Proteintech

ATR Polyclonal Antibody

ATR Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ATR Antibody (19787-1-AP) in IHC (P)

Immunohistochemical analysis of paraffin-embedded mouse testis tissue slide using (Product # 19787-1-AP) (ATR antibody) at dilution of 1:200 (under 10x lens). Heat mediated antigen retrieval with Tris-EDTA buffer (pH 9.0).

ATR Antibody in Immunoprecipitation (IP)

Product Image Gallery

Product Details

19787-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:300-1:1,000

View 21 publications 21 publications

Immunohistochemistry (IHC)

View 3 publications 3 publications

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:500

Immunocytochemistry (ICC/IF)

View 1 publication 1 publication

Immunoprecipitation (IP)

1:500

Product Specifications

Species Reactivity

Human, Mouse

Published species

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Peptide

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.28 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

The antibody can recognize all the isoform of ATR.

Target Information

The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

PGC1α Degradation Suppresses Mitochondrial Biogenesis to Confer Radiation Resistance in Glioma.

Cancer research

Zhao M,Li Y,Lu C,Ding F,Xu M,Ge X,Li M,Wang Z,Yin J,Zhang J,Wang X,Ge Z,Xiao H,Xiao Y,Liu H,Liu W,Cao Y,Wang Q,You Y,Wang X,Yang K,Shi Z,Qian X

Tue Apr 04 00:00:00 UTC 2023

Combined Inactivation of CTPS1 and ATR Is Synthetically Lethal to MYC-Overexpressing Cancer Cells.

Cancer research

Sun Z,Zhang Z,Wang QQ,Liu JL

Tue Mar 15 00:00:00 UTC 2022

Analysis by transcriptomics and metabolomics for the proliferation inhibition and dysfunction through redox imbalance-mediated DNA damage response and ferroptosis in male reproduction of mice and TM4 Sertoli cells exposed to PM_2.5.

Ecotoxicology and environmental safety

Shi F,Zhang Z,Cui H,Wang J,Wang Y,Tang Y,Yang W,Zou P,Ling X,Han F,Liu J,Chen Q,Liu C,Cao J,Ao L

Wed Jun 15 00:00:00 UTC 2022

Identification of core genes in prefrontal cortex and hippocampus of Alzheimer's disease based on mRNA-miRNA network.

Journal of cellular and molecular medicine

Huang ZH,Wang H,Wang DM,Zhao XY,Liu WW,Zhong X,He DM,Mu BR,Lu MH

Thu Dec 01 00:00:00 UTC 2022

STEMIN and YAP5SA synthetic modified mRNAs regenerate and repair infarcted mouse hearts.

The journal of cardiovascular aging

Xiao S,Liang R,Lucero E,McConnell BK,Chen Z,Chang J,Navran S,Schwartz RJ,Iyer D

Fri Jul 01 00:00:00 UTC 2022

Yttrium chloride-induced cytotoxicity and DNA damage response via ROS generation and inhibition of Nrf2/PPARγ pathways in H9c2 cardiomyocytes.

Archives of toxicology

Xiong L,Huang J,Wang S,Yuan Q,Yang D,Zheng Z,Wu Y,Wu C,Gao Y,Zou L,Hu G

Tue Mar 01 00:00:00 UTC 2022

The Interplay of Four Main Pathways Recomposes Immune Landscape in Primary and Metastatic Gastroenteropancreatic Neuroendocrine Tumors.

Frontiers in oncology

Lou X,Gao H,Xu X,Ye Z,Zhang W,Wang F,Chen J,Zhang Y,Chen X,Qin Y,Yu X,Ji S

Tue Mar 28 00:00:00 UTC 2023

LncRNA linc00312 suppresses radiotherapy resistance by targeting DNA-PKcs and impairing DNA damage repair in nasopharyngeal carcinoma.

Cell death & disease

Guo Z,Wang YH,Xu H,Yuan CS,Zhou HH,Huang WH,Wang H,Zhang W

Mon Jan 04 00:00:00 UTC 2021

Ddb1 Is Essential for the Expansion of CD4⁺ Helper T Cells by Regulating Cell Cycle Progression and Cell Death.

Frontiers in immunology

Yang L,Chen W,Li L,Xiao Y,Fan S,Zhang Q,Xia T,Li M,Hong Y,Zhao T,Li Q,Liu WH,Xiao N

Mon Dec 20 00:00:00 UTC 2021

Antifungal agent Terbinafine restrains tumor growth in preclinical models of hepatocellular carcinoma via AMPK-mTOR axis.

