion transmembrane transport
positive regulation of I-kappaB kinase/NF-kappaB signaling
calcium ion transmembrane transport
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