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Proteintech
ATP6AP1 Polyclonal Antibody
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Product Details
15305-1-AP
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
ATP6AP1 Fusion Protein Ag7859 (45-422 aa encoded by BC000724)
Conjugate
Form
Liquid
Concentration
0.13 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.3, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice (domestic); Dry ice (international)
Product Specific Information
Immunogen sequence: VPLVLWSSD RDLWAPAADT HEGHITSDLQ LSTYLDPALE LGPRNVLLFL QDKLSIEDFT AYGGVFGNKQ DSAFSNLENA LDLAPSSLVL PAVDWYAVST LTTYLQEKLG ASPLHVDLAT LRELKLNASL PALLLIRLPY TASSGLMAPR EVLTGNDEVI GQVLSTLKSE DVPYTAALTA VRPSRVARDV AVVAGGLGRQ LLQKQPVSPV IHPPVSYNDT APRILFWAQN FSVAYKDQWE DLTPLTFGVQ ELNLTGSFWN DSFARLSLTY ERLFGTTVTF KFILANRLYP VSARHWFTME RLEVHSNGSV AYFNASQVTG PSIYSFHCEY VSSLSKKGSL LVARTQPSPW QMMLQDFQIQ AFNVMGEQFS YASDCASFF (45-422 aa encoded by BC000724)
Target Information
Vacuolar-type H+-ATPase (V-ATPase) is a multisubunit enzyme responsible for acidification of eukaryotic intracellular organelles. V-ATPases pump protons against an electrochemical gradient, thereby synthesizing ATP. A peripheral V1 domain, which is responsible for ATP hydrolysis, and an integral V0 domain, which is responsible for proton translocation, compose the V-ATPase. Nine subunits (A-H) make up the V1 domain and five subunits (a, d, c, c' and c"") make up the V0 domain. ATP6AP1 (ATPase, H+ transporting, lysosomal accessory protein 1), also known as 16A, CF2, Ac45, XAP3, ATP6S1, VATPS1 (vacuolar ATP synthase S1 accessory protein) or ATP6IP1, is a type I transmembrane, V-ATPase accessory protein that is predominantly expressed in endocrine and neuronal cells. ATP6AP1 is responsible for targeting the V-ATPase enzyme to specialized complex vacuolar systems. Via its cytoplasmic tail, ATP6AP1 interacts with subunits of the V0 domain. The disruption of this interaction in osteoclasts results in impaired bone resorption, suggesting an important role for ATP6AP1 in proper osteoclastic bone resorption.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1; ATPase, H+ transporting, lysosomal accessory protein 1; ATPase, H+ transporting, lysosomal interacting protein 1; C7-1 protein; H-ATPase subunit; MGC129781; Protein C7-1; Protein XAP-3; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; V-ATPase subunit Ac45; V-ATPase subunit S1; V-type proton ATPase subunit S1; vacuolar H+ ATPase accessory subunit 1; Vacuolar proton pump subunit S1
Gene Aliases: 16A; AC45; AI316502; ATP6AP1; ATP6IP1; ATP6S1; AW108110; C7-1; CF2; mFLJ00383; VATPS1; XAP-3; XAP3
UniProt ID: (Human) Q15904, (Mouse) Q9R1Q9, (Rat) O54715
Entrez Gene ID: (Human) 537, (Mouse) 54411, (Rat) 83615
insulin receptor signaling pathway
ATP hydrolysis coupled proton transport
proton transport
transferrin transport
ion transmembrane transport
positive regulation of osteoblast differentiation
positive regulation of bone resorption
pH reduction
positive regulation of exocytosis
establishment of organelle localization
positive regulation of ERK1 and ERK2 cascade
positive regulation of osteoclast development
transport
ion transport
cell death
proton-transporting V-type ATPase complex assembly
aging
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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