Oncogene

Zhang EB,Zhang X,Wang K,Zhang F,Chen TW,Ma N,Ni QZ,Wang YK,Zheng QW,Cao HJ,Xia J,Zhu B,Xu S,Ding X,Wang X,Li Z,Cheng S,Xie D,Li JJ

Sun Aug 01 00:00:00 UTC 2021

MET inhibition enhances PARP inhibitor efficacy in castration-resistant prostate cancer by suppressing the ATM/ATR and PI3K/AKT pathways.

Journal of cellular and molecular medicine

Zhou S,Dai Z,Wang L,Gao X,Yang L,Wang Z,Wang Q,Liu Z

Wed Dec 01 00:00:00 UTC 2021

MET inhibition enhances PARP inhibitor efficacy in castration-resistant prostate cancer by suppressing the ATM/ATR and PI3K/AKT pathways.

Journal of cellular and molecular medicine

Zhou S,Dai Z,Wang L,Gao X,Yang L,Wang Z,Wang Q,Liu Z

Wed Dec 01 00:00:00 UTC 2021

Asparaginyl endopeptidase (AEP) regulates myocardial apoptosis in response to radiation exposure via alterations in NRF2 activation.

American journal of cancer research

Cao L,Xu C,Yi P,Li H,Lin Y,Cai G,Wang S,Ou D,Li M,Chen J

Fri May 07 00:00:00 UTC 2021

Potent USP10/13 antagonist spautin-1 suppresses melanoma growth via ROS-mediated DNA damage and exhibits synergy with cisplatin.

Journal of cellular and molecular medicine

Guo J,Zhang J,Liang L,Liu N,Qi M,Zhao S,Su J,Liu J,Peng C,Chen X,Liu H

Wed Apr 01 00:00:00 UTC 2020

Novel SAHA‑bendamustine hybrid NL‑101 in combination with daunorubicin synergistically suppresses acute myeloid leukemia.

Oncology reports

Jin J,Li X,Guo W,Li F,Huang J,Huang X,Pan J,Huang S,Ye W,Ling Q,Jin J

Wed Jul 01 00:00:00 UTC 2020

UBE2T-regulated H2AX monoubiquitination induces hepatocellular carcinoma radioresistance by facilitating CHK1 activation.

Journal of experimental & clinical cancer research : CR

Sun J,Zhu Z,Li W,Shen M,Cao C,Sun Q,Guo Z,Liu L,Wu D

Wed Oct 21 00:00:00 UTC 2020

Graphene Oxide Causes Disordered Zonation Due to Differential Intralobular Localization in the Liver.

ACS nano

Wu Y,Feng W,Liu R,Xia T,Liu S

Tue Jan 28 00:00:00 UTC 2020

A novel alkylating deacetylase inhibitor molecule EDO-S101 in combination with cytarabine synergistically enhances apoptosis of acute myeloid leukemia cells.

Medical oncology (Northwood, London, England)

Jin J,Mao S,Li F,Li X,Huang X,Yu M,Guo W,Jin J

Thu Aug 01 00:00:00 UTC 2019

DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.

Cell research

Zheng P,Chen Q,Tian X,Qian N,Chai P,Liu B,Hu J,Blackstone C,Zhu D,Teng J,Chen J

Wed Aug 01 00:00:00 UTC 2018

DNA damage triggers tubular endoplasmic reticulum extension to promote apoptosis by facilitating ER-mitochondria signaling.

Cell research

Zheng P,Chen Q,Tian X,Qian N,Chai P,Liu B,Hu J,Blackstone C,Zhu D,Teng J,Chen J

Wed Aug 01 00:00:00 UTC 2018

ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage.

Nature communications

Liu M,Zeng T,Zhang X,Liu C,Wu Z,Yao L,Xie C,Xia H,Lin Q,Xie L,Zhou D,Deng X,Chan HL,Zhao TJ,Wang HR

Mon Oct 08 00:00:00 UTC 2018

ATR/Chk1 signaling induces autophagy through sumoylated RhoB-mediated lysosomal translocation of TSC2 after DNA damage.

Nature communications

Liu M,Zeng T,Zhang X,Liu C,Wu Z,Yao L,Xie C,Xia H,Lin Q,Xie L,Zhou D,Deng X,Chan HL,Zhao TJ,Wang HR

Mon Oct 08 00:00:00 UTC 2018

Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.

Journal of agricultural and food chemistry

Wei J,Zhang G,Zhang X,Xu D,Gao J,Fan J,Zhou Z

Wed Jul 26 00:00:00 UTC 2017

Anthocyanins from Black Chokeberry (Aroniamelanocarpa Elliot) Delayed Aging-Related Degenerative Changes of Brain.

