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FIGURE: 1 / 1
Sequence of this protein is as follows: MSEFWLISAP GDKENLQALE RMNTVTSKSN LSYNTKFAIP DFKVGTLDSL VGLSDELGKL DTFAESLIRR MAQSVVEVME DSKGKVQEHL LANGVDLTSF VTHFEWDMAK YPVKQPLVSV VDTIAKQLAQ IEMDLKSRTA AYDTLKTNLE NLEKKSMGNL FTRTLSDIVS KEDFVLDSEY LVTLLVIVPK PNYSQWQKTY ESLSDMVVPR STKLITEDKE GGLFTVTLFR KVIEDFKTKA KENKFTVREF YYDEKEIERE REEMARLLSD KKQQYGPLLR WLKVNFSEAF IAWIHIKALR VFVESVLRYG LPVNFQAVLL QPHKKSSTKR LREVLNSVFR HLDEVAATSI LDASVEIPGL QLNNQDYFPY VYFHIDLSLL D
ATP6V1C2 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A, three B, and two G subunits, as well as a C, D, E, F, and H subunit. The V1 domain contains the ATP catalytic site. This gene encodes alternate transcriptional splice variants, encoding different V1 domain C subunit isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ATPase, H+ transporting, lysosomal 42kDa, V1 subunit C2; V-ATPase C2 subunit; V-ATPase subunit C 2; V-type proton ATPase subunit C 2; Vacuolar proton pump subunit C 2
Gene Aliases: ATP6C2; ATP6V1C2; VMA5
UniProt ID: (Human) Q8NEY4
Entrez Gene ID: (Human) 245973
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