Proteintech

ATX3/ATXN3 Polyclonal Antibody

ATX3/ATXN3 Antibody in Immunohistochemistry (Paraffin) (IHC (P))

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ATX3/ATXN3 Antibody (13505-1-AP) in IHC (P)

Immunohistochemistry of paraffin-embedded human pancreas cancer using 13505-1-AP (ATX3,ATXN3 antibody) at dilution of 1:100 (under 40x lens).

ATX3/ATXN3 Antibody in Western Blot (WB)

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Product Details

13505-1-AP

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

View 15 publications 15 publications

Immunohistochemistry (IHC)

View 1 publication 1 publication

Immunohistochemistry (Paraffin) (IHC (P))

1:20-1:200

Immunocytochemistry (ICC/IF)

View 2 publications 2 publications

Immunoprecipitation (IP)

Assay-dependent

View 1 publication 1 publication

Product Specifications

Species Reactivity

Human, Mouse, Rat

Published species

Human, Mouse, Plant

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

ATX3,ATXN3 Fusion Protein Ag4341 (1-370 aa encoded by BC033711)

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

0.37 mg/mL

Purification

Antigen affinity chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.02% sodium azide

Storage conditions

-20°C

Shipping conditions

Wet ice (domestic); Dry ice (international)

Product Specific Information

Immunogen sequence: MESIFHEKQ EGSLCAQHCL NNLLQGEYFS PVELSSIAHQ LDEEERMRMA EGGVTSEDYR TFLQQPSGNM DDSGFFSIQV ISNALKVWGL ELILFNSPEY QRLRIDPINE RSFICNYKEH WFTVRKLGKQ WFNLNSLLTG PELISDTYLA LFLAQLQQEG YSIFVVKGDL PDCEADQLLQ MIRVQQMHRP KLIGEELAQL KEQRVHKTDL ERVLEANDGS GMLDEDEEDL QRALALSRQE IDMEDEEADL RRAIQLSMQG SSRNISQDMT QTSGTNLTSE ELRKRREAYF EKQQQKQQQQ QQQQQQQQQQ QQQQQGDLSG QSSHPCERPA TSSGALGSDL GDAMSEEDML QAAVTMSLET VRNDLKTEGK K (1-370 aa encoded by BC033711)

Target Information

Machado-Joseph disease is an autosomal dominant neurologic disorder, and is now known to be the same as previously described spinocerebellar ataxia-3. MJD protein (Ataxin-3) contains (CAG)n repeats in the coding region, and the expansion of these repeats from the normal 13-36 to 68-79 is the cause of Machado-Joseph disease. There is a negative correlation between the age of onset and CAG repeat numbers. This protein interacts with key regulators (CBP, p300 and PCAF) of transcription and represses transcription, and also acts as a histone-binding protein that regulates transcription. MJD is a deubiquitinating enzyme.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Human DNA polymerase η promotes RNA-templated error-free repair of DNA double-strand breaks.

The Journal of biological chemistry

Chakraborty A,Tapryal N,Islam A,Sarker AH,Manohar K,Mitra J,Hegde ML,Hazra T

Wed Mar 01 00:00:00 UTC 2023

CircHIPK3 negatively regulates autophagy by blocking VCP binding to the Beclin 1 complex in bladder cancer.

Discover oncology

Wang C,Liu T,Wang J,Cheng C,Zhang Z,Zhang J,Huang H,Li Y

Sat Jun 03 00:00:00 UTC 2023

The Mechano-Ubiquitinome of Articular Cartilage: Differential Ubiquitination and Activation of a Group of ER-Associated DUBs and ER Stress Regulators.

Molecular & cellular proteomics : MCP

Kaokhum N,Pinto-Fernández A,Wilkinson M,Kessler BM,Ismail HM

Thu Dec 01 00:00:00 UTC 2022

DNAzyme Cleavage of CAG Repeat RNA in Polyglutamine Diseases.

Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics

Zhang N,Bewick B,Schultz J,Tiwari A,Krencik R,Zhang A,Adachi K,Xia G,Yun K,Sarkar P,Ashizawa T

Thu Jul 01 00:00:00 UTC 2021

Involvement of miR-619-5p in resistance to cisplatin by regulating ATXN3 in oral squamous cell carcinoma.

International journal of biological sciences

Song A,Wu Y,Chu W,Yang X,Zhu Z,Yan E,Zhang W,Zhou J,Ding X,Liu J,Zhu H,Ye J,Wu Y,Zheng Y,Song X

Fri Jan 14 00:00:00 UTC 2022

Involvement of miR-619-5p in resistance to cisplatin by regulating ATXN3 in oral squamous cell carcinoma.