Journal of agricultural and food chemistry

Wei J,Zhang G,Zhang X,Xu D,Gao J,Fan J,Zhou Z

Wed Jul 26 00:00:00 UTC 2017

Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver.

Plant foods for human nutrition (Dordrecht, Netherlands)

Wei J,Zhang G,Zhang X,Xu D,Gao J,Fan J

Fri Dec 01 00:00:00 UTC 2017

Anthocyanins Delay Ageing-Related Degenerative Changes in the Liver.

Plant foods for human nutrition (Dordrecht, Netherlands)

Wei J,Zhang G,Zhang X,Xu D,Gao J,Fan J

Fri Dec 01 00:00:00 UTC 2017

Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.

Toxicology and applied pharmacology

Dong H,Shi Q,Song X,Fu J,Hu L,Xu D,Su C,Xia X,Song E,Song Y

Wed Jul 01 00:00:00 UTC 2015

Polychlorinated biphenyl quinone induces oxidative DNA damage and repair responses: The activations of NHEJ, BER and NER via ATM-p53 signaling axis.

Toxicology and applied pharmacology

Dong H,Shi Q,Song X,Fu J,Hu L,Xu D,Su C,Xia X,Song E,Song Y

Wed Jul 01 00:00:00 UTC 2015

Methylmalonic aciduria cblB type: characterization of two novel mutations and mitochondrial dysfunction studies.

Clinical genetics

Brasil S,Richard E,Jorge-Finnigan A,Leal F,Merinero B,Banerjee R,Desviat LR,Ugarte M,Pérez B

Mon Jun 01 00:00:00 UTC 2015

Methylmalonic aciduria cblB type: characterization of two novel mutations and mitochondrial dysfunction studies.

Clinical genetics

Brasil S,Richard E,Jorge-Finnigan A,Leal F,Merinero B,Banerjee R,Desviat LR,Ugarte M,Pérez B

Mon Jun 01 00:00:00 UTC 2015

Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells.

Chemical research in toxicology

Song X,Li L,Shi Q,Lehmler HJ,Fu J,Su C,Xia X,Song E,Song Y

Mon Nov 16 00:00:00 UTC 2015

Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells.

Chemical research in toxicology

Song X,Li L,Shi Q,Lehmler HJ,Fu J,Su C,Xia X,Song E,Song Y

Mon Nov 16 00:00:00 UTC 2015

Bioinformatics

Protein Aliases: 2310008J16Rik; 2810405N18Rik; Ataxia telangiectasia and Rad3-related protein; EC 2.7.11.1; FRAP-related protein 1; FRAP-related protein-1; kinase ATR; MEC1, mitosis entry checkpoint 1, homolog; protein kinase ATR; Serine/threonine-protein kinase ATR; TEM8

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Gene Aliases: ATR; FCTCS; FRP1; MEC1; SCKL; SCKL1

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UniProt ID: (Human) Q13535

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Entrez Gene ID: (Human) 545, (Mouse) 245000

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Function(s)

DNA binding protein kinase activity protein serine/threonine kinase activity protein binding ATP binding MutLalpha complex binding MutSalpha complex binding nucleotide binding kinase activity transferase activity transferase activity, transferring phosphorus-containing groups phosphotransferase activity, alcohol group as acceptor protein dimerization activity

Process(es)

DNA damage checkpoint double-strand break repair via homologous recombination DNA repair protein phosphorylation cellular response to DNA damage stimulus negative regulation of DNA replication phosphorylation peptidyl-serine phosphorylation cellular response to UV regulation of protein binding positive regulation of DNA damage response, signal transduction by p53 class mediator protein autophosphorylation cellular response to gamma radiation replicative senescence DNA replication cell cycle multicellular organism development positive regulation of telomere maintenance via telomerase interstrand cross-link repair response to drug protein localization to chromosome, telomeric region establishment of RNA localization to telomere establishment of macromolecular complex localization to telomere regulation of cellular response to heat regulation of signal transduction by p53 class mediator positive regulation of telomerase catalytic core complex assembly

Performance Guarantee

If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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ATR Polyclonal Antibody

ATR Antibody (19787-1-AP) in IHC (P)

Product Details

19787-1-AP

Western Blot (WB)

Immunohistochemistry (IHC)

Immunohistochemistry (Paraffin) (IHC (P))

Immunocytochemistry (ICC/IF)

Immunoprecipitation (IP)

Species Reactivity

Published species

Host/Isotype

Class

Type

Immunogen

Conjugate

Form

Concentration

Purification

Storage buffer

Contains

Storage conditions

Shipping conditions

Product Specific Information

Target Information

Bioinformatics

Performance Guarantee

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