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Bethyl Laboratories
ATX2/SCA2 Polyclonal Antibody
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ATX2/SCA2 Antibody (A301-118A) in WB
Detection of human and mouse ATX2/SCA2 by western blot. Samples: Whole cell lysate (50 µg) from HeLa, HEK293T, Jurkat, and mouse TCMK-1 cells. Antibodies: Affinity purified rabbit anti-ATX2/SCA2 antibody (Product # A301-118A) (lot A301-118A-2) used for WB at 0.4 µg/mL. Detection: Chemiluminescence with an exposure time of 3 minutes.
Product Details
A301-118A
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
Region between residue 1262 and 1312 of human ataxin 2 (spinocerebellar ataxia 2).
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Antigen affinity chromatography
Storage buffer
tris citrate/phosphate, pH 7-8
Contains
0.09% sodium azide
Storage conditions
4°C
Shipping conditions
Ambient (domestic); Wet ice (international)
Product Specific Information
The recommended shelf life for this product is 1 year from date of receipt.
Target Information
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA2 is caused by expansion of a CAG repeat in the coding region of this gene. Longer expansions result in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified but their full length sequence has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Ataxin-2; FLJ46772; spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant, ataxin 2); spinocerebellar ataxia 2 homolog; Spinocerebellar ataxia type 2 protein; Spinocerebellar ataxia type 2 protein homolog; Trinucleotide repeat-containing gene 13 protein
Gene Aliases: 9630045M23Rik; ASL13; ATX2; ATXN2; AW544490; SCA2; TNRC13
UniProt ID: (Human) Q99700, (Mouse) O70305
Entrez Gene ID: (Human) 6311, (Mouse) 20239
negative regulation of receptor internalization
regulation of translation
regulation of cytoplasmic mRNA processing body assembly
RNA metabolic process
cytoplasmic mRNA processing body assembly
stress granule assembly
RNA transport
cerebellar Purkinje cell differentiation
negative regulation of multicellular organism growth
neuron projection morphogenesis
homeostasis of number of cells
neuromuscular process
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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