International journal of biological sciences

Song A,Wu Y,Chu W,Yang X,Zhu Z,Yan E,Zhang W,Zhou J,Ding X,Liu J,Zhu H,Ye J,Wu Y,Zheng Y,Song X

Fri Jan 14 00:00:00 UTC 2022

USP15 participates in DBP-induced testicular oxidative stress injury through regulating the Keap1/Nrf2 signaling pathway.

The Science of the total environment

Zhang L,Gao X,Qin Z,Shi X,Xu K,Wang S,Tang M,Wang W,Gao S,Zuo L,Zhang L,Zhang W

Fri Aug 20 00:00:00 UTC 2021

TSPAN8 promotes cancer cell stemness via activation of sonic Hedgehog signaling.

Nature communications

Zhu R,Gires O,Zhu L,Liu J,Li J,Yang H,Ju G,Huang J,Ge W,Chen Y,Lu Z,Wang H

Fri Jun 28 00:00:00 UTC 2019

CRISPR/Cas9-Targeted Deletion of Polyglutamine in Spinocerebellar Ataxia Type 3-Derived Induced Pluripotent Stem Cells.

Stem cells and development

Ouyang S,Xie Y,Xiong Z,Yang Y,Xian Y,Ou Z,Song B,Chen Y,Xie Y,Li H,Sun X

Fri Jun 01 00:00:00 UTC 2018

CRISPR/Cas9-Targeted Deletion of Polyglutamine in Spinocerebellar Ataxia Type 3-Derived Induced Pluripotent Stem Cells.

Stem cells and development

Ouyang S,Xie Y,Xiong Z,Yang Y,Xian Y,Ou Z,Song B,Chen Y,Xie Y,Li H,Sun X

Fri Jun 01 00:00:00 UTC 2018

ATXN3 Positively Regulates Type I IFN Antiviral Response by Deubiquitinating and Stabilizing HDAC3.

Journal of immunology (Baltimore, Md. : 1950)

Feng Q,Miao Y,Ge J,Yuan Y,Zuo Y,Qian L,Liu J,Cheng Q,Guo T,Zhang L,Yu Z,Zheng H

Sun Jul 15 00:00:00 UTC 2018

An Interaction Landscape of Ubiquitin Signaling.

Molecular cell

Zhang X,Smits AH,van Tilburg GB,Jansen PW,Makowski MM,Ovaa H,Vermeulen M

Thu Mar 02 00:00:00 UTC 2017

An Interaction Landscape of Ubiquitin Signaling.

Molecular cell

Zhang X,Smits AH,van Tilburg GB,Jansen PW,Makowski MM,Ovaa H,Vermeulen M

Thu Mar 02 00:00:00 UTC 2017

Rescue of ATXN3 neuronal toxicity in Caenorhabditiselegans by chemical modification of endoplasmic reticulum stress.

Disease models & mechanisms

Fardghassemi Y,Tauffenberger A,Gosselin S,Parker JA

Tue Dec 19 00:00:00 UTC 2017

Rescue of ATXN3 neuronal toxicity in Caenorhabditiselegans by chemical modification of endoplasmic reticulum stress.

Disease models & mechanisms

Fardghassemi Y,Tauffenberger A,Gosselin S,Parker JA

Tue Dec 19 00:00:00 UTC 2017

Rescue of ATXN3 neuronal toxicity in Caenorhabditiselegans by chemical modification of endoplasmic reticulum stress.

Disease models & mechanisms

Fardghassemi Y,Tauffenberger A,Gosselin S,Parker JA

Tue Dec 19 00:00:00 UTC 2017

Rescue of ATXN3 neuronal toxicity in Caenorhabditiselegans by chemical modification of endoplasmic reticulum stress.

Disease models & mechanisms

Fardghassemi Y,Tauffenberger A,Gosselin S,Parker JA

Tue Dec 19 00:00:00 UTC 2017

A new humanized ataxin-3 knock-in mouse model combines the genetic features, pathogenesis of neurons and glia and late disease onset of SCA3/MJD.

Neurobiology of disease

Switonski PM,Szlachcic WJ,Krzyzosiak WJ,Figiel M

Thu Jan 01 00:00:00 UTC 2015

A new humanized ataxin-3 knock-in mouse model combines the genetic features, pathogenesis of neurons and glia and late disease onset of SCA3/MJD.

Neurobiology of disease

Switonski PM,Szlachcic WJ,Krzyzosiak WJ,Figiel M

Thu Jan 01 00:00:00 UTC 2015

The role of the mammalian DNA end-processing enzyme polynucleotide kinase 3'-phosphatase in spinocerebellar ataxia type 3 pathogenesis.

PLoS genetics