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Invitrogen
ATP6V0A1 Polyclonal Antibody
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Product Details
PA5-54570
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Published species
Human
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Recombinant protein corresponding to Human ATP6V0A1. Recombinant protein control fragment (Product #RP-93230).
Conjugate
Form
Liquid
Concentration
0.2 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
PBS, pH 7.2, with 40% glycerol
Contains
0.02% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
AB_2638371
Product Specific Information
Immunogen sequence: VQFRDLNPDV NVFQRKFVNE VRRCEEMDRK LRFVEKEIRK ANIPIMDTGE NPEVPFPRDM IDLEANFEKI ENELKEINTN QEALKRNFLE LTELK
Highest antigen sequence identity to the following orthologs: Mouse - 100%, Rat - 100%.
Target Information
ATP6V0A1 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes one of three A subunit proteins and the encoded protein is associated with clathrin-coated vesicles.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: adenosine triphosphatase; ATPase, H+ transporting, lysosomal non-catalytic accessory protein 1 (110/116kD); ATPase, H+ transporting, lysosomal V0 subunit a1; Clathrin-coated vesicle/synaptic vesicle proton pump 116 kDa subunit; H(+)-transporting two-sector ATPase, 116 kDa accessory protein A1; V-A; V-ATPase 116 kDa; V-ATPase 116 kDa subunit a 1; V-type proton ATPase 116 kDa subunit a; V-type proton ATPase 116 kDa subunit a 1; Vacuolar adenosine triphosphatase subunit Ac116; Vacuolar proton pump subunit 1; vacuolar proton translocating ATPase 116 kDa subunit A; Vacuolar proton translocating ATPase 116 kDa subunit a isoform 1; vacuolar-type H(+)-ATPase 115 kDa subunit
Gene Aliases: a1; ATP6N1; ATP6N1A; ATP6V0A1; Stv1; Vph1; VPP1
UniProt ID: (Human) Q93050
Entrez Gene ID: (Human) 535
vacuolar acidification
insulin receptor signaling pathway
ATP synthesis coupled proton transport
ATP hydrolysis coupled proton transport
regulation of macroautophagy
transferrin transport
ion transmembrane transport
vacuolar proton-transporting V-type ATPase complex assembly
phagosome acidification
toxin transport
